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Showing 1 to 20 of 22 for “"calixarenes"”.
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A New Approach to Drug Delivery: Non- Peptidic, High Load Macrocyclic Alternatives to Cell Penetrating Peptides
Calixarenes are versatile macrocycles formed from the condensation of para-tertbutyl- phenol and formaldehyde. Chapter 1 describes the synthesis of these molecules and how conformational control and selective functionalisation can give an array of molecules with customised properties; this allows …
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Research towards novel immunotherapeutic vectors: calixarene scaffolds
… delivery system and immunogenic vector, based on calixarenes, that is able to not only deliver immunogenic peptide but also act as a potential cancer vaccine. The introduction presents calixarenes derivatives in the context of supramolecular chemistry. Their properties on the nanoscale allow them …
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Synthesis of Tin Containing Calix[4]arenes and their Anion Binding Capabilities
… research has been done on the ability of calixarenes to complex cations and neutral species. The electron-rich molecular cavity and lower rim consisting of a cyclic array of oxygen donors makes the structure of the calixarene conducive to this type of complexation. Conversely, the …
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Calixarene Linked Bis-Porphyrin Hosts for Fullerenes and the Assembly of Supramolecular Ferrocene-Porphyrin-Fullerene Triads
… These porphyrins have been coupled to calixarenes to construct bis-porphyrin hosts. UV-visible complexation studies and co-crystallates of porphyrins with fullerene have revealed that the 15-position of the porphyrin exhibits a greater influence of the fullerene affinity than initially …
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SYNTHESIS AND CHARACTERIATION OF WATER SOLUBLE C2 AND C3 SYMMETRIC MULTI-CALIX[4]ARENE DENDRIMERS AND PILLARARENES A NOVEL CLASS OF MACROCYCLE IN SUPRAMOLECULAR CHEMISTRY
… through the use of pillararenes and calixarenes coupled to porphyrins; in particular it was designed to the preparation of discrete assembled at the nanoscopic level, by means of hierarchical 'self-assembly' of organized systems governed by electrostatic interactions and host-guest …
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Synthesis of Novel Calix[4]arene Based Dendrimers and their Biological Applications
… describes the development and synthesis of multicalixarenes and their application in gene and drug delivery. Chapter 1 provides an introduction to gene therapy and calixarenes. The synthesis of two families of amino functionalised multicalixarenes are described. Evaluation of their toxicity and …
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Calixarene and coordination complex hosts for anions.
… based on derivatives of larger calix[n]arenes. Calixarenes are chalice-shaped molecules that form readily under base catalyzed-condensation of tert-butyl phenol with formaldehyde. We have synthesized calixarenes which were tuned at the lower rim with bromo alkyl nitrile and reduced followed by …
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Structural supramolecular constructs of spheres and tubes
… and how they interact with the cup shaped calixarenes. With the small addition of C70 that is comparable to that found in the native fullerite, the crystal structure of the resulting complex is radically changed from pure C60 and calix[5]arene. C70 with calix[5]arene was also revealed …
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Synthetic and structural studies of Calix[4]pyrogallolarenes: towards biological applications
… investigation of cellular toxicity of the calixarenes has also been performed and indicates that this class of molecules does not appear to possess a high degree of toxicity towards dendritic cells and peripheral blood mononuclear cells which are the envisioned target of this delivery …
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Stereo-Selective Synthesis of Bis-bridged calix[6]arenes
… the substrate and metal ion to form a complex. Calixarenes have certain structural features analogous to enzymes, which include a well-defined cavity for host-guest complex interactions, and potential for structural variation. Research conducted in the Blanda group has focused on the synthesis …
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Synthesis and cation binding properties of bis-bridged calix[6]arenes
Calixarenes have been studied and utilized for their molecular recognition properties. A total of four bis-bridged calix[6]arenes have been synthesized and their metal binding properties and structural conformations were studied in solid, solution, and gas phase. Methods of testing include: NMR …
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Conformationally Immobile Calix[6]arenes as Negative Resists in Electron Beam Lithography
… features. Literature reports that calixarenes have the potential to meet this challenge, due to their ultrahigh resolution and their process robustness. For this study, the “1,2,3-alternate” and “cone” conformers of Diallyloxy-Bis-/77-Xylenyloxycalix[6]arene were synthesized via a …
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Nano chemistry : large molecular capsules and coordination networks based on self-assembly
… recognition and the history and synthesis of calixarenes. The supramolecular chemistry of the p-sulfonatocalx[n]tilarenes and a selection of interesting and recently reported nano-metre scale multi-component supramolecular architectures are also reviewed. Chapter 2 describes the pH dependent …
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An Investigation of the destruction of ion exchange resins
… beads and model systems such as water soluble calixarenes. 2) Use of various physical and chemical techniques in an attempt to improve the overall efficiency of hydrogen peroxide utilization. Examples of these techniques include UV irradiation, both with and without a photocatalyst, oxygen …
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Molecule recognition of nucleic acids, nucleosides, nucleotides, and their derivatives
… towards cancer cells was also investigated. Calixarenes containing DNA building units such as nucleotides, nucleosides, and nucleobases have recently aroused much interest because of their versatile applications. In chapter 5, we report the synthesis of calix[4]arenes ( 5.11-5.14 ) …
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Synthesis of Higher Homologues of Cucurbituril Derivatives and Evaluation of their Supramolecular Properties
… such as crown ethers, cyclodextrins and calixarenes, its further development has been limited by the challenge of achieving its functionalisation. The introduction of substituents, especially those carrying reactive functional groups, into Q[n] has met with significant problems, such as …
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Factors Influencing the Stereochemistry in Bis-bridging Reactions of calix[6]arenes
No abstract prepared.
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Photoresponsive nanosystems for therapeutic applications
Oncological and bacterial diseases are certainly the most troubling illnesses of the twenty-first century, and the data in this regard are staggering. Indeed, anticancer chemotherapy is affected by low specificity/selectivity and undesired side effects, and drug resistance phenomena are responsible …
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