Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"cancer cell signaling"”.
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Molecular Mechanisms Of Pressure-Stimulated Cancer Cell Signaling
… <p>MOLECULAR MECHANISMS OF PRESSURE-STIMULATED CANCER CELL SIGNALING</p> <p>by</p> <p>CHRISTINA DOWNEY</p> <p>June 2010</p> <p>Advisor: Dr. Marc Basson, MD, PhD</p> <p>Major: Cancer Biology</p> <p>Degree: Doctor of Philosophy</p> <p> Increased extracellular pressure stimulates cancer cell …
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Exploring the mechanism of SHP2 and EGFR/HER2 cooperation in breast cancer cell signaling
… has been established as a critical mediator of cancer-related cell signaling downstream of receptor tyrosine kinases like EGFR and HER2. As such, targeting of SHP2 is being recognized as a potentially viable therapeutic option in HER2-positive and triple-negative breast cancers. In this report, …
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Evaluating The Therapeutic Efficacy of Grb2 Inhibition In Ovarian Malignancies
… protein-2 (Grb2) play important roles in cancer cell signaling. In the present study, we examined the biological effects of liposomal antisense oligodeoxynucleotide that blocks Grb2 expression (L-Grb2) in ovarian cancer models.</p> <p><strong>Experimental Design: </strong>Murine orthotopic …
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Phenothiazines Induce Abortive Autophagy Leading to Cancer Cell Death
… and environmental stresses for the survival of cells by delivering cytoplasmic contents to the lysosomes for recycling and energy generation. Dysregulation of this process has been linked to human diseases including immune disorders, neurodegenerative muscular diseases and cancer.</p> …
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Regulation of Clathrin Mediated Endocytosis and Its Role in Cancer Progression
Metastasis is a multistep process requiring cancer cell signaling, invasion, migration, survival, and proliferation. These processes require dynamic modulation of cell surface proteins by endocytosis. Given this functional connection, it has been suggested that endocytosis is dysregulated in …
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Bioimage informatics for understanding the effects of chemotherapy on cellular signaling, structure, and function
… but its effects are often associated with cancer relapse, metastasis, and drug resistance. The biological mechanisms that drive the structural and functional changes in cancer cells associated with these features of disease progression remain poorly understood. Consequently, quantitative …
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Biomechanical regulation of cancer metastasis
Metastasis is the ultimate cause of most cancer-related deaths. As such, it is critical to understand the processes that control the spread of cancer through the body. To metastasize, cancer cells must leave the primary tumor, access the circulatory system, adhere to the endothelium of the …
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Gsk3 Mediates Signaling Upstream of Akt
The phosphatidylinositide 3 kinase (PI3K)/Akt signaling network plays a pivotal role in multiple cellular functions. PI3K links the extracellular growth factor receptors to the serine-threonine kinase Akt which, through phosphorylation of numerous intracellular proteins, mediates increased cell …
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BASIGIN-2 MEDIATED ACTIVATION OF ERK1/2 SIGNALING IN HUMAN GLIOBLASTOMA MULTIFORME CELLS
… is the most common malignant form of human brain cancer. GBM tumor cells overexpress the protein Basigin (Bsg) at the cell surface where it contributes to malignancy via stimulation of matrix metalloproteinase (MMP) expression in surrounding normal tissues, resulting in the degradation of the …