Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"calpain 2"”.
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N-terminomics/proteomics investigation of Calpain-2 substrates
Calpains are a family of intracellular cysteine proteases that require calcium for activation. Calpain-1 and -2, first described as the classical calpains due to their ubiquitous expression, are part of this larger 15-member family in humans and share similar patterns of expression and structural …
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Elucidating Isoform Specific Roles of Calpain-1 and Calpain-2 in Breast Cancer
… disease. This study investigated the roles of calpain-1 and calpain-2 in metastatic breast cancer. Genetic knockout of CAPN1, CAPN2, and CAPNS1 genes allowed us to analyze the functions of these two calpain isoforms in the MDA-MB-231 triple negative breast cancer model cell line and to …
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Targeting Calpain-1 and Calpain-2 for Prevention of Breast Cancer Metastasis: In Vivo Insights and Drug Discovery Approaches
… decline in breast cancer patients’ survival. Calpain-1 and -2, ubiquitous calcium-dependent cysteine proteases, are a potential novel therapeutic target in cancer as they are upregulated in multiple cancer subtypes, including breast cancer, and have been implicated in tumor progression, …
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Investigation into the lipid activation of calpain and its role in cataract formation
… is easily administered and equally effective. Calpains are Ca2+dependent intracellular proteases and several of these enzymes are believed to participate in cataractogenesis. Calpain 2 is the major isoform of calpain involved in human cataractogenesis and its activation appears to be …
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Effects of four weeks of daily soy or dairy milk ingestion on the exercise-induced proteolytic responses in plasma and skeletal muscle in a post-menopausal female population.
… decade of life. Evidence indicates that the calpain and ubiquitin proteolytic degradation pathways account for the majority of myofibrillar protein degradation seen with muscle atrophy. The purpose of this study was to investigate the effects of daily consumption of soy or dairy milk in older …
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Calpain inhibitor design inspired by the natural inhibitor calpastatin
Calpains are cysteine proteases that depend on Ca2+ for activation. They have many roles in the cell; hence modifications of calpains or changes in their levels of activity can lead to altered physiological states. Thus, it is of great interest and medical relevance to design inhibitors that can …
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Increased Mitochondrial Calpain-1 Is an Important Mechanism Contributing to Mitochondrial ROS Generation in Cardiac Diseases
Both calpain activation and excessive mitochondrial reactive oxygen species (mtROS) have been implicated in the pathogenesis of cardiac diseases. We investigated whether and how calpain regulates mtROS generation in mediating cardiac diseases. In mouse models of streptozotocin-induced type-1 …
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Effects of 28 days of protein and amino acid supplementation and ankle immobilization on gastrocnemius muscle mass and strength and atrophy- and apoptosis-related gene expression in males.
… 20S-HC2, 20S-HC3, E2, E3, atrogin-1, MuRF1, calpain 1, calpain 2, myostatin, TNF-α, and NF-κB. Results: Lower-leg girth decreased over time (p = 0.020), and increased the expression of several genetic variables, but there were no significant changes in the body composition or strength …
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Synthesis of Novel Sulfonamide-Based Calpain Inhibitors and Their Potential as Anti-Tumor Agents
<p>Calpain is a class of intracellular cytoplasmic cysteine proteases.1 The enzyme participates in different intracellular signaling pathways that are mediated by Ca2+.2 The two major isoforms of calpain universally distributed in most mammalian tissues are calpain 1 (µ-calpain) and calpain 2 …
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Protein Utilization and Requirements in Broiler Breeders
… to be elevated. No changes to the proteasome and calpain 2 were observed that would explain changes to degradation rates. In the final two studies, the effects of low non-phytate phosphorus (NPP) on the diurnal patterns of bone turnover and the effects of carnitine supplementation on the fatty …
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Determining the mechanism of pulsed electric field for improving meat quality : A thesis submitted in partial fulfilment of the requirements for the Degree of Doctor of Philosophy at Lincoln University
… of calcium ions and early activation of the calpain proteases. However, experimental research is yet to confirm this postulation. The changes in the calpain activity and protein profile of beef from older animals during ageing is poorly explored and further understanding of biochemical …
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A Novel Cardiac Function of Sumo2/3 and Senp5 Dependent Pathway and Its Physiological Impact On Congestive Cardiomyopathy
… hypertrophy by promoting cardiac cell death. Calpain2 and Calpastatin as a novel SUMO2 targets have been known to be involved in mitochondrial-independent cell death pathway in heart. These SUMOylations of Calpain2 and Calpastatin facilitate activation of Calpain2 by reducing inhibitory role …