Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 33 for “"cancer (medicine)"”.
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Robust and interpretable high-dimensional machine learning for predictive cancer medicine
… meaningful biological patterns. In predictive cancer medicine, it is common to employ linear dimensionality reduction methods due to their inherent interpretability. However, recent advances in machine learning have sparked considerable interest in more flexible, non-linear dimensionality …
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Evaluating Cost Effectiveness of Precision Cancer Medicine Approaches and The Economic Burden of Colorectal Cancer
As the understanding of the biology of cancer intensifies, biomarkers with the potential to guide precision cancer medicine (PCM) are discovered with increasing regularity. Yet the cost-effectiveness of the biomarker-guided PCM strategy is rarely evaluated. Utilising colorectal cancer (CRC) as a …
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Communicating Cancer: From Concepts to Care
… and communicative challenges in contemporary cancer medicine centred around precision oncology, an approach which seeks to individualise cancer treatment using genomic biomarkers. Chapter 1 introduces precision oncology, proposing a definition that captures its novel and distinctive features, …
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Pengaruh ekstrak etanol daun widuri terhadap gambaran histologis fibrosarkoma mencit (Mus musculus) jantan yang diinduksi 7,12- Dimetilbenz(A)antrasena (DMBA) secara In vivo
… plants which are used by people as traditional medicine, for example as toothache medicine, poison antidote, feverish medicine and asthma cough. However this plant also can used as cancer medicine. Calotropis gigantea contains compound cardenolide which have cytotoxic concerning cancer cell …
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From Sin to Science: The Cancer Revolution of the Nineteenth Century
… the development of a novel, radical approach to cancer that continues into the twenty-first century. From the 1870s to the 1890s, physicians and the public came to understand cancer in an entirely new light, founded upon the application of scientific principles, methods, and instruments to cancer …
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Personalized Decision Modeling for Intervention and Prevention of Cancers
<p>Personalized medicine has been utilized in all stages of cancer care in recent years, including the prevention, diagnosis, treatment and follow-up. Since prevention and early intervention are particularly crucial in reducing cancer mortalities, personalizing the corresponding strategies and …
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A Clinical Characteristics of Adverse Drug Reaction in Pediatrics
… 8%), Phenytoin (12 patients, 12%), Anti-cancer medicine (4 patients, 4%), Sedative (1 patient, 1%) and Antiflammatory (1 patient, 1%). For 16 patients among them, drug challenge test was performed. As a result, the drugs that have shown positive reaction were NSAID (6 patients, 38%), …
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Bioactivity evaluation of peptide QUB-1480 from the skin secretion of the Green Cascade frog (Odorrana livida)
… bioactivity aiming at microorganism killing, cancer diminishing or protease inhibiting. The research, therefore, will be focused mainly on the peptides isolated from the skin secretion of the amphibian Odorrana livida.<br/><br/>In this thesis, a novel bioactive peptide, QUB-1480 identified …
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A Screen For Peptides Targeting Chemoresistant Metastatic Triple-Negative Breast Cancer
<p>Cancer metastasis is the principal cause of most cancer-associated morbidities. While radiotherapy, hormone therapy, and novel therapeutic strategies, including immunotherapy, have shown promise in inhibiting tumor growth, chemotherapy remains the mainstay in the clinical management of …
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A general method for studying autocrine signaling and its impact on cancer cell growth
… in providing self-sustaining growth signals to cancer cells. Since the introduction of the autocrine hypothesis in 1980s, the contribution of autocrine signaling in cancer medicine has been limited to cancer tissues with adequately characterized mitogenic pathways. Its closed-loop nature and …
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Accurate Mutation Annotation and Functional Prediction Enhance The Applicability of -Omics Data In Precision Medicine
… for enhancing the accuracy and efficiency of cancer patient management and therefore achieve the goals of personalized therapy. However, the accuracy of large scale sequencing data in clinics has been constrained by many different aspects, such as clinical detection, annotation and …
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Modeling of Cns Cancer With A Focus On The Immune Component
<p>The knowledge surrounding cancers of the central nervous system remains poorly developed, in particular with regard to the immune component. The works contained in this thesis look at craniopharyngioma, glioblastoma, and several forms of brain metastasis. While some attention is given to the …
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Ikkalpha Mediated Notch1 Activation Promotes Tumorigenesis Via Foxa2 Suppression
… angiogenesis, and tumor metastasis in many cancers. However, the mechanism of TNFa-mediated tumor development remains unclear. Here, we show that IKKa, an important downstream kinase of TNFa, interacts with and phosphorylates FOXA2 at S107/S111, thereby suppressing FOXA2 transactivation …
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