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Showing 1 to 20 of 32 for “"calcium uptake"”.
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Effects of Temperature on Calcium Uptake in BOSSIELLA ORBIGNIANA ORBIGNIANA
… Silva, 1957] (Corallinaceae) was studied using calcium-45 labeling of terminal segments under laboratory conditions. <em>B. orbigniana</em> has optimum calcium uptake for the temperatures 17-21°C within a temperature range of 3-37°C. These results suggest that optimum calcification in <em>B. …
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Mitochondrial Calcium Uptake: LETM1 and MICU1 Are Mitochondrial Proteins That Regulate Mitochondrial Calcium Homeostasis and Cellular Bioenergetics
Mitochondrial calcium (Ca2+) uptake has been studied for over five decades, with crucial insights into its underlying mechanisms enabled by development of the chemi-osmotic hypothesis and appreciation of the considerable voltage present across the inner mitochondrial membrane (ΔΨm) generated by …
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Signal transduction events in human NK cells: role of PKC and calcium uptake in activated and inactivated NK cells
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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The effects of fatigue on glycogen, glycogen phosphorylase, and calcium uptake associated with the sarcoplasmic reticulum of rat skeletal muscle
… regulation of force production. The release of calcium (Ca²⁺) from the sarcoplasmic reticulum (SR), which is stimulated by the depolarization of the sarcolemma, causes muscle contraction. The SR Ca²⁺-adenosine triphosphatase (ATPase) drives the translocation of two Ca²⁺ ions into the SR, …
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Sarcoplasmic reticulum responses to repeated sprints, conditioning and dietary lecithin in the horse
… reticulum (SR) releases and sequesters calcium during muscle contraction and relaxation. Calcium uptake rates have been shown to respond to high intensity exercise, and we propose this response may be affected by conditioning and dietary lecithin. Ten Quarter Horses performed repeated …
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Effect of Alpha-Amylase Treatment and Exercise on the Calcium Handling of the Sarcoplasmic Reticulum
… This complex is suspected to participate in the calcium uptake activities of the sarcoplasmic reticulum (SR). Removal of glycogen particles associated with this complex may alter the calcium handling abilities of the SR. This experiment sought to determine what effect exercise and treatment with …
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Mitochondrial response to axonal injury
… LC3. In vitro models revealed that mitochondrial calcium uptake is necessary for injury induced mitochondrial fission, as inhibiting mitochondrial calcium uptake using RU360, a mitochondrial calcium uniporter inhibitor, prevented injury induced fission. This phenomenon was also observed in vivo. …
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Role of the Vitamin D Receptor in Insulin Secretion and Beta Cell Function
… major islet hormones, nor does it change glucose uptake into primary beta cells. VitD does however increase glucose-stimulated calcium uptake, suggesting that VitD affects transcription of genes involved in calcium flux into the beta cell. To identify molecular mechanisms linking VDR activity to …
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Pattern and Mechanism of Calcium Mobilization During Embryonic Development in a Viviparous Snake, <em>Virginia striatula</em>.
<p>Yolk supplies the majority of embryonic calcium in snakes. Oviparous and viviparous snakes also receive calcium late in development from the eggshell and placenta, respectively. The pattern and mechanism of calcium transport are partly understood for oviparous snakes. I studied a viviparous …
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The Role of Pkd1 in Mouse Inner Ear Hair Cells
… based on PC-1 role of fluid flow sensing and calcium uptake into renal epithelial cells. However, two independent mouse lines with PC-1 mutations exhibit normal MET channel function despite hearing loss and ultra-structural abnormalities of stereocilia that remain properly polarized at adult …
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Manganese-enhanced magnetic resonance imaging in cardiometabolic disorders
… Dysregulated myocardial and pancreatic beta-cell calcium handling may be a key mediator and driver of these disorders. Manganese is a calcium analogue which has paramagnetic properties. Cellular uptake of manganese by voltage gated L-type calcium channels causes T1 shortening and intracellular …
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Spatio-Temporal Calcium Dynamics of the Interstitial Cells of Cajal
… in turn linked to the integrated transport of calcium between the endoplasmic reticulum (ER), through inositol-trisphosphate receptor (IP3R) release, and mitochondria, through the uniporter. In the intestinal regions, a non-specific cation channel (NSCC) is associated with the membrane …
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Magnetothermal Modulation of Nerve Growth
… that are a critical target for nerve therapy. Calcium influx into neurons plays a key role in many processes necessary for axonal regeneratiton. Using magnetothermal modulation, we stimulate calcium uptake into DRG cells via TRPV1 ion channels, which are endogenously expressed and heat …
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Changes in Skeletal Muscle Sarcoplasmic Reticulum Calcium Handling and Regulatory Protein Content in Congestive Heart Failure
… for the fatigue. During skeletal muscle fatigue, calcium handling is altered. Thus, the fatigue associated with congestive heart failure could be attributed to altered calcium handling. The main proteins involved in calcium release are the ryanodine receptor (RyR) and the dihydropyridine receptor …
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Investigation of the endoplsmic reticulum calcium stores for their potential roles in neuroprotection using the NG115-401L neuronal cell line model
… the neuronal cell line NG115-401L with unique calcium signaling characteristics to test the hypothesis that improving calcium loading into the endoplasmic reticulum (ER) to increase ER calcium levels acts as a possible neuroprotective response. We approached this problem using both …
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Investigation of the proteomic interaction profile of uncoupling protein 3 and its effect on epigenetics
… reactive oxygen species (ROS) scavenging and calcium uptake. And several proteins have been identified to directly bind with UCP3 and facilitate its function. But to further understand how UCP3 relates to different aspects of mitochondrial functions, a more comprehensive profile of the UCP3 …
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Calcium-dependent mechanisms in the chicken retina
… this study, I show that inhibiting mitochondrial calcium uptake (MCU) caused a reversible reduction in the Ca2+ current amplitude. Replacing external Ca2+ with Ba2+ minimized the effects of blocking MCU indicating that the Ca2+ influx is the primary source of the inhibition. With …
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Functional characterization of a putative Plasmodium falciparum calcium/hydrogen antiporter pfcha
… of essential genes are needed. Although the calcium metabolism is very important in the life of P. falciparum, little is known about the genes which regulate the transport of calcium. With the release of the P. falciparum genome, a putative calcium hydrogen antiporter has been identified. To …
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Activity-dependent mitochondrial signaling drives GLR-1 dynamics and behavioral sensitization in C. elegans
… of neuronal activity as well as subsequent calcium influx and its downstream signaling on synaptic AMPAR localization. However, how subcellular compartments, such as mitochondria, contribute to localized signaling, and how they affect AMPAR transport and delivery dynamics are still unknown. …
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The Signaling Pathway of Oxysterol Induced Apoptosis in Chinese Hamster Ovary (CHO)-K1 Cells.
… that vascular cells undergo apoptosis after uptake of oxidized low-density lipoprotein (oxLDL). Thus, an analysis of the signaling pathway of apoptotic induction by oxLDL is of value in understanding the development of atherosclerotic plaque. In order to elucidate the signaling pathway of …
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