Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 55 for “"calcium homeostasis"”.
-
Calcium homeostasis in Pichia pastoris
… In this study, we examined the effects of calcium and magnesium on growth, heterologous protein expression, and calcium homeostasis in P. pastoris . The divalent cations calcium and magnesium are responsible for diverse roles in in the function of the cells in eukaryotes. Although it is …
-
Calcium homeostasis in Escherichia coli
<p>While the role of calcium ions as secondary chemical messengers has been well described in eukaryotic cells, little is known about calcium homeostasis in bacteria at the physiological and molecular level. No calcium influx gene has been identified so far. This dissertation focuses on calcium …
-
Natural Genetic Variation Affecting Calcium Homeostasis
<p>Calcium (Ca) is essential for multiple functions within the body including skeletal health. The level of Ca in the serum is tightly regulated. During periods of habitual low Ca intake, the body senses a decrease in serum Ca and increases renal conversion of 25 hydroxyvitamin D (25(OH)D) to 1,25 …
-
Lens calcium homeostasis and selenite cataract
… mechanism of selenite cataractogenesis involves calcium activation of calpain with subsequent proteolysis within the lens nucleus. This study was undertaken to investigate the biochemical mechanisms that lead to calcium accumulation in these circumstances. The components responsible for rat lens …
-
Effects of Cadmium on Calcium homeostasis and physiological conditions of the freshwater Mussel Anodonta anatina
… of depuration. Furthermore, the effects of Cd on calcium (Ca) homeostasis, condition index, energy reserves, carbonic anhydrase activity and their correlations were examined and evaluated. Before mussels were exposed to Cd, a Cd-exposure experiment with the green algae Parachlorella kessleri was …
-
Mitochondrial Calcium Uptake: LETM1 and MICU1 Are Mitochondrial Proteins That Regulate Mitochondrial Calcium Homeostasis and Cellular Bioenergetics
Mitochondrial calcium (Ca2+) uptake has been studied for over five decades, with crucial insights into its underlying mechanisms enabled by development of the chemi-osmotic hypothesis and appreciation of the considerable voltage present across the inner mitochondrial membrane (ΔΨm) generated by …
-
New Insights Regarding the Intracellular Effects, Trafficking, and Quality Control of the Amyloid Precursor Protein: Implications for Alzheimer’s Disease Pathogenesis
… also evidence that disruption of intracellular calcium homeostasis contributes to AD pathogenesis, especially in cases of FAD related to PSEN mutations. However, important questions remain unanswered regarding the pathogenesis of AD, and thus, research has increasingly focused on identifying new …
-
The Role of Hormones and Ions in the Physiological Control of Cellular Proliferation in Rat Erythropoietic and Lymphopoietic Tissues
… are precisely regulated by modulations of the calcium homeostatic system. In this context, other hormones are demonstrated to interact with those controlling calcium homeostasis. Erythropoietin and the antidiuretic hormone have been studied in depth and are shown to be co-ordinated with the …
-
Association between plasma 25-hydroxyvitamin d concentrations and salivary cytokines in postmenopausal women
… its immune modulatory mechanisms and its role in calcium homeostasis. Few studies have investigated the association of vitamin D status and biomarkers of oral inflammation. Our objective was to examine the cross-sectional association between vitamin D status and measures of four salivary cytokines …
-
Nitric oxide influences muscle physiology and meat quality
… of muscle contractility, energy metabolism, calcium homeostasis, and proteolysis have emerged. Since many of these processes are critical determinants of meat quality, the hypothesis of this thesis is that NO influences physiological determinants of meat quality.
-
Trpv5: Structure, Function And Drug Discovery
… vanilloid 5 (TRPV5) channel is a highly calcium selective ion channel that regulates systemic calcium homeostasis by acting as a critical gate for calcium reabsorption in the kidney. Human polymorphisms of this channel have exemplified the importance of TRPV5 in disorders of calcium …
-
PKCε and cardioprotection : an exploration of putative mechanisms
… proteins, which orchestrate mitochondrial homeostasis, including proteins governing mitochondrial oxidative phosphorylation, electron transfer, ion transport and control of mitochondrial permeability transition (MPT). MPT disruption is regarded as a key step in the initiation of an …
-
Presenilins Modulate Cellular Activity of Ryanodine Receptors
… large, endoplasmic reticulum (ER) intracellular calcium channels in excitable cells. RyRs are major cellular mediators of calcium-induced calcium release and crucial regulators of intracellular calcium homeostasis. Disruption of RyR function has been described in pathologies of dysregulated …
-
Antioxidant Intervention With manganese(Iii)-Salophen in the Selenite Cataract Model: Implications for Cataract Disease
… proteolysis of lens crystallins and loss of calcium homeostasis occur in cataractous lenses from a rat treated with sodium selenite. The visual protection with Mn(III)-salophen is accompanied by a partial loss of the calcium homeostasis, a net increase in sodium, and calpain-mediated …
-
Calciumkanaldichte in humanem ischämischen und reperfundierten, rechtsatrialen Myokardgewebe
Intracellular calcium overload is one of the major pathophysiological mechanisms contributing to myocardial ischemic injury. Two important calcium handling proteins responsible for the maintenance of an intracellular calcium homeostasis are the sarcolemmal voltage-gated L-type calcium channel …
-
Effect of a Low-Carbohydrate, High-Protein Diet on Bone Mineral Density, Biomarkers of Bone Turnover, and Calcium Metabolism in Healthy Pre-Menopausal Females
… bone turnover, indicators of acid-base balance, calcium homeostasis and fasting lipids in healthy pre-menopausal women was conducted. Women, aged 32 - 45 y, with a body mass index between 25-41 kg/m2 were randomized into one of two diet groups: LCHP (n = 13) or high-carbohydrate, low-fat (HCLF) …
-
Mitochondrial Contributions to Schizophrenia Symptom Severity: A GWAS Approach in a South African Population
… from specific failures in ATP production and calcium homeostasis, where the nuclear background determines the pathogenicity of mitochondrial variants.
Page 1 of 3