Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 107 for “"calcium channels"”.
-
Structure and function of potassium and calcium channels
In this thesis, potassium channels human Kv2.1 and rat Kv2.1, along with calcium channels Ca, 1.2, Ca, 3.1, and chimeras have been studied. These channels were expressed in Xenopuso ocytesf or electrophysiological experiments using two electrode voltage clamp. For protein expression studies,DNA was …
-
T-type calcium channels and human mesangial cell proliferation
… mesangioproliferative renal diseases. The T-type calcium channel (T-CaCN) has been proposed to play an important role in the proliferation of a number of non-excitable cell types, but T-CaCN expression and functional significance in MC is not known. The aim of this thesis was to investigate the …
-
Pharmacological regulation and function of store-operated calcium channels
… the plasma membrane and activate ORAI and TRPC channels to allow Ca²⁺ influx. In this thesis, the pharmacological aspects andregulatory mechanisms of SOCE were investigated using HEK293 cells overexpressing STIM1, ORAI or TRPC genes. The expression and function of TRPC channels and their spliced …
-
Voltage gated calcium channels – molecular targets for trigeminal neuralgia
… in genes that encode different voltage-gated calcium channels, a class of ion channel that are important players in pain pathways. Among them, mutations in the genes CACANA1A, CACNA1G, and CACNA1H, that encode CaV2.1, CaV3.1 and CaV3.2 channels, respectively, were investigated. First, we …
-
Characterization Of High-Voltage-Activated Calcium Channels In Retinal Bipolar Cells
… properties. Voltage-gated Ca<sup>2+</sup> channels could be particularly important underlying the diversified physiological properties of different BCs. In this dissertation, I investigated the high-voltage-activated (HVA) calcium current in retinal bipolar cells in mice. In the first part …
-
Study of Presynaptic Calcium Channels and a Novel Calcium Channel Calhm1
Calcium signaling is essential for all cellular processes. In brain these processes include basic synaptic transmission, modification of established synapses, elimination of synapses as well as elimination of whole neurons by way of apoptosis. In this thesis, we have studied two of these processes. …
-
Divalent Effects on Permeatin and Gating of T-type calcium channels
… and their membrane potential. Voltage gated calcium channels change both of these properties by allowing Ca2+ to enter the cell, causing membrane depolarization and the entry of Ca2+ which acts as important signaling molecule. Much research over the last few decades has gone into discovering …
-
T-type Calcium Channels in Arterial Smooth Muscle: Activity, Regulation and Function
Voltage-gated Ca2+ channels (CaV) are key regulators of excitation-contraction coupling in arterial smooth muscle. Despite evidence of T-type CaV channels in rodent smooth muscle, little is known of their regulation and function. This thesis sought to delineate T-type Ca2+ channels, ascertain if …
-
ACQUIRED ALTERATIONS IN THALAMIC T-TYPE CALCIUM CHANNELS IN MODELS OF NEURONAL HYPEREXCITABILITY
… with low-threshold, transient (T-type) Ca2+ channels participating in this activity. The focus of this thesis is on the molecular and physiological alterations in thalamic T-type Ca2+ channels arising from neuronal insults that result in the generation of abnormal brain rhythms. These studies …
-
Differential modulation of T-type voltage gated calcium channels by G-protein coupled receptors.
T-type voltage-gated calcium (Ca2+) channels play critical roles in controlling neuronal excitability, firing patterns, and synaptic plasticity, although the mechanisms and extent to which T-type Ca2+ channels are modulated by G-protein coupled receptors (GPCRs) remains largely unexplored. …
-
Forced-Exercise Alleviates Neuropathic Pain in Experimental Diabetes: Effects on Voltage-Gated Calcium Channels
… glucose-associated alterations of voltage-gated calcium currents (VGCC) in small diameter dorsal root ganglion (DRG) neurons. Using behavioral, nerve-electrophysiology and patch-clamp methodology we examined the functional consequences of forced-exercise (treadmill, 5.4 km/week) on VGCC in …
-
Molecular Characterization of the Regulatory Subunits of Voltage -Dependent Calcium Channels From Rat Heart
Voltage-dependent Ca2+ channels are multimeric proteins consisting of pore-forming alpha1 and regulatory alpha 2delta, beta, and gamma subunits. The alpha1 subunit is essential for current generation, voltage sensing and drug interaction, whereas the regulatory subunits modulate channel properties …
-
Involvement of N-type voltage dependent calcium channels in axon degeneration during experimental autoimmune optic neuritis
Der entzündliche Befall des Sehnerven stellt eine der häufigsten klinischen Manifestationen der multiplen Sklerose (MS) dar, einer chronisch entzündlichen Erkrankung des zentralen Nervensystems (ZNS). In der Folge einer Optikusneuritis entwickeln etwa 30-50 % der Patienten eine bleibende …
-
Insulin-Like Growth Factor-1 Regulation and Subunit Composition of Low-Voltage Activated Calcium Channels in Atrial Myocytes
… myocytes. Our data showed that LVA Ca$\sp{2+}$ channels were inhibited by AS-$\rm\beta\sb{all}.$ These results support the idea that atrial T-type calcium channel is encoded by a member of the $\rm\alpha\sb{1E}$ calcium channel genes and is composed of at least the $\rm\alpha\sb{1E}$ and $\beta$ …
-
The role of PLC, cPKC, L-type calcium channels and CAMKII in insulin stimulated glucose transport in skeletal muscle
There is no abstract available for this dissertation.
-
Influence of Thyroid Hormonal Status on Gene Expression for Calcium Channels in the Developing Olfactory Bulb and Cerebellum of the Postnatal Rat
… it appears that the expression for these calcium channel genes is differentially regulated. In terms of development, the expression is tied more closely to development in the cerebellum than in the olfactory bulb. While expression appears to be regulated developmentally and by thyroid …
-
IDENTIFICATION OF Cav 3.2 T-TYPE VOLTAGE GATED CALCIUM CHANNELS AS KEY MEDIATORS OF TARGETED INHIBITION OF HEPATOCELLULAR CARCINOMA BY AMPLITUDE-MODULATED RADIOFREQUENCY ELECTROMAGNETIC FIELDS
… influx through Ca v 3.2 T - type voltage - gated calcium channel (CACNA1H). This finding establish es a key functional role for Ca v 3.2 in control of HCC proliferation, and furthermore establishes this transmembrane protein complex as a main target for HCC - specific AM RF EMF.
-
MODULATION OF VOLTAGE-GATED CALCIUM CHANNEL BY A SYNAPTIC PROTEIN AND GANGLIOSIDE
Voltage-gated calcium channels play a vital role in triggering the vesicle release in presynaptic terminals. We have identified several molecules in modulating the calcium channel functions. One of our focus is snapin from presynaptic complex, and the other is gangliosides and anti-gangliosides …
-
Molecular and functional study of splice variations of the L-type voltage-gated calcium channel CaV1.2 alpha1-subunit
L-type (CaV1.2) voltage-gated calcium channels play critical roles in membrane excitability, gene expression, cardiac and smooth muscle contraction. Alternative splicing enriches the functional diversity of the pore-forming CaV1.2 alpha-1 subunit. Systematic screening of the human CaV1.2 alpha-1 …
Page 1 of 6