Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"calcium channel blockers"”.
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Investigating calcium channel blockers as antimalarials
… out at the University of Salford identified calcium channel blockers (CCBs) as potential antimalarial agents. A growing body of evidence has demonstrated the importance of calcium within the Plasmodium life cycle. Studies have shown CCBs and calmodulin inhibitors to exhibit antimalarial …
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Glutamate Excitotoxicty Activates a Novel Calcium Permeable Ion Channel in Cultured Hippocampal Neurons
… receptors leads to protracted intracellular calcium elevations triggering calcium mediated neurotoxic mechanisms culminating in delayed neuronal cell death. In addition, glutamate excitotoxicity induces a NMDA dependent extended neuronal depolarization mediated by continuous calcium influx …
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Modulation of Axonal Transmission by Metabolic Stress
… modulate the DCMD axon’s performance and what channels are involved in high-frequency signaling that may be a target for metabolic stress. To investigate metabolic stress, we compared azide, a mitochondrial toxin, with starvation of 1- and 4-days. We found azide caused a similar reduction in …
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The Roles of Ca2+ and cAMP in the Nematocyst Discharge of the Sea Anemone Tentacle
… cAMP.</p> <p>We also find that NANA stimulates calcium influx into isolated tentacle ectodermal cells and that the influx is sensitive to various L-type calcium channel blockers, including dihydropyridines. The coincidence of the desensitization region of the nematocyst discharge curve with …
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A Critical Assessment of the Role of Abscisic Acid and Calcium Ions in Regulating Stomatal Movements in Commelina communis L.
… appeared to be dependent on the availability of calcium ions. Synergism between calcium ions and ABA in suppressing stomatal opening was observed, and a factorial experiment revealed a highly significant interaction between calcium and abscisic acid. The effect of calcium appeared to be on the …
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Proteasome Inhibition As A Potential Anti-Breast Cancer Therapy: Mechanisms Of Action And Resistance-Reversing Strategies
… AMPK activation is primarily mediated by Calcium/Calmodulin-dependent Kinase Kinase β (CaMKKβ). This hypothesis is supported by pharmacological or genetic inhibition of CaMKKβ that leads to a decrease in proteasome inhibitor-induced AMPK activation. Additionally, the AMPK-activating …
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Clonal haematopoiesis of indeterminate potential and the role of inflammation in its association with atherosclerosis
… to demonstrate that statins, ezetimibe, calcium channel blockers and vitamin C may all represent promising therapeutic options to explore for CHIP prevention. In conclusion, the work presented in this thesis furthers our understanding of the bidirectional relationship between CHIP and …
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Commonly used medications and survival from ovarian cancer
… converting enzyme inhibitors (ACEIs), beta blockers (BBs), calcium channel blockers (CCBs) and thiazide diuretics (TDs)]) was defined as two or more fills for a given medication class during the year after diagnosis. Ovarian cancer-specific death was assessed starting one year after …
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Development of a model cell culture system in which to study early effects of neuropathy-inducting organophosphates
… of 2 classes of compounds (carbamates and calcium channel blockers) previously demonstrated to modify OPIDN in hens. The modifiers (aldicarb and verapamil) were used as a 5 minute pre-treatment, simultaneous treatment, and a 2 minute post-treatment. Significant prevention of most of …
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The effect of calcium channel blocking agents on cold induced cerebral edema in mice
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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PHARMACOLOGICAL MODULATION OF SARCOPLASMIC RETICULUM CALCIUM ATPASE AND CALCIUM RELEASE CHANNELS FOR MUSCLE CELL PROTECTIVE ACTION
… regulating Ca2+ homeostasis, the L-type Ca2+ channels (calcium channel blockers). Other agents, like beta blockers, indirectly target various elements, including sarcoplasmic reticulum (SR) Ca2+-ATPase (SERCA) and ryanodine receptors (RyRs). However, there are no pharmacological agents that …
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Cоx-2 inhibitоrѕ in Оeѕоphаgeаl Cаncer
… transformation in cells. Bronchodilators and Calcium channel blockers (CCB's) that relax the Lower oesophageal sphincter (LOS) may increase Gastro-Oesophageal reflux (GORD) and the risk of Oesophageal adenocarcinoma (OAC). Hence I carried out a case control study looking into any association …
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The cardiovascular profile of the low renin phenotype in a black South African population
… angiotensin blockade; and a positive response to calcium channel blockers, aldosterone blockade or diuretics. It is therefore questionable whether the activation of the RAAS has a causal role in the development of hypertension and its associated complications in Africans. Relationships between the …
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The impact of maternal chronic hypertension and chronic kidney disease on the risk of adverse pregnancy outcomes and long-term cardiovascular disease: a population-based epidemiology study
… with CH who were prescribed methyldopa (versus β-blockers) had 43%, 59%, and 44% increased odds of superimposed pre-eclampsia, preterm birth, and very preterm birth, but 66% lower odds of FGR. No differences in outcomes were found in women who were prescribed calcium-channel-blockers (versus …
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Blood pressure variability and the characteristics and outcomes of patients with intracerebral haemorrhage
… with intravenous α- and β-adrenoreceptor blockers and calcium channel blockers, and amongst patients who had their BP measured more frequently, and had larger reductions in their SBP and lower average SBP. The associations between higher mid-term SBPV during 2-7 days after acute ICH and …
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ΜΕΛΕΤΕΣ ΠΑΝΩ ΣΤΗ ΦΑΡΜΑΚΟΛΟΓΙΚΗ ΘΕΡΑΠΕΙΑ ΤΗΣ ΑΧΑΛΑΣΙΑΣ ΤΟΥ ΟΙΣΟΦΑΓΟΥ. Ο ΡΟΛΟΣ ΤΩΝ ΑΝΤΑΓΩΝΙΣΤΩΝ ΤΟΥ ΑΣΒΕΣΤΙΟΥ
WE STUDIED IN A DOUBLE BLIND FASHION WITH DLA CEBO THE EFFECTS OF VERAPAMIL AND NIFEDIPINE ON THE RESTING PRESSURE OF THE LOWER ESOPHAGEAL SPHINCTER AND THEAMPLITUDE OF CONTRACTION OF THE ESOPHAGEAL BODY USING MANOMETRY IN PATIENTS WITH ESOPHAGEAL ACHALASIA, AND TO DETERMINE THE EFFECTS OF THESE …
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Acclimatization to High-Altitude, Long-Term Hypoxia Alters BK Channel Structure and Function
… possible mechanisms for the left shift of the BK channel I-V relationship in native basilar artery myocytes from the two LTH groups. These mechanisms included: differential expression of the accessary BK -1 subunit; differential phosphorylation of the BK subunit; and splice variation of the BK …
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MAPK and pro-inflammatory mediators in the walls of brain blood vessels following cerebral ischemia
… excitatory neurotransmitters such as glutamate, calcium channel dysfunction, generation of oxidative stress and free radicals, activation of stress signaling, cell membrane disruption, inflammation, ultimately leading to necrotic and apoptotic cell death [1, 4, 15, 16]. The effect of ischemia on …