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Showing 1 to 2 of 2 for “"cancer disease modeling"”.
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Targeting nucleic acids for pancreatic cancer: disease modeling and therapy
Pancreatic cancer is responsible for nearly 40,000 deaths in the U.S. annually, with a dismal 5-year survival rate below 7%. The poor therapeutic outcomes reflect a paucity of new approaches targeting the genomic underpinnings of pancreatic ductal adenocarcinomas (PDAC, the vast majority of …
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Modeling Cancer Using Li-Fraumeni Syndrome Patient-Derived Induced Pluripotent Stem Cells
… syndrome (LFS) is an autosomal dominant disease caused by germline mutations in the gene <em>TP53</em>, which predispose individuals to a wide range of malignancies, including osteosarcoma and breast cancer. In the previous study, our group developed a novel disease model platform by …