Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 1440 for “"cancer cell"”.
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Estrogen in ovarian cancer cell metastasis
… tumors and majority of epithelial ovarian cancers possess steroid receptors including estrogen receptors (ERs). However, the estrogen-ER signaling in ovarian carcinomas is not completely understood. Tumorigenesis is a multiple-step process involving dysregulated cell growth and metastasis. …
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Cancer cell behaviour following parasite exposure
… are estimated to cause 16.1% of global cancer cases. While certain helminths are conclusive causes of cancer, others have been shown to reduce the disease. It is currently unknown why differing helminth infections promote or prevent cancer development and progression, or which cellular …
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Androgen Receptor and Prostate Cancer Cell Heterogeneity
… (AR) plays an important role in prostate cancer (PCa) development and has been the main therapeutic target in advanced PCa. AR expression is heterogeneous in both primary PCa and castration resistant prostate cancer (CRPC). However, the functional significance of AR heterogeneity in …
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Single cancer cell detection with optofluidic intracavity spectroscopy
The detection of cancer cells is the basis for cancer diagnostics, cancer screening and cancer treatment monitoring. Non-destructive and non-chemical optical methods may help reduce the complexity and cost of related test, making them more available to the public. The label-free technique of …
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Molecular Mechanisms Of Pressure-Stimulated Cancer Cell Signaling
… <p>MOLECULAR MECHANISMS OF PRESSURE-STIMULATED CANCER CELL SIGNALING</p> <p>by</p> <p>CHRISTINA DOWNEY</p> <p>June 2010</p> <p>Advisor: Dr. Marc Basson, MD, PhD</p> <p>Major: Cancer Biology</p> <p>Degree: Doctor of Philosophy</p> <p> Increased extracellular pressure stimulates cancer cell …
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Downregulation of Pax2 Suppresses Ovarian Cancer Cell Growth
… genes regulating tissue development and cellular differentiation in embryos. <em>PAX2</em> promotes cell proliferation, oncogenic transformation, cell-lineage specification, migration, and survival. Unattenuated <em>PAX2</em> has been found in several cancer types. We therefore sought to …
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Cell cycle perspectives on breast cancer cell behaviour
… important characteristics of aggressive tumour cells. Previous observations in both colorectal cancer and basal cell carcinoma indicated that infiltrative tumour cell behaviour might be counteracted by a high proliferative activity, suggesting a coordination of these two activities at the …
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Regulation of Breast Cancer Cell Proliferation by APRIL
Breast cancer is the most common cause of death from cancer among women. “A proliferation-inducing ligand” (APRIL) is seen in the stroma of approximately 38% of breast cancer patients. APRIL is a tumor necrosis factor superfamily member that is implicated in lymphoid cell survival, proliferation …
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Investigating Novel Targets to Inhibit Cancer Cell Survival
Cancer remains the second leading cause of death in the United States and the world, despite years of research and the development of different treatments. One reason for this is cancer cells are able to survive through adaptation to their environment and aberrantly activated growth signaling. As …
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Proteomic Map of ER+ Breast Cancer Cell Cycle
Cancer is characterized by a deregulation of the cell cycle resulting in abnormal proliferation of cells that can bypass tightly regulated molecular checkpoints. Breast cancer is the most common cancer diagnosed in women, ~70% of cases displaying an estrogen receptor positive (ER+) phenotype. The …
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Probing the Molecular Requirements for Breast Cancer Cell Motility
Invasion of breast cancer cells into the stroma is an early step in metastasis. How invasive ability is conferred in breast cancer cells is poorly understood. It has been shown that the tumor microenvironment can assist in the progression of cancer. The mechanism by which the microenvironment, …
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Phenothiazines Induce Abortive Autophagy Leading to Cancer Cell Death
… and environmental stresses for the survival of cells by delivering cytoplasmic contents to the lysosomes for recycling and energy generation. Dysregulation of this process has been linked to human diseases including immune disorders, neurodegenerative muscular diseases and cancer.</p> …
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Cancer cell invasion: Guidance in interstitial and muscle tissue
Contains fulltext : 250082.pdf (Publisher’s version ) (Open Access)
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Cancer Cell Mechanics in Chemoresistance and Chemotherapeutic Drug Exposure
Cancer remains a problem worldwide as one of the leading causes of morbidity and mortality. Many cancer patients experience recurrence and ultimately death due to treatment failure or the development of chemoresistance. The concept of chemoresistance however is complex, recent studies have …
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Development of a Dielectrophoresis-Based Cancer-Cell Analysis Tool
One significant obstacle in cancer treatment is tumor heterogeneity. Different subpopulations within a tumor can respond differently to chemotherapy, resulting in resistance and recurrence. Addressing these differences while choosing a treatment modality could significantly improve chemotherapy …
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The role of mitochondrial complex II in cancer cell biology
Mitochondrie jsou pro většinu eukaryotických buněk nezbytné organely, které obsahují řadu komplikovaných, vzájemně interagujících proteinových struktur. Mezi ně patří mimo jiné i komplexy elektron transportního řetězce, tedy komplexy I - IV. Mitochondriální komplex II hraje klíčovou roli v buněčném …
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ROLE OF LYSOPHOSPHATIDIC ACID IN REGULATION OF CANCER CELL METABOLISM
… its proliferative and migratory activities in cancer cells. Strong evidence suggests that LPA production and expression of its receptors are dysregulated in multiple human malignancies. The mechanism behind LPA-mediated tumor cell growth and oncogenesis remains poorly understood. In this thesis …
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