Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 49 for “"cancer cell migration"”.
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The role of PAK6 in HGF-induced prostate cancer cell migration
Cell migration plays a significant role in carcinoma metastasis in which cancer cells move from the primary site and establish tumours at a secondary location. During tumour progression cancer cells can assume a migratory phenotype which is characterised by cell-cell dissociation and single cells …
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Molecular Study of Gβγ Dependent Breast Cancer Cell Migration and Invasion
… oncogenic pathways, thus suppressing prostate cancer formation and growth. In addition, an inhibitor of the Gα/Gβγ protein complex has been shown to have anti-tumor activity. Thus Gβγ subunits may function as potential links between GPCRs and tumor transformation and growth. The aim of the …
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Mechanotransduction of subcellular AMPK and its role in breast cancer cell migration
… the tumor site has significant impact on breast cancer progression and metastasis. The importance of altered mechanotransduction in cancerous tissue through the integrin-mediated signaling axis has been documented, yet its role in the regulation of cellular metabolism and the potential link …
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Recapitulating mammary gland development and breast cancer cell migration in vitro using 3D engineered scaffolds
… epithelium of luminal and myoepithelial cells surrounded by an adipocyte-rich fat pad, a highly collagenous extra-cellular matrix (ECM) and a number of other stromal and endothelial cell types. Mammary stem cells (MaSCs) reside within the epithelium and these are capable of repopulating a …
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The role of VEGF-induced PI3K/Akt signalling pathway in head and neck cancer cell migration
… pathway is a well-established driver of cancer progression. One key process promoted by Akt phosphorylation is tumour cell motility; however the mechanism of VEGF-induced Akt phosphorylation leading to motility remains poorly understood. Previously, it has been shown that Akt …
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Snail1-mediated Gene Repression Links EMT to Enhanced Biliary Epithelial Cell Survival and Lung Epithelial Cancer Cell Migration
Liver fibrosis and cancer metastasis remain significant health problems, with a mortality rate of nine million each year worldwide. Effective therapies for these problems are very limited due to lack of a clear understanding of the underlying mechanisms. Epithelial-mesenchymal-transition (EMT) is a …
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EXPLORING THE ALLOSTERIC INHIBITION MECHANISM OF HUMAN KIDNEY TYPE GLUTAMINASE TO ARREST CANCER CELL PROLIFERATION AND INVESTIGATING HAKAI MEDIATED UBIQUITINATION TOWARDS CONTROLLING CANCER CELL MIGRATION
The development and progression of cancer can be associated with certain hallmarks. Two among them are the altered cell metabolism (Warburg effect), and cancer cell invasion/progression mediated by post-translational modulation of cell signaling. In this thesis we have attempted to explore these …
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Tumor microenvironmental control of metastasis : effects of the immune cells and physical forces on cell migration
Metastasis, which accounts for 90% of cancer deaths, critically depends on the ability of cancer cells to migrate through the dense extracellular matrix (ECM) surrounding the solid tumor. Recent advances in cancer biology have revealed that non-cancerous cells and biophysical forces in tumor …
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Exploring Chemical Crosslinking of the Extracellular Matrix as a Potential Therapy for Recurrent Glioblastoma
Glioblastoma (GBM) is a type of cancer that originates from the glial cells of the brain and is difficult to treat due to the diffuse nature of the tumour. The recurrence of GBM at the surgical site is a significant problem after surgery. Filling the surgical cavity with saline and oedema occurring …
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Characterization of perillyl alcohol as a cell migration-inhibiting compound
Inhibiting cancer cell migration could greatly improve the prognosis of cancer patients. Prior to commercialization of the Plopper laboratory designed a 96-well plate, we optimized our in vitro migration and cell viability assays to meet the standards set by the National Cancer Institute for use in …
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Breast Cancer Cell Mechanical Properties and Migration on Collagen I Matrices with Tunable Elasticity
Unlike their normal counterparts, breast cancer cells break free from epithelia and invade the underlying stroma, leading to deadly metastases. Cell migration requires mechanical interactions between the intracellular cytoskeleton and the extracellular matrix. The goals of this work were to compare …
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Regulation of Breast Cancer Cells’ Bone-Metastatic Potential by Mechanically Stimulated Osteocytes
Bone metastasis, the migration of cancers to the bone, occurs in 65-75% of patients with advanced breast cancer and significantly increases patients’ morbidity and mortality. The bone-metastatic cancer cells interact with cells in the bone to disrupt the bone remodeling balance, causing reduced …
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Cancer cell behaviour following parasite exposure
… are estimated to cause 16.1% of global cancer cases. While certain helminths are conclusive causes of cancer, others have been shown to reduce the disease. It is currently unknown why differing helminth infections promote or prevent cancer development and progression, or which cellular …
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Deubiquitinating Enzymes Promote Cancer Progression and Metastasis Via Regulating Protein Stability
… target proteins. DUBs have critical roles in cell homeostasis and signal transduction, as they regulate protein degradation, subcellular localization, and protein-protein interaction. Deregulation of DUBs contributes substantially to tumor formation and progression, and therefore targeting …
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TIS21 inhibits cell migration by downregulating expression of matrix metalloproteinases
… is the mouse homolog of rat pheochromocytoma cell 3 (PC3) and human B-cell translocation gene 2 (BTG2). TIS21 regulates cell cycle progression and proneural genes expression by acting as a transcription coregulator that enhances or inhibits the activity of transcription factors. And In human …
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The Roles of Rap1 in Cancer Metastasis and Pancreatic Islet Beta Cell Function
… is still unclear. Rap1 has been implicated in cancer tumorigenesis, but its role in cancer invasion and metastasis is less understood. Rap1 signals to pathways involved in cell adhesion, migration, and survival, suggesting that Rap1 may promote several processes associated with metastasis. …
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TIS21 inhibits cell migration and invasion
… suppressor gene and frequently downregulated in cancer tissue. In human tissue, decreased BTG2 is correlated with cancer cell metastasis, suggesting that suppression of BTG2 has a critical role in cancer cell migration and invasion. When we overexpressed TIS21 in A549 cells, cell migration and …
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Cancer Protrusions on a Tightrope - Suspended Fiber Platform Reveals Protrusion Dynamics Independent of Cell Migration
Indispensable to all modes of migration used during single cell metastasis, cytoplasmic protrusions are pivotal in surveying cells local surroundings which ultimately initiates migration of the cell body. Cancer cell migration is fairly well studied with the traditional focus on protrusion driven …
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Crosstalk between colorectal cancer cells and tumour-associated macrophages
Colorectal cancer (CRC) is the third most common cancer and the fourth leading cause of death from cancer worldwide. People suffering from inflammatory bowel disease, such as Crohns’ disease and ulcerative colitis, are at an increased risk of developing CRC. The development of CRC is highly …
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Upregulation of PIP3-dependent RAC Exchanger 1 (P-Rex1) Promotes Prostate Cancer Metastasis
… factors (GEFs) at the leading edge of the cell plays an important role in directional cell migration, a critical step of tumor metastasis cascades. We investigated the role of P-Rex1, a novel specific GEF for Rac, in human prostate cancer metastasis. P-Rex1 expression (mRNA and/or protein) …
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