Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"cancer biomarker discovery"”.
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Proteomics for cancer biomarker discovery
Background: If we are to successfully treat cancer, we must understand the biologic underpinnings in conjunction with early diagnosis. Genome-wide expression studies have advanced the research of many cancers. Nevertheless, understanding which genes are expressed in a tumor is not equivalent to …
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The Role of Proteomics in Colorectal Cancer Biomarker Discovery
Colorectal cancer is one of the most prevalent cancers within the UK and has a steadily rising incidence. If detected early Colorectal Cancer (CRC) is highly curable, but currently only 9% of patients present when the cancer is in the earliest stages (Dukes Stage A). The unique characteristics of …
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Differential Network Analysis based on Omic Data for Cancer Biomarker Discovery
… groups (disease cases vs. healthy controls) for cancer biomarker discovery. However, differential expression analysis on independent studies for the same clinical types of patients often led to different sets of significant biomolecules and had only few in common. This may be attributed to the …
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Topic Model-based Mass Spectrometric Data Analysis in Cancer Biomarker Discovery Studies
… and cellular mechanisms may reveal useful biomarkers for human diseases including cancers. High-throughput omic technologies for identifying and quantifying multi-level biological molecules (e.g., proteins, glycans, and metabolites) have facilitated the advances in biological research in …
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Bioinformatics analysis of epigenetic variants associated with melanoma
The field of cancer genomics is currently being enhanced by the power of Epigenome-wide association studies (EWAS). Over the last couple of years comprehensive sequence data sets have been generated, allowing analysis of genome-wide activity in cohorts of different individuals to be increasingly …
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A novel genomic approach to multiple cancer diagnostics using mutations in blood bound EV RNA: Machine Learning Methods For Biomarker Detection and Protein Mutation Assessment
Identification of biomarkers is critical for early detection of cancers such as pancreatic ductal adenocarcinoma (PDAC), which is often diagnosed in later stages. Extracellular vesicles (EVs) released into the blood from tumour cells make good biomarkers for this purpose by protecting their …
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Biomarker discovery using urinary metabolomics for noninvasive early cancer detection
… new screening methods for the early detection of cancer remains one of the foremost challenges facing modern cancer research. The emergence of new analytical technologies and their application to 'omics'-based approaches has provided researchers with powerful new tools for molecular biomarker …
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Integrating High-throughput Technologies for the Identification and Validation of Novel Ovarian Cancer Biomarkers
Ovarian cancer is the most lethal gynaecological malignancy in North America. Although survival rates are high when the disease is diagnosed at an early stage, this decreases significantly in late-stage diagnoses. The majority of cases are of epithelial origin, which can be classified into four …
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Prostate Cancer and the Search for Novel Biomarkers
… this research project was to identify prostate cancer (PCa) -specific biomarkers from urine. This was done using a multi-faceted approach that targeted (1) the genome (DNA); (2) the transcriptome (mRNA and miRNA); and (3) the proteome. Toward this end, urine samples were collected from ten …
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Exosomes and miRNAs in disease pathogenesis and opportunities for molecular targeting
… of release, making them promising candidates for biomarker discovery. The contents of exosomes are protected by a lipid bilayer, leading to better stability of bio-macromolecules. Recent evidence suggests a novel role for exosomes as conveyors of information among cells and across tissues, through …