Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"cancer antigen"”.
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Structure and Function of KH Domain in DDX43 and DDX53 Cancer Antigen Helicases
DDX43 and DDX53 are two cancer/testis antigens that are overexpressed in various tumors, but absent or expressed at very low levels in normal tissues; therefore, both are proposed to be valid candidates for therapeutic targets. DDX43 and DDX53 belong to the DEAD-box RNA helicase family, and contain …
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The Association between Serum Cancer Antigen 125 (CA 125) and Risk of Lung Cancer in Females: Assessing the Possibilities for Early Detection
… the relationship between CA 125 and lung cancer. This study is expected to provide more understanding about CA 125 and its role as a potential predictor for lung cancer risk. Objectives: To evaluate: i) the association between CA 125 and lung cancer; ii) if the associations differ by …
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A New Immunoassay for Quantification of a Novel Cancer Antigen in Serum and Immunostaining of Carcinoma Tissues and Cultured Cells Revealing the Antigenic Cellular Location.
… this study is 1) to examine the presence of the antigen in serum by employing a newly developed ELISA immunoassay that quantifies the total antigen and bound antigen (antigen-antibody complex) using polyclonal chicken antibodies directed against an IgM-binding epitope of the new antigen, and 2) …
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The isolation and characterisation of MHC-presented peptides from CML-derived cell-lines, with a focus on post-translational modification
… MHC-presented phosphopeptides may reveal unique cancer antigens with direct links to the neoplastic state. Mild acid cell-surface elution is a rapid and effective method for MHC class-I peptide capture, though complicated by contamination with non-MHC peptides and poor downstream compatibility, …
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Cancer immunotherapy with Mucin-1 and cytokines
Cancer immunotherapy involves the manipulation of the immune response to combat tumour cells. The studies contained within investigated the role of cytokines in the anti-tumour immune response to the cancer antigen, MUCl, which is over produced in an altered form in cancers of the breast, pancreas, …
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Protein engineering for targeted delivery of radionuclides to tumors
Traditional cancer treatment strategies include systemic chemotherapy, external beam radiation, and surgical excision. Chemotherapy is nonspecific, and targets all rapidly dividing cells. External beam radiation and surgery only target known cancer sites. However, targeted therapeutics, such as …
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Ovarian cancer serum biomarker discovery using proteomics
Ovarian cancer is a lethal gynaecological malignancy which is known as the silent killer. It has a poor prognosis due to the lack of major symptoms in early stage disease and hence its late detection. Cancer antigen-125, the most widely used biomarker for ovarian cancer detection, lacks appropriate …
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병원직원의 저선량 방사선 피폭과 혈액검사 결과의 연관성
… 표지자 검사인 α-feto protein(AFP), Carcino-Embrionic Antigen(CEA), Prostate-Specific Antigen(PSA), Cancer Antigen(CA-125), 그리고, 갑상선 호르몬 검사인 Thyroil Stimulating Hormone(TSH), Free T4(FT4) 검사 결과를 사용하였다. 분석에 사용된 통계분석 방법은 t-test, ANOVA, 다중회귀분석을 실시하였고, 다음과 같은 결론을 얻었다. 방사선 관계 종사자의 평균 피폭선량은 남자가 …
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Molecular display of synthetic oligonucleotide libraries and their analysis with high throughput DNA sequencing
… model (HMM) that was trained on all antibody-antigen co-crystal complexes present in the Protein Data Bank. The resultant ~10¹² member library has been produced in ribosome display format, and was comprehensively analyzed over four rounds of antigen selections by multiplex paired-end Illumina …
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Quantitative cellular and molecular imaging of the intact tumor microenvironment.
… of tumor-associated immune responses in cancer are not well defined and are likely multifactorial including cancer cell heterogeneity, host genotype, and the immune status of individual patients. Tumors are complex and organized tissues that include multiple cell types, which together …
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Modulating Immunometabolism to Improve The Activity of Car-Nk Cells Targeting Cd70 In Renal Cell Carcinoma
… of action are urgently needed. Chimeric antigen receptor (CAR) T-cell therapy has shown remarkable responses in hematologic malignancies, but many obstacles hinder success in solid tumors including the paucity of highly specific targets and the hostility of the tumor microenvironment …
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Identifying genetic biomarkers for diagnosis of prostate cancer in South African men
Background and Aim: Prostate cancer (PCa) is the leading cancer diagnosis amongst South African men. The incidence of PCa is 68.0 per 100 000 Age Standardized Rate (ASR) and the mortality rates are 27.9 per 100 000 ASR; Globocan 2018. Diagnosis of PCa is based on a combination of digital rectal …
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Proteomic Profiling of Serum Derived Exosomes from Prostate Cancer Patients
… in the diagnosis and management of Prostate cancer (PCa) in the past few decades has been, the dramatic decline of men with advanced/metastatic PCa at diagnosis coupled with a significant improvement ( >90%) in the five and ten year survival rates of the disease. Non-palpable PCa (potentially …
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The Utility of CA125 for the Detection of Ovarian Cancer in Primary Care
Background Ovarian cancer is the 6th most common cancer to affect UK women and has the worst prognosis of any gynaecological cancer. Most women are not diagnosed until the disease is advanced, which leads to poor outcomes. Earlier ovarian cancer diagnosis has the potential to improve these …
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An immunoproteomic approach to identifying cancer-associated autoantibody biomarkers
Cancer is a heterogenous disease capable of forming and spreading in most tissues of the human body. Cancer screening and diagnosis can be performed through medical procedures, which are highly invasive, requiring an intensive infrastructure. It is therefore important to create cost-effective, …
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Engineering and characterizing human T cell receptors for cancer immunotherapies
… CDR3), which interact with the peptide (pep)MHC antigen. The conserved docking angle of the six CDRs over the pepMHC antigens is thought to confer maximal signaling capabilities and it places the two most hypervariable loops (CDR3s) over the most diverse portion of the antigen (the peptide). …
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Engineering and characterization of human single-chain T cell receptors
… the cell surface. This class of MHC-restricted antigens provides the broadest class of potential disease targets, as the peptides displayed are derived from the full antigenic repertoire of the cell, including intracellular, secreted, and cell-surface proteins. These peptides can be from …