Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"calpastatin"”.
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Calpain inhibitor design inspired by the natural inhibitor calpastatin
… a naturally occurring and specific inhibitor, calpastatin, which binds with high affinity to the active site but in such a way that the calpastatin itself is not cleaved. Crystal structures of the full-length calpain-2 in complex with calpastatin have aided the design of novel calpain-specific …
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The role of proteases in development of cancer in mice
… fluorescent assay, differences in m-calpain and calpastatin activity were found between seven and nine month ethyl carbamate treated mice. The calpain to calpastatin ratio is higher in the nine month treated mice due to a decline in the activity of calpastatin with age. Changes in the calpain …
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Postmortem energy metabolisms' role in calpain activation, inhibition, and subsequent function
… by EGTA, cysteine protease inhibitor, and calpastatin strongly suggested the proteolysis observed in our system was indeed calpain-dependent. Second, we explored the relationship between calcium availability, calpastatin abundance, and calpain-1 autolysis in the aforementioned system. In …
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A Novel Cardiac Function of Sumo2/3 and Senp5 Dependent Pathway and Its Physiological Impact On Congestive Cardiomyopathy
… by promoting cardiac cell death. Calpain2 and Calpastatin as a novel SUMO2 targets have been known to be involved in mitochondrial-independent cell death pathway in heart. These SUMOylations of Calpain2 and Calpastatin facilitate activation of Calpain2 by reducing inhibitory role of …
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Increased structure-bound proteolytic activity in maturing dystrophic skeletal muscle
… due to the relative distribution of calpain and calpastatin, calpain's endogenous inhibitor. Calpain activity was assessed in quadriceps and diaphragm muscle homogenate supernatant and pellet fractions from C57BL/6 control and mdx mice at ages 7, 14, and 21 days. Total calpain and calpastatin …
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Interaction Between Brk and Her2 In Breast Cancer
… Brk expression via inhibiting calpain activity. Calpastatin is a calpain endogenous inhibitor and the calpain-calpastatin system has been implicated in a number of cell physiological functions. HER2 restrained calpain activation via up-regulating calpastatin expression and HER2 downstream …
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Targeting Calpain-1 and Calpain-2 for Prevention of Breast Cancer Metastasis: In Vivo Insights and Drug Discovery Approaches
… of 150 µM. I additionally designed a calpastatin-based peptide inhibitor of calpain that inhibited calpain-2 with an IC50 16.2 nM, limited calpain-dependent MDA-MB-231 cell migration to 53.5% and significantly reduced the high variance in calpain-dependent breast cancer metastasis but …
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QTL Mapping and Molecular Dissection of Meat Quality Traits in Swine
… including one within the candidate gene calpastatin (CAST), were developed. These markers, along with nine publicly-available markers, were used to perform linkage and haplotype analyses within the IMQP. Within-family linkage analyses revealed at least two families segregating for a …
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Understanding Beef Quality Development and Different Feeding Regimes
… or glycolytic proteins, or calpain-1 and calpastatin between varying phases of growth. However, based on our complementary transcriptomics data, we found linear trends in gene expression related to adipogenesis and muscle hypertrophy, implying these differences may simply be a result of …