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Showing 1 to 10 of 10 for “"cancer cell metabolism"”.
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ROLE OF LYSOPHOSPHATIDIC ACID IN REGULATION OF CANCER CELL METABOLISM
… its proliferative and migratory activities in cancer cells. Strong evidence suggests that LPA production and expression of its receptors are dysregulated in multiple human malignancies. The mechanism behind LPA-mediated tumor cell growth and oncogenesis remains poorly understood. In this thesis …
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Metabolic Diversity in Human Non-Small Cell Lung Cancer Cells
Cancer cells display oncogene-driven rewiring of metabolism to produce energy and macromolecules for growth. Inhibition of growth-promoting metabolic pathways may prove to be a useful therapeutic strategy in cancer. However, neither the full breadth of cancer cell metabolic diversity, nor the …
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Gluconeogenic FBP1 plays a key metabolic role in activated T cells
… is active in liver, kidney and skeletal muscle cells. This study suggests that FBP1 plays a novel non-gluconeogenic role in T cells. Targeted metabolomics using [13C]-6-glucose revealed a labeling pattern of F6P in stimulated CD3+ T cells that could only have resulted from FBP1 enzymatic …
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Investigation of Divergent Metabolic Programs in the Tumor-Immune Microenvironment
The current immune metabolism field has been using the term lactate and lactic acid interchangeably, with the notion that lactate and lactic acid are waste products of highly glycolytic cancer cells that negatively affects TIL function and viability to promote tumorigenesis. However, it is yet …
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Metabolic-response assessment of metastatic murine breast cancer in 2D and 3D cultures using intrinsic NADH as a natural biomarker
The majority of in vitro studies of living cells are routinely conducted in a two-dimensional (2D) monolayer culture towards pathophysiological investigation, drug screenings, and cancer diagnostics. There is strong evidence, however, that suggests cellular behavior and metabolism in 2D cell …
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유전자 적중법을 이용한 조건적 LDHB 유전자 삭제 마우스 제작
In general, differentiated cells produce most of the ATP to growth from glucose through metabolism. Normal cells produce 2 ATP by glycolysis in the cytoplasm and convert to 2 pyruvates. Next, this pyruvate produces about 36 ATP by oxidative phosphorylation in the mitochondria. On the other hand, …
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DIFFERENTIAL EFFECTS OF GROWTH FACTORS ON GLYCOLYSIS IN OVARIAN CANCER CELLS
… levels in the blood and ascites of ovarian cancer patients. LPA is a ligand of seven cell surface G protein-coupled receptors. It has been known as an oncogenic growth factor in ovarian cancer and other types of human malignancies. However, the precise biological functions of LPA in ovarian …
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Molecular Effects of the Nampt Inhibitor FK866 on Leukemia Cells
… has emerged as an hallmark of proliferating cancer cells and pharmaceutical approaches targeting cell metabolism hold great potential for cancer treatment. A critical factor in cellular metabolism is nicotinamide adenine dinucleotide (NAD+) and cancer cells highly rely on it to face increased …
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HYPOXIA-REGULATED EXPRESSION OF GLUT-1 IN GBM CELL LINES
<p>Unlike normal cells, cancer cells can grow in low oxygen (hypoxic) environments. Changes in relative oxygen concentration can alter gene expression in tumors to allow for their selective growth. The result of such changes allows the tumor to adapt its cellular metabolism and promote tumor …
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The Bca2 And Ampk Paradigm: Unraveling The Cancer Connection
… <strong>THE BCA2 & AMPK PARADIGM: UNRAVELING THE CANCER CONNECTION</strong> </p> <p>By</p> <p> <strong>DANIELA (BUAC) VENTRO</strong> </p> <p>December 2013</p> <p>Advisor: Dr. Q Ping Dou and Angelika M. Burger (deceased)</p> <p>Major: Cancer Biology</p> <p>Degree: Doctor of Philosophy</p> …