Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"calcium regulation"”.
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Probing cardiac calcium regulation using time-resolved optical spectroscopy.
Sarcoplasmic reticulum calcium adenosine triphosphatase (SERCA) is an integral membrane Ca2+ pump that reuptakes Ca2+ into the lumen of sarcoplasmic reticulum (SR), decreases the cytoplasmic Ca2+ concentration, and initiates relaxation in both skeletal and cardiac muscle. In the heart, SERCA …
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Calcium Regulation of a Slow AHP in Hippocampal Pyramidal Cells
… (sAHP) in CA1 hippocampal pyramidal cells is calcium-dependent and involves activation of KCa3.1 and KCNQ potassium channels. Both KCa3.1 and KCNQ channels bind calmodulin (CaM) as a calcium sensor, with an additional role proposed for the protein hippocalcin. We measured the calcium …
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Intracellular Calcium Regulation and Changes in Ph in Molluscan Neurons
Made available in DSpace on 2014-12-14T05:40:44Z (GMT). No. of bitstreams: 1 8004119.pdf: 5835408 bytes, checksum: 900a3479f890eb5c5de309193cfc4784 (MD5) Previous issue date: 1979
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Functional Effects of Calcium Regulation of Thin Filaments at Single Particle Resolution
… (Tm), and F-actin. It provides Ca2+-dependent regulation of contraction by modulating myosin attachment and force generation in a cooperative scheme. However, this mechanism remains unclear. To understand thin filament activation, we studied the binding and functional properties of Tn and Tm to …
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Neuronal Calcium Regulation and Cellular Stress in a Malignant Hyperthermia Disease Model
<p>Calcium ions (Ca2+) are essential signaling molecules and must be carefully regulated to preserve specificity in function. One indispensible Ca2+ signaling protein is the ryanodine receptor (RyR) calcium release channel. RyR1 is essential for muscle contraction, and RyR1mutations can lead to …
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Effects of altered physical activity on human skeletal muscle sarcoplasmic reticulum calcium regulation
… reticulum (SR) regulates intracellular calcium and therefore largely determines the rates of contraction and relaxation in skeletal muscle. However, little is known about SR function in human skeletal muscle. This thesis therefore investigated several factors that could potentially …
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Effects of Advancing Age on ER Calcium Regulation in Rat Superior Cervical Ganglia
<p>Intracellular calcium ([Ca<sup>2+</sup>]i) release from endoplasmic reticulum (ER) stores plays an important role in cell signaling. These stores are rapidly refilled via voltage-gated calcium channels or spontaneously via store-operated calcium channels and subsequent pumping by ER …
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Effects of calcium and other ions on fast axoplasmic transport and their relationship to calcium regulation
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Impaired metabolism in X-linked muscular dystrophy: experimental evaluation of potential therapies to improve calcium regulation, bioenergetics and muscle architecture
… protein (WP), in improving intracellular Ca2+ regulation, energy and protein balance and tissue architecture, thus alleviating a degree of the dystrophic pathology. 1. Whether the ATP-producing capacity of dystrophic mitochondria is defective remains largely contentious, and no study to date …
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Lens calcium homeostasis and selenite cataract
… mechanism of selenite cataractogenesis involves calcium activation of calpain with subsequent proteolysis within the lens nucleus. This study was undertaken to investigate the biochemical mechanisms that lead to calcium accumulation in these circumstances. The components responsible for rat lens …
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Calcium homeostasis in Escherichia coli
<p>While the role of calcium ions as secondary chemical messengers has been well described in eukaryotic cells, little is known about calcium homeostasis in bacteria at the physiological and molecular level. No calcium influx gene has been identified so far. This dissertation focuses on calcium …
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Functional characterisation of the human mitochondrial ATP-Mg/Pi carriers and their disease-causing variants
… inner membrane, which is regulated by calcium. They are responsible for modulating the adenine nucleotide pool in the mitochondrial matrix, and therefore have a pivotal role in meeting the energetic demands of the cell. They consist of three domains; an EF hand-containing regulatory …
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CatSper: Characterisation in Human Spermatozoa and Clinical Significance
… in particular sperm motility. The sperm-specific calciumpermeable cation channel CatSper is necessary for initiation of hyperactive motility in murine spermatozoa, and was previously identified to be disrupted in sperm from an infertile patient. However, little is known about the incidence of …
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Role of SLMAP in Endoplasmic Reticulum Stress and Unfolded Protein Response
… in homeostatic balance of these proteins and calcium regulation results in activation of ER stress response. Sarcolemmal membrane-associated proteins (SLMAPs) are found in cell membrane, SR/ER, and mitochondria. Overexpression of SLMAP in the myocardium has shown to impair …
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Flower Isoforms Increase Expression in Response to Cellular Stress and Modulate S100 Expression in Cutaneous Squamous Cell Carcinoma Cells
… differentiation of the skin is regulated through calcium-associated signaling. Better understanding the role of calcium regulation in the epidermis and its relation to the progression of skin cancer could be important in finding new interventions. Protein isoforms called hFWE3 and hFWE4 have been …
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THE EFFECTS OF TRICHLOROETHYLENE ON HEART DEVELOPMENT
… and animal models. Recent data suggest misregulation of Ca2+ homeostasis in a cardiomyocyte cell line after TCE exposure (Caldwell, Thorne et al. 2008). We hypothesized that misregulation of Ca2+ homeostasis alters myocyte function and leads to changes in embryonic blood flow. In turn, …
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Investigation of the endoplsmic reticulum calcium stores for their potential roles in neuroprotection using the NG115-401L neuronal cell line model
… the neuronal cell line NG115-401L with unique calcium signaling characteristics to test the hypothesis that improving calcium loading into the endoplasmic reticulum (ER) to increase ER calcium levels acts as a possible neuroprotective response. We approached this problem using both …
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Presenilins Modulate Cellular Activity of Ryanodine Receptors
… large, endoplasmic reticulum (ER) intracellular calcium channels in excitable cells. RyRs are major cellular mediators of calcium-induced calcium release and crucial regulators of intracellular calcium homeostasis. Disruption of RyR function has been described in pathologies of dysregulated …
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Retroviral envelope glycoproteins: mediators of neuropathology in nervous system development and neurodegeneration in HIV-1 infection
… and observing its effect on morphology and calcium regulation. The oligopeptide produced changes manifested as altered morphology, loss of motility, and increased [Ca2+]i. This suggests a mechanism by which FeLV in particular and retroviruses in general might contribute to abnormal nervous …
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A Calcium-Centered Socio-Ecological Model of Prostate Cancer Disparities: Preliminary Studies and Findings
… interactions involving the different levels of calcium regulation. Using a multi-method design, this research aims at developing an integrative mechanistic model of PCa. We argue that given the versatile and ubiquitous role calcium plays in nutrition, physical environment, and in key cellular …
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