Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 41 for “"cancer cell survival"”.
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Investigating Novel Targets to Inhibit Cancer Cell Survival
Cancer remains the second leading cause of death in the United States and the world, despite years of research and the development of different treatments. One reason for this is cancer cells are able to survive through adaptation to their environment and aberrantly activated growth signaling. As …
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Genetic Determinants of Cancer Cell Survival in Tumor Microenvironment Stresses
<p>In order to propagate a solid tumor, cancer cells must adapt to and survive under various tumor microenvironment (TME) stresses, such as hypoxia or lactic acidosis. Additionally, cancer cells exposed to these stresses are more resistant to therapies, more likely to metastasize and often are …
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Part I: Steroid Receptor CO-Activator 3 (SRC-3) Expression in Lung Cancer and its Role in Regulating Cancer Cell Survival and Proliferation; Part II: Development of Phosphospecific Peptoid Ligand
… CO-ACTIVATOR 3 (SRC-3) EXPRESSION IN LUNG CANCER AND ITS ROLE IN REGULATING CANCER CELL SURVIVAL AND PROLIFERATION Steroid receptor coactivator-3 (SRC-3) is a histone acetyltransferase and nuclear hormone receptor (NHR) coactivator, located on 20q12, which is amplified in several epithelial …
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Validating the WD Repeat Protein CDC40 as a Potential Therapeutic Target for Lung Cancer
Lung cancer is the second most diagnosed and most lethal cancer globally. Presently, there is a need for novel targets for the development of improved therapeutics. Data mining of whole genome genetic dependency screens suggested that the pre-mRNA splicing factor Cell Division Cycle 40 (CDC40) is …
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The anticancer effects of the different analogs of cysteine deleted tachyplesin on A549 lung cancer cells
… little has been said about its possible anticancer effects and which analogs serve as the best inhibitors of the growing cancer cells. This research focused on CDT and four of its analogs: All D-CDT, Reverse DCDT, Reverse CDT, and Serine-Control CDT. MTT assays against the A549 adenocarcinoma …
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DESIGN AND DEVELOPMENT OF RNA-BASED DRUGS USING MOLECULAR DYNAMICS SIMULATIONS AND ARTIFICIAL INTELLIGENCE METHODS
… precise targeting for genetic disorders, cancer, and infectious diseases. Several RNA-based modalities have been developed, including messenger RNAs (mRNAs), small interfering RNAs (siRNAs), microRNAs (miRNAs), antisense oligonucleotides (ASOs), circular RNAs (circRNAs), and aptamers. …
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OPTIMISATION AND THERAPEUTIC-TARGET-DISCOVERY ORIENTED ANALYSIS OF CRISPR-CAS9 SCREENS
… of CRISPR-Cas9 technology has revolutionized cancer research by enabling targeted genome modifications in tumour cells, offering insights into cancer biology and potential treatment targets. My PhD research focuses on developing tailored tools and pipelines to enhance the analysis of …
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Dual Assembly Nanoparticles Achieve Sustained Silencing of Znf304: A Novel Transcription Factor For Β1 Integrin
<p>Ovarian cancer (OC) is a highly metastatic disease, but no effective strategies to this process currently are known. Here, an integrated computational analysis of The Cancer Genome Atlas ovarian cancer dataset coupled with experimental validation identified a novel zinc finger transcriptional …
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PHYTOCHEMICAL AND SYNTHETIC INVESTIGATIONAL COMPOUNDS AS MODULATORS OF CYTOMETABOLIC AND CYTOSKELETAL DYNAMICS FOR PRE-CLINICAL TARGETING OF PROSTATE CANCER
Prostate cancer (PC) is the most commonly found malignancy among men globally. Many genetic and epigenetic factors involving multiple cellular signaling networks are implicated in the initiation, progression, and metastasis of this disease. Therapeutic drug resistance and hormone-sensitive and/or …
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Investigating a novel small molecule inhibitor of nuclear import as an anti-cancer approach
The identification of novel cancer-associated biomarkers against which drugs can be developed is anticipated to be beneficial in multiple ways; including their use as monotherapies and in combination with current chemotherapeutic agents for improved anti-cancer treatment outcome. Recently, research …
