Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"calcium sensitivity"”.
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Effects of progressive resistance training on single myofiber calcium sensitivity in older women
… training program (PRT) on single myofiber calcium sensitivity in older women. Five healthy older women between the ages of 67-82 with a mean age of 72.8±2.7 yr. participated in this study. The training regimen consisted of bilateral isotonic knee extensions. The subjects performed 3 sets, …
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Effects of Actin-Myosin Kinetics on the Calcium Sensitivity of Regulated Thin Filaments
… myosin binding sites on actin either through calcium-troponin binding or by actin-myosin (AM) strong binding. However, the extent to which each of these binding events contributes to thin filament activation remains unclear. Here we propose a simple analytical model in which strong AM binding …
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Calcium sensitivity of neurotransmitter release in a glutamatergic synapse of the central nervous system
Der Signalübertragung an chemischen Synapsen liegt ein Kopplungsmechanismus zwischen dem präsynaptischen Aktionspotential und der biochemischen Überträgerstoff-Ausschüttung zu Grunde. Dabei werden Ca2+-Kanäle geöffnet und ein Freisetzungssensor Ca2+-abhängig aktiviert, der schließlich die …
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Postnatal Maturation Modulates Cerebrovascular Myogenic Tone
… maturation decreases contractile reliance on calcium influx and myofilament Ca2+ sensitivity, and increases reliance on release of calcium from intracellular stores to develop and maintain pressure-evoked myogenic tone in rat cerebral blood vessels. To test this hypothesis, pressure-induced …
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Mechanisms underlying the development of weakness in idiopathic inflammatory myopathies: an in vitro single muscle fibre contractility study
… output were assessed in some of the fibres, and calcium sensitivity in the rest. The myosin heavy chain composition of each fibre was determined by means of gel electrophoresis. Results: A total of 178 fibres from IIM cases and 174 fibres from controls were studied. Specific (normalised) force …
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Developmental regulation of smooth muscle contraction in the urinary bladder
… subtype in both adults and newborns. Activator calcium is mainly recruited from the extracellular space via L-type calcium channels in both adult and newborn tissue. The contractile machinery of the newborn’s bladder tissue is more sensitive to calcium which enables contractions at lower …
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Calciumkanaldichte in humanem ischämischen und reperfundierten, rechtsatrialen Myokardgewebe
Intracellular calcium overload is one of the major pathophysiological mechanisms contributing to myocardial ischemic injury. Two important calcium handling proteins responsible for the maintenance of an intracellular calcium homeostasis are the sarcolemmal voltage-gated L-type calcium channel …
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Thermodynamic effects of phospholamban on Ca-ATPase kinetics
… of sarcoplasmic reticulum removes cytosolic calcium to promote muscle relaxation. In the heart, the Ca-ATPase is regulated by phospholamban, which inhibits the Ca-ATPase by decreasing Ca-ATPase calcium sensitivity. However, the kinetic and thermodynamic mechanisms of inhibition are not …
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Structural and functional characterization of signaling protein complexes
… 804-816). Calmodulin is a protein that confers calcium sensitivity when bound to its substrates. All voltage-gated sodium channels possess the IQ motif for binding to calmodulin but are each differently regulated. Through biophysical and computational analyses, the mode of calmodulin binding to …
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Calcium Regulation of a Slow AHP in Hippocampal Pyramidal Cells
… (sAHP) in CA1 hippocampal pyramidal cells is calcium-dependent and involves activation of KCa3.1 and KCNQ potassium channels. Both KCa3.1 and KCNQ channels bind calmodulin (CaM) as a calcium sensor, with an additional role proposed for the protein hippocalcin. We measured the calcium …
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Wirkung von milder Hypothermie auf den negativ inotropen Effekt von Halothan, Isofluran und Sevofluran auf ventrikuläres Kaninchen-Myokard
… response to the raise of extracellular calcium concentrations and the first contraction after a time interval without stimulation, each at 31°C, 34°C, 37°C and 40°C. The specimen were trabeculae and papillary muscles from the right ventricle of New Zealand white rabbits. After reaching …
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The Role of FGF Signaling in the Regulation of Adult Murine Cardiomyocyte Contractility and Pathologic Hypertrophy
… Induction of caFGFR1 appears to increase the calcium sensitivity and decrease relaxation of the sarcomere through dephosphorylation of troponin I, and also by potentially increasing cytosolic calcium, mechanisms implicated in classic HCM models. Our doxycycline-inducible cardiomyocyte-specific …
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Exocytosis in Type 2 Diabetes- Functional and genetic studies of hormone secretion
… that successfully predict reduced exocytosis, calcium-sensitivity, granular docking and GSIS. Finally, in paper V, knock-down of rno-microRNA-335 in insulin-secreting cells was found to increase Stxbp1 expression which correlates with increased exocytosis. Within the scope of this thesis we …
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The formulation, testing and stability of 16% fat cream liqueurs
… from different sources varied in their calcium sensitivity. When incorporated into cream liqueurs, caseinates influenced the rate of viscosity increase, coalescence and, possibly, gelation during incubated storage. Mild heat and alcohol treatment modified the properties of caseinate used …
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Molecular Mechanisms Underlying Alcohol-Induced Cerebral Artery Smooth Muscle BK Channel Inhibition and Eventual Cerebral Vasoconstriction
… result from the activity of large conductance, calcium-and voltage-gated potassium (BK) channels. Indeed, ethanol (50 mM) decreases the steady-state activity (NPo) of vascular myocyte BK channels leading to an increase in cerebral artery tone. In native tissues, functional BK channels are …
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Einfluss von Proteinkinase A auf isometrische Kraftentwicklung und Calciumsensitivität : eine Untersuchung am gehäuteten Herzmuskelpräparat des insuffizienten menschlichen Herzens
… kann, lassen sich Aussagen über die direkte calciumabhängige Kraftentwicklung treffen. <br> <br>Phosphorylierung der kontraktilen Proteine gehäuteter Muskelpräparate terminal insuffizienter Herzen mittels zyklischer AMP-abhhängiger Proteinkinase A führt zu einer …