Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"calcium buffering"”.
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Mechanisms of Calcium Buffering and Aging in Neurons: Testing the Limits of Homeostasis
<p>Intracellular calcium ([Ca<sup>2+</sup>]i) is an ubiquitous second messenger that integrates multiple and diverse neuronal pathways that include development and maturation, gene expression, synaptic plasticity, transmitter release, excitability, and even cell death. Upon neuronal excitation the …
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Effect of oncomodulin on cytoskeletal actin dynamics.
… pathways. We hypothesize that modulation of calcium signaling through mobile calcium buffers alters intracellular actin dynamics in OHCs. Early studies of OHC lateral stiffness and motility suggest that calcium modifies the actin-based cortical cytoskeleton. An EF-hand calcium buffering …
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A possible role for intrinsic calcium buffers in the long- term adaptation of crayfish neurons
… have shown that LTA requires extracellular calcium and protein synthesis (eg. Hong and Lnenicka, Soc. Neurosci. Abstr. 17:1322) and appears to involve communication between the cell body and the nerve terminals. The present study examines the possibility that the reduction in transmitter …
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Modeling and Ion Mapping of Intracellular Calcium Distribution in Molluscan Neural Somata
… mechanism of rapid (time constants of 1-3 sec) buffering of intracellular calcium in molluscan cell bodies, a diffusion-reaction model was developed. The model took into account the binding reactions of Ca('2+) with a calcium-indicating dye (arsenazo III) and an endogenous Ca('2+) buffer. The …
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A quantitative study of neuronal calcium signaling
… by transmembrane voltage changes, while calcium levels within the cell communicate information on a much slower time scale. Calcium acts as a second messenger responsible for modulating neuronal excitability in many ways including the mediation of gene transcription in the cell and the …
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Proteomic Profiling of the mdx Animal Model for Duchenne Muscular Dystrophy
… suggest increased cellular stress, impaired calcium buffering, cytostructural alterations and disturbances of mitochondrial metabolism in dystrophin-deficient muscle tissue. Thus, the absence of the dystrophin isoform Dp427 and resulting reduction in dystrophin-associated glycoproteins in the …
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Investigating novel therapeutic approaches and targets to prevent synapse degeneration
… characterized protein, primarily known for its calcium buffering capacities and high levels of expression in a subpopulation of interneurons. In this work, we show calretinin is expressed in previously unreported cell populations, including motor axons and synapses from the peripheral nervous …
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Frequency Selectivity of Synaptic Exocytosis in Hair Cells of the Bullfrog's Amphibian Papilla
… selectivity, and a conspicuous gradient in Ca 2+ buffering may help to keep the system poised near maximal sensitivity.</p>