Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"camelid"”.
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The Economic Organization of Early Camelid Pastoralism in the Andean Highlands of Bolivia
… systems. The domestication of South American camelids: llamas and alpacas) was associated with the development of specialized pastoralist societies that are still poorly understood. In the central altiplano of Bolivia, during the Formative Period: 1800 BC − AD 400) a cultural complex known as …
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A Paleoethnobotanical Analysis of Three Formative Period Wankarani Sites Located in the Department of Oruro, Bolivia
… people are often cited as an example of early camelid pastoralism in South America. However, research on early camelid pastoralism has ignored the importance of plants, especially the cultivation of domesticated plants in this region. The Wankarani people lived in the central altiplano of the …
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Mammal and bird trackways in the Miocene Horse Spring Formation, Clark County, Nevada
… (camel and carnivore) and avian footprints. Camelid tracks identified are Lamaichnum alfi, Lamaichnum macropodum, and Lamaichnum etoromorphum. Carnivore tracks include canid tracks (Canipeda sp.) and a possible felid track ( Felipeda? sp.). One canid trackway records a c-shaped pattern, which …
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Protein glycosylation by NleB and the secretion of therapeutic nanobody fusions
… T3SS, but instead of secreting a whole effector, camelid nanobodies were fused with signal sequences 20 amino acids in length from effectors that are naturally secreted and examined. An attenuated bacterium with an engineered T3SS was created to secrete the nanobody fusions, and in vivo analyses …
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Developing VHH-based tools to study Ebolavirus infection
Variable domains of camelid-derived heavy chain-only antibodies, or VHHs, have emerged as a unique antigen binding moiety that holds promise in its versatility and utilization as a tool to study biological questions. This thesis focuses on two aspects on developing tools to study infectious …
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Localization of nerve growth factor-β in the stallion reproductive tract
… a protein produced in the reproductive tract of camelids (camels, llamas, and alpacas) that has been identified as the ovulation inducing factor in seminal plasma. NGF-β from seminal plasma deposited into the reproductive tract of the female camelid acts systemically to stimulate secretion of …
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Developing a novel hepatitis B core – based antigen presentation system
… display of single domain antibody fragments of camelid origin (nanobodies, or VHH). The resulting “tandibody” particles, as they are named here, can bind to their cognate antigen to yield CLPs covered in the antigen of interest. Furthermore, it was shown that target antigens can be attached to …
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Cross-reactivity among alphaviruses provides insight into viral emergence and novel defense strategies
… studies, we have characterized the potency of a camelid-derived single-domain antibody (sdAb) that neutralizes a breadth of alphaviruses, including CHIKV and MAYV. With these data, we have designed and generated transgenic Aedes aegypti mosquitoes that express two anti-CHIKV sdAbs to target …
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Using data to characterise the relationship between nanobody sequence, structure and function
… antibody derived from the immune systems of camelid species. They achieve binding affinities and specificities to target antigens comparable to those of classical antibodies (Abs), despite being ten times smaller (~15 kDa) and having only three variable loops. This raises the question of how …
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Development of nanobodies as tools to investigate G-quadruplex DNA secondary structures
… derived from of heavy-chain only antibodies of Camelid family, that have high affinity and selectivity for the G4 structure from the human *MYC* oncogene promoter (MycG4). Biophysical characterisation confirmed that one nanobody (B11) binds with high affinity to a wide range of DNA G4 …
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The Archaeology of an Ancient Seaside Town: Performance and Community at Samanco, Nepeña Valley, Peru Volume 1
… vast food products, likely through the aid of camelid caravans, played an important part in early urban political economy and the overall success of the community. Daily interactions, seen as culturally important performances, promoted subsistence industry as a site identity. Patios at the …
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Investigating the self-assembly and molecular chaperone ability of casein proteins and polyproline
… alphas1- and beta-casein, as well as caprine and camelid beta-caseins) to form amyloid fibrils under physiologically relevant conditions was demonstrated using thioflavin T binding, transmission electron microscopy and X-ray fibre diffraction and far-UV circular dichroism. Partial digestion of …
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Investigating the self-assembly and molecular chaperone ability of casein proteins and polyproline
… alphas1- and beta-casein, as well as caprine and camelid beta-caseins) to form amyloid fibrils under physiologically relevant conditions was demonstrated using thioflavin T binding, transmission electron microscopy and X-ray fibre diffraction and far-UV circular dichroism. Partial digestion of …
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Fibre Production Among the Coastal Hunter-gatherers of South America’s West Coast: New Narratives from Plant Fibre Technologies
… were being added to fibre production, such as camelid hair and various pigments near the end of the Preceramic Period, which coincided with the appearance of more elaborate artefacts. The function of the fibre artefacts in coastal activities is also crucial for understanding the social …
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Developing nanobodies to stabilise the tumour suppressor protein p16INK4a
… devoid of light chains found in the serum of the Camelid family (camels and llamas). Despite the absence of light chains, heavy-chain antibodies have evolved to complement traditional antibodies and retain the full binding capacity seen in canonical IgG antibodies. The single variable domain, …
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Targeting the N-myc oncoprotein using nanobody technology
… as MYCN-amplified neuroblastoma. Nanobodies, camelid-derived single-domain antibodies, are a relatively new drug class. Whilst some are already in clinical trials for a wide range of diseases, these are specific for cell-surface or extracellular targets. However, their properties also make …
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Embryo Production by Superovulation and Dual Siring in Alpacas
Alpacas have a gestation length of nearly one year, and therefore females can only produce one offspring per year. In order to accelerate the genetic gain of a herd, superovulation and embryo transfer techniques can be used to produce multiple embryos from genetically superior females. We …
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Isolation and Characterization of Anti-SLP Single Domain Antibodies for the Therapy of C. difficile Infection
Clostridium difficile is the leading cause of death from gastrointestinal infections in Canada. Current antiobiotic treatment is non-ideal due to the high incidence of relapse and the rise in hyper-virulent antibiotic-resistant strains. Surface layer proteins (SLPs) cover the entire bacterial …