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Synthetic Essentiality of Tdo2 In Apc-Mutated Colorectal Cancer
… is</p> <p>common genetic event across many cancers and serves a critical initiating</p> <p>event in the majority of sporadic colorectal cancers (CRC). The WNT/APC</p> <p>pathway remains an elusive target for cancer, prompting us to explore</p> <p>orthogonal strategies to identify specific …
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Mechanistic and Therapeutic Insights for Epigenetic Regulation in Cancer Development
… proliferation (via Cyclin D1 downregulation) and survival (via BIM induction) may indicate how BRD4 inhibition is exquisitely effective against MPNSTs and may represent a paradigm shift in therapy for MPNST patients. Moreover, these findings indicate an epigenetic mechanism underlying the balance …
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THE EFFECTS OF ACIDOSIS ON SURVIVAL PATHWAYS IN LYMPHOID MALIGNANCIES
… in the field has revealed that, within tumors, cancer cells must grow and develop amidst an increasingly complex and demanding background. Cancer cells acquire the ability to recognize and respond to numerous features of this tumor microenvironment, generating a cellular-environmental crosstalk …
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Characterisation of Small Ubiquitin-like Modifier (SUMO) protein complex expression in human cancer cells to identify novel therapeutic targets
… of the target proteins and contribute to various cellular functions essential for cancer cell survival and proliferation. The unique behaviours, phenotypic and molecular adaptations found in the naked-mole rat (NMR) suggest a high stability and effective functioning of the molecular machinery that …
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Mutations in a Mechanosensitive Channel Enable Intravascular Metaststic Cell Survival
… sequencing technology has revolutionized cancer biology by accelerating the unbiased discovery of mutations across human cancers 1-4. Despite this advance, it remains unknown whether there exist mutations that function specifically to drive steps in the metastatic cascade independent from, …
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Enzymatic crosslinking of dynamic hydrogels for in vitro cell culture
Stiffening and softening of extracellular matrix (ECM) are critical processes governing many aspects of biological processes. The most common practice used to investigate these processes is seeding cells on two-dimensional (2D) surfaces of varying stiffness. In recent years, cell-laden …
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Design, Synthesis, & Biological Evaluation of Novel Het-Aromatic/Aromatic Analogs for the Treatment of HIV, Cancer, & Cognitive Dysfunctions
… signaling cascades plays a critical role in cancer cell survival, metastasis, and chemo-resistance. The MEK5/ERK5 pathway, which is a member of MAPK signaling cascade, is involved in cell survival, anti-apoptotic signaling, angiogenesis, and cell motility. It is found to be significantly …
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Pyrimidine nucleotide carrier 1 in mitochondrial homeostasis and cancer
Abnormal metabolism has been a known feature of cancer for close to a decade, with mitochondrial dysfunction, aerobic glycolysis, and abnormal biosynthetic metabolism present in many cancers. Dysfunctional mitochondria alone have been shown to significantly influence cancer phenotype. Mitochondrial …
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Nutrient-dependent effects of the autophagy-lysosomal inhibitor, Chloroquine, on cell death and lysosomal functionality
There is huge potential for targeting pro-survival autophagy as a cancer therapeutic strategy, but this approach has not yet been fully realised due to the complex involvement of autophagy for cancer biology. In early stages of transformation, autophagy acts as a tumour suppressor, whilst in a …
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Insights into the role of PFKFB3 in cancer
… isoform of PFK-2, which is highly expressed in cancer cells, has been suggested to be associated with enhanced aerobic glycolysis in cancer by elevating the intracellular levels of key glycolytic activator, Fru-2,6-P2. This work describes the importance of PFKFB3 function in metabolic …
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