Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 34 for “"calcium handling"”.
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Discovery and Characterization of Genes Involved in Muscle Calcium Handling
Muscle tissue requires continuous cycling of calcium release and clearance to generate and sustain contraction. When the plasma membrane of a muscle fiber becomes electrically excited, a voltage sensor in the membrane, called the dihydropyridine receptor (DHPR), becomes activated and signals to the …
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Age-associated changes to calcium handling proteins across the whole heart
… such problems is the regulation of intracellular calcium ions (Ca²⁺) which is involved in contraction of the heart and the upstroke of the sinoatrial (SA) node pacemaker. Dysfunction in the regulation of intracellular Ca²⁺ increases the probability of an arrhythmogenic episode and would be …
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Sarcoplasmic Reticulum Calcium Handling in Maturing Skeletal Muscle From Two Models of Dystrophic Mice
… still unclear. One possibility is that disrupted calcium (Ca²⁺) handling by the sarcoplasmic reticulum (SR) leads to an increased cytosolic Ca²⁺ concentration that activates proteolytic and apoptotic pathways that initiate muscle fiber death. However, little is known about the role of disrupted SR …
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Effect of Alpha-Amylase Treatment and Exercise on the Calcium Handling of the Sarcoplasmic Reticulum
… This complex is suspected to participate in the calcium uptake activities of the sarcoplasmic reticulum (SR). Removal of glycogen particles associated with this complex may alter the calcium handling abilities of the SR. This experiment sought to determine what effect exercise and treatment with …
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Changes in Skeletal Muscle Sarcoplasmic Reticulum Calcium Handling and Regulatory Protein Content in Congestive Heart Failure
… for the fatigue. During skeletal muscle fatigue, calcium handling is altered. Thus, the fatigue associated with congestive heart failure could be attributed to altered calcium handling. The main proteins involved in calcium release are the ryanodine receptor (RyR) and the dihydropyridine receptor …
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The Ultrastructural and Abnormal Calcium Handling in Pulmonary Vein Sleeve Cells, Atrial and Ventricular Myocytes During Ageing
… remodelling and abnormal Ca<sup>2+</sup> handling in PVCs and atrial myocytes. Whilst structural changes and alterations in the Ca<sup>2+</sup> homeostasis have been described previously in atrial myocytes, similar studies are still lacking in PVCs. Thus, this thesis investigated …
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The effects of Tumour necrosis factor-alpha and Interleukin-1-beta on intracellular calcium handling and contractility in sheep ventricular myocytes
… (2013), demonstrate that perturbed intracellular calcium handling and contractility can account for many aspects of myocardial depression. However, many of these studies suffer important limitations in that (A) small mammal models were used in which the translational relevance is questionable and …
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Manganese-enhanced magnetic resonance imaging in cardiometabolic disorders
… Dysregulated myocardial and pancreatic beta-cell calcium handling may be a key mediator and driver of these disorders. Manganese is a calcium analogue which has paramagnetic properties. Cellular uptake of manganese by voltage gated L-type calcium channels causes T1 shortening and intracellular …
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Immune Response Markers are Prevalent in the mRNA Expression Profile of Maturing Dystrophic Murine Skeletal Muscle
… for analysis were (1) disrupted expression of calcium handling proteins; and, (2) increased expression of immune response markers. An mRNA expression profile was developed following isolation of total RNA from control and mdx:utrn-/- triceps surae (TS) muscles at ages 9-10 and 20-21 days using …
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Differentiation and contractility of colon smooth muscle under normal and diabetic conditions
… was associated with an attenuated intracellular calcium increase, as measured by ratio-metric imaging of Fura-2 fluorescence in isolated colonic smooth muscle strips. This attenuated calcium increase resulted in decreased myosin light chain phosphorylation, thus explaining the decreased …
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Activity-dependent mitochondrial signaling drives GLR-1 dynamics and behavioral sensitization in C. elegans
… of neuronal activity as well as subsequent calcium influx and its downstream signaling on synaptic AMPAR localization. However, how subcellular compartments, such as mitochondria, contribute to localized signaling, and how they affect AMPAR transport and delivery dynamics are still unknown. …
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Clinical and Molecular Overview of Hypertrophic Cardiomyopathy through JPH-2 Mutations and Presentation in Clinical Case Study
… regions. One particular mutation affecting calcium handling in the sarcoplasmic reticulum, JPH-2, manifests as a possible mechanism for the onset of sudden death and histological features consistent with myocardial disarray. This thesis aims to understand junctional complex gene's, JPH-2, …
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Investigating the effects of aging and the neuromodulator retinoic acid on neurite outgrowth in a novel CNS organ culture
… aging impairs this process through changes in calcium handling, neurotransmitter sensitivity, and energy metabolism. In this thesis, I investigated agerelated changes in neurite outgrowth using a novel central nervous system (CNS) organ culture, in which outgrowth can be observed from cut …
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Nesfatin-1 Regulation of Cardiovascular Functions in Zebrafish and HL-1 Cardiomyocytes
… in the expression of Atp2a2a mRNA encoding the calcium-handling pump, SERCA2a, while it has no effects on the expression of calcium handling protein RyR1b encoding mRNA. NUCB2 mRNA and NUCB2/nesfatin-1 like immunoreactivity was detected in the cytoplasm of mouse HL-1 cardiomyocytes. High glucose …
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Force regulation in contractile cells by chemical and mechanical signaling
… cells. Chemical signaling by intracellu- lar calcium directly regulates heart contractions. Altered calcium handling in heart cells is known to affect force generation in the heart, leading deleterious effects resulting in cardiovascular disease. Chemical and mechanical signaling in epithelial …
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Angiotensin-(1-9) prevents cardiomyocyte hypertrophy via miR-129-3p/PKIA/PKA signaling pathway
… that angiotensin-(1-9) prevents intracellular calcium dysregulation and the activation of Calcineurin/NFAT signaling pathway at a transcription and protein level in a model of norepinephrine-induced cardiomyocyte hypertrophy. To further investigate the anti-hypertrophic mechanism of …
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Dysregulation of connexin-43 (cx43) in doxorubicin-induced cardiotoxicity
… highlighted a change in contractility and calcium handling in spheroids in response to DOX. Interestingly, parallel studies in cancer cells did not reveal significant changes in Cx43 expression in response to DOX, which may indicate that these effects are cardiac and vascular-cell specific. …
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Aerobic Exercise-Mediated Prevention Against Glucocorticoid Myopathy in Aged Skeletal Muscle
… changes to the contents of protein related to calcium handling, mitochondrial quality control, and glucocorticoid receptor in muscle. These findings define several important sexually dimorphic changes to aged skeletal muscle physiology in response to glucocorticoid treatment and define the …
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Magnesium Regulation of Calcium in Essential Hypertension
… and its impact on the functional ability of the calcium ATPase. Rats were fed either a magnesium-deficient or a magnesium-sufficient diet for 10 weeks, after which the calcium ATPase activity was measured in intact red blood cells (RBC). Free intracellular calcium [Ca<sup>2+</sup>]i accumulation …
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