Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"calcium dynamics"”.
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ULTRASTRUCTURAL NEURONAL MODELING OF CALCIUM DYNAMICS UNDER TRANSCRANIAL MAGNETIC STIMULATION
A paramount question in the study of Calcium (Ca2+) signaling is how this ion regulates a wide spectrum of cellular processes, which include: fertilization, proliferation, learning, memory, and cell death. All of these processes are the result of synaptic strengthening and weakening. Part of the …
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Spatio-Temporal Calcium Dynamics of the Interstitial Cells of Cajal
… in turn linked to the integrated transport of calcium between the endoplasmic reticulum (ER), through inositol-trisphosphate receptor (IP3R) release, and mitochondria, through the uniporter. In the intestinal regions, a non-specific cation channel (NSCC) is associated with the membrane …
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Stretch Injury Alters Calcium Dynamics and Actin Organization in Human Astrocytes
… the critical role of astrocytes—especially their calcium signaling dynamics—in driving post-injury pathology. This thesis investigates how human induced pluripotent stem cell (hiPSC)- derived astrocytes respond to mechanical strain, aiming to reproduce changes in astrocyte behavior that can …
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Shaping of Spike-Timing-Dependent Plasticity curve using interneuron and calcium dynamics
The field of Computational Neuroscience is where neuroscience and computational modelling merge together. It is an ever-emerging area of research where the level of biological modelling can range from small-scale cellular models, to the larger network scale models. This MSc Thesis will detail the …
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Analysing Mathematical Models of Intracellular Calcium Dynamics using Geometric Singular Perturbation Techniques
Oscillations in free intracellular calcium (Ca2+) concentration are known to act as signals in almost all cell types, transmitting messages which control cellular processes including muscle contraction, cellular secretion and neuronal firing. Due to the universal nature of calcium oscillations, …
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Calcium Dynamics Affecting Egg Production, Skeletal Integrity, and Egg Coloration in Ring-necked Pheasants (Phasianus colchicus)
… on Ring-necked Pheasants (Phasianus colchicus). Calcium limits the distribution of this species, which produces 7-15 eggs per clutch. They may renest up to 5 times per breeding season on a diet low in calcium. The first chapter examines egg production in laying hens on 7 different diets from …
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Calcium dynamics in dendrites and spines of spiny neurons in the somatosensory ‘barrel’ cortex of the rat
… with the patch-clamp technique to study the Ca2+ dynamics in dendrites and spines of spiny neurons of layer 4 of the somatosensory cortex in acute thalamocortical brain slices of young (P13-P15) rats. Back-propagating action potentials (bAPs) resulted in a transient rise in Ca2+ in all dendrites …
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Astrocytes Rescue Neuronal Health After Cisplatin Treatment Through Mitochondrial Transfer.
… Cisplatin induced abnormalities in neuronal calcium dynamics characterized by increased resting calcium levels, reduced calcium responses to stimulation with potassium chloride (KCl), and slower calcium clearance. The same dose of cisplatin that caused neuronal damage did not affect …
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Lateral Parabrachial Choline Acetyltransferase Neurons and the Decision to Eat
… to investigate the anatomical projections, the calcium dynamics, and the causal role of the LPBN ChAT neurons. Anatomical projection results were produced using CRE dependent viral vectors to express mRuby tagged synaptophysin, the highest output being the central amygdala. Calcium dynamics were …
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Dysregulated DJ1-Mediated Translation in Alzheimer's Disease
… It has been hypothesized that disrupted calcium signaling may cause the digression from healthy memory to mild cognitive impairment (MCI) and eventually AD; and the search for the source of calcium dyshomeostasis continues still. The goal of this thesis is to take a bottom up approach to …
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Control of Cardiac Hypertrophic Signaling by Inositol 1,4,5-Trisphosphate Receptors
Calcium plays an integral role to many cellular processes including contraction, energy metabolism, gene expression, and cell death. The inositol 1,4,5-trisphosphate receptor (IP3R) is a calcium channel expressed in cardiac tissue. There are three IP3R isoforms encoded by separate genes. In the …
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Synaptic Multimodal Imaging and Molecular Network Inference
… tandem live-fixed imaging to combine synaptic calcium dynamics or glutamate spiking information with multiprotein measurements. We also developed an integration of rolling circle amplification-based in situ methods, such as a reporter on gene specific translation. We analyzed, based on …
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TUNING AND TESTING DEVELOPING NEURAL NETWORKS
… localized — alter neural network dynamics, primarily using calcium as a unifying readout. Specifically, by manipulating the structural, oxidative, and electrophysiological pathways, this work elucidates multimodal impacts on calcium dynamics across the network. We study how the …
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The hemo-neural hypothesis : effects of vasodilation on astrocytes in mammalian neocortex
… used two-photon imaging to visualize astrocytic calcium dynamics in vivo while manipulating vasodilation in vivo. Pinacidil caused a 10-20% dilation in most vessels, a degree of dilation of similar magnitude to those naturally evoked by persistent sensory stimulation (e.g. in fMRI studies). We …
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Genetic characterisation of the Drosophila Mitochondrial Calcium Uniporter in physiological and neurodegenerative contexts
… pathobiology. Mitochondrial health and calcium signalling have come to the fore in the study of both conditions, and mitochondrial calcium dynamics, which play a crucial role in basal metabolism and cell death, have potential to be a key player in the disease process. Though …
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Oxysterols in Neurodegeneration and the Influence of Presynaptic α-Synuclein Phosphorylation
… neurons. Both 24S-HC and 27-HC impaired calcium signalling and disrupted neuronal network synchrony, reflecting compromised neuronal communication. At the subcellular level, oxysterols induced widespread organelle dysfunction, including impaired mitochondrial integrity, reduced lysosomal …
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Neural Circuit Dependence of Acute and Subacute Nociception in C. Elegans
… input to downstream neurons is through different dynamics of activation. The temporal dimension of neural circuits cannot be deduced by anatomical wiring, but must be measured directly. In my thesis, I have characterized and manipulated the dynamic properties of a classical nociceptor in C. …
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The role of locus coeruleus norepinephrine in reinforcement learning
… learning by studying the spatiotemporal dynamics of transient LC-NE release during learned behaviors, the impact of this release on behavior, and the effects of LC-NE on task representation and processing in cortical target regions. Using a go/no-go task where water-restricted mice must …
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The Direct Impact of Trimethelamine-N-Oxide on Cardiac Function
… communication (GJIC), intracellular calcium dynamics and transversal-tubule (T-tubule) both in acute and chronic TMAO challenge. Moreover, we also tested whether TMAO can enter cardiomyocytes directly. The results suggested that TMAO could enter cardiomyocytes through organic cation …