Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 706 for “"cancer cell lines"”.
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Cytochrome P450 mRNA profile in human breast cancer cell lines.
Cytochrome P450 enzymes (P450s) are involved in cancer development and treatment due to their roles in the oxidative metabolism of various compounds, both endogenous (e.g. oestrogen) and exogenous (e.g. tamoxifen). Intermediate P450 metabolites derived from oestrogen metabolism are associated with …
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Cytotoxic Effects of Ruthenium Compounds on Human Cancer Cell Lines.
<p>Chemotherapy is the most common cancer treatment. Traditionally, platinum-based drugs are used in chemotherapy. More recently, researchers have focused on ruthenium based compounds as a substitute for the platinum compounds. Ruthenium-based compounds appear to be less toxic to healthy cells than …
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Glycosylation of Prostate Cancer Cell Lines and Glycosyltransferase Characterization and Inhibition
Altered glycosylation is a hallmark of cancer and can be used to distinguish cancer cells from normal cells. This thesis shows a comprehensive study of glycosylation on a variety of human prostate cell lines. Cell surface glycans were analyzed using lectins and antibodies. Glycans were also …
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Chemical characterisation of grapevine waste and bioactivity on cancer cell lines
… solvent extracts were determined using the non-cellular assays, DPPH and phosphomolybdenum assay. In general red skin and stem extracts had a higher phenolic, flavonoid and total antioxidant activity than white skin and stem extracts, with no significant difference between red and white cultivar …
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Characterisation and modulation of drug resistance in lung cancer cell lines
… is a major obstacle in the treatment of cancer. It can result from an increase in levels of cellular drug efflux pumps such as P-glycoprotein (P-gp). Using cellular models, this thesis aimed to investigate resistance in lung cancer cells while developing siRNA and membrane proteomic …
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Integration of Multiple Data Types for Analysis of Cancer Cell Lines
Cancer cell lines play an important and critical part in oncology research. The advances in understanding of cancer biology which were achieved in the last few decades would be virtually impossible without using cancer cell lines as research models. Therefore better understanding of molecular …
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Molecular Basis of Adaptation of Enteroviruses to Different Cancer Cell Lines
Viral oncolytic therapy, a novel treatment for cancer using specially designed viruses to kill malignant cells while leaving normal cells unharmed, is currently under intense investigation. Several receptors are up-regulated in cancer cells, including decay-accelerating factor (DAF; CD55) and …
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JNK regulates Fas receptor mediated apoptosis in prostate cancer cell lines
Prostate Cancer is a disease that primarily affects elderly men. The incidence of prostate cancer has been progressively increasing in the western world over the last two decades. Life expectancy and diet are believed to be the main factors contributing to this increase in prevalence. Prostate …
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Screening for apoptosis in breast cancer cell lines using gel electophoresis
Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Nuclear Engineering, 1995.
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The effect of potential anticancer gene products on breast cancer cell lines
Cellular or viral delivery of anti-cancer gene therapeutics typically has been investigated as single agents. More recently combinatorial agents have been investigated for which some combinations have shown synergism. The present study was designed to evaluate three different potential anticancer …
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Identification and functional characterisation of gene fusions in human cancer cell lines
… of gene fusions such as EML4-ALK in lung cancer and BCR-ABL1 in chronic myeloid leukaemia have already led to changes in clinical care. However, important questions remain about the role of gene fusions in promoting oncogenic phenotypes and their relevance in drug response. In this study, …
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The effects of snake venoms as cytotoxins on selected prostate cancer cell lines
Cancer is expected to claim 9 million deaths world-wide by the year 2020. Although there has been an increase in the sophistication of current therapeutic strategies, 40% of patients are still likely to die from the disease. Novel anticancer compounds are needed. Snake venoms may represent a …
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Exploring the in vitro effects of chronic methamphetamine exposure on selected cancer cell lines
… well documented in multiple organ systems, the cellular consequences of chronic METH exposure in cancer biology remain poorly defined. Understanding how tumour cells respond to sustained psychostimulant-induced stress may provide insight into metabolic and redox adaptations relevant to cancer …
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Cytotoxic effects of electron carriers are inhibited by Hsp27 in breast cancer cell lines
Human breast cancer cell lines DC4, DB46, MCF-7, MDA-MD-435 were incubated with cytochrome c at 5 x 10-7M, 5 x 10 -6M and 5 x 10-5M. Human colon cancer cell line, RKO, and normal human lung fibroblast cell line, HFL1, were incubated with cytochrome c at 5.6 x 10-8M, 5.6 x 10-7M and 5.6 x 10-6M. …
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Investigations into altered cellular glycosylation associated with metastatic competence in breast cancer cell lines
Metastasis is the main cause of cancer patient death owing to the fact that metastatic disease is difficult to treat. Aberrant glycosylation is characteristic of cancer and plays a role in metastatic mechanisms. HPA, a lectin from the Roman snail Helix pomatia, recognises glycans terminating in …
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Anti-cancerous and anti-metastatic effects of Corchorus Olitorius on breast cancer cell lines
Breast cancer is one of the leading conditions affecting women worldwide, with a high incidence and mortality rate, including Cyprus. Several factors contribute to the development of breast cancer. These include genetic predisposition, reproductive health and modifiable factors such as dietary …
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An evaluation of cancer biomarkers in normal ovarian epithelial cells and ovarian cancer cell lines
… are over 190,000 new reported cases of ovarian cancers per annum. This comprises 3% to 4% of all cancers in women. Ovarian cancer is one of the leading causes of deaths in women. Ovarian cancer is the second most diagnosed gynaecological malignancy and over all the fifth cause leading to death …
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“Differential regulation of PTHrP gene expression by 1,25(OH)2D3 in prostate cancer cell lines”
… protein (PTHrP) is expressed by prostate cancer cells. Since PTHrP enhances the growth and osteolytic potential of prostate cancer cells, it is important to control PTHrP expression in these cells. 1,25-Dihydroxyvitamin D3 (1,25(OH)2D3) downregulates PTHrP expression in a variety of human …
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