Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"calpain inhibitors"”.
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Synthesis of Novel Sulfonamide-Based Calpain Inhibitors and Their Potential as Anti-Tumor Agents
<p>Calpain is a class of intracellular cytoplasmic cysteine proteases.1 The enzyme participates in different intracellular signaling pathways that are mediated by Ca2+.2 The two major isoforms of calpain universally distributed in most mammalian tissues are calpain 1 (µ-calpain) and calpain 2 …
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Exploring the effect of genetic calpain disruption on cell migration, invasion, drug sensitivity, and metastasis in triple negative breast cancer
… reported to promote spread to secondary sites. Calpains are a family of calcium-activated proteases that have emerged as a potential target in triple-negative breast cancer. Calpains cleave substrates involved in various cell signalling pathways associated with tumourigenesis and metastasis. …
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Design and synthesis and testing of conformationally constrained peptidomimetics.
… Chapter Three introduces cysteine protease calpain II as the primary biological target for this thesis. Calpain is implicated in cataract formation and its inhibition is a logical approach to cataract prevention. Proteases are known to, almost universally, bind substrates and inhibitors in a …
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Investigation into the lipid activation of calpain and its role in cataract formation
… is easily administered and equally effective. Calpains are Ca2+dependent intracellular proteases and several of these enzymes are believed to participate in cataractogenesis. Calpain 2 is the major isoform of calpain involved in human cataractogenesis and its activation appears to be …