Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 8 of 8 for “"calcium/calmodulin-dependent protein kinase II"”.
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Calcium/Calmodulin-Dependent Protein Kinase II Beta (CaMKIIβ): A Regulator of Oligodendrocyte Maturation and Myelination
… as part of my thesis provided evidence that CaMKII (more specifically CaMKIIβ) is a regulator of oligodendrocyte myelination and maturation. Using pharmacological inhibitors or siRNA-mediated knockdown of this protein resulted in improper formation of the oligodendrocyte process network. …
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The Impact of Calcium Binding Protein 5 (CaBP5) on Synaptic Vesicle Dynamics in Rod Bipolar Cells in the Retina
<p>Calcium binding protein 5 (CaBP5) is a retina-specific protein, specifically expressed in rod bipolar cells and in type 3 OFF and type 5 ON cone bipolar cells. Rod bipolar cells (RBCs) are essential for rod pathway signaling in the vertebrate retina, and they form ribbon style synapses that …
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The role of Substance P and its signaling pathways in central sensitization
… has also demonstrated that several important protein kinases are involved in central sensitization evoked by SP. The second part of this study is to investigate the contribution of secondary messengers, such as calcium/calmodulin-dependent protein kinase II (CaMKII) and protein kinase C (PKC), …
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Induction and Maintenance of Synaptic Plasticity
… synapse. The biochemical network involving calcium/calmodulin-dependent protein kinase II (CaMKII) and its regulating protein signaling cascade has been hypothesized to durably maintain the synaptic state in form of a bistable switch. Furthermore, it has been shown experimentally that CaMKII …
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THE PROTECTIVE EFFECTS OF CHRONIC CAFFEINE TREATMENT ON THE COGNITIVE FUNCTION AND SYNAPTIC PLASTICITY IN ACUTE SLEEP DEPRIVATION
… deleterious effects of sleep loss on hippocampus-dependent learning and memory. Experimental design: We investigated the effects of chronic (4 weeks) caffeine treatment (0.3 g/l in drinking water) on memory impairment in acutely (24 hr) sleep-deprived rats. Sleep deprivation was induced using the …
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The roles of αCaMKII and Ras-GRF2 in the establishment of drug addiction
… separate genes, each of which code for different proteins involved in synaptic plasticity. The thesis aims to assess whether these genes contribute to the development of drug preference and addiction, and the speed at which these behaviours are established. Alpha calcium/calmodulin dependent …
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Oxysterols in Neurodegeneration and the Influence of Presynaptic α-Synuclein Phosphorylation
… neuronal dysfunction, often driven by protein misfolding and chronic cellular stress. Among the emerging contributors to these pathologies is disrupted cholesterol metabolism, particularly the accumulation of oxidised cholesterol derivatives known as oxysterols. Notably, …
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Influence of Sodium Channel Activation on NMDA Receptor-Mediated Structural Plasticity.
… during development. Many aspects of activity-dependent neuronal development such as dendritic arborization, spinogenesis and synaptogenesis are mediated via N-methyl D-aspartate receptor (NMDAR)-dependent signaling mechanisms. Inasmuch as neuronal activity involves activation of voltage-gated …