Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"calcitonin receptor"”.
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Molecular and Pharmacological Characterization of the Rat RAMP2B Splice Variant
Receptor activity-modifying protein 2 (RAMP2) forms a hetero-oligomer with the calcitonin receptor-like receptor (CL) homo-oligomer to produce the adrenomedullin receptor 1 (AM1). RAMP2 has also been shown to associate with other receptors including the calcitonin receptor (CTR), vasoactive …
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Investigating the molecular pharmacology of class A and B G protein-coupled receptors
G protein-coupled receptors (GPCRs) possess an inherent ability to bind to an extremely diverse range of ligands and activate multiple downstream signalling pathways. It is becomingly increasingly evident, however, that for many GPCRs, the exact downstream signalling cascade(s), and the extent of …
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Insight into G Protein-Coupled Receptors through Molecular Dynamics Simulations
… in this PhD thesis to study G protein-coupled receptors (GPCRs),one of the largest families of proteins in the mammalian genome. In particular two receptors have been analysed: free fatty acid receptor 1 (FFAR1) and calcitonin receptor (CTR), respectively belonging to class A and class B of …
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Estrogen Receptor Ligands and Regulation of Gene Expression
Keratin13 (KRT13) and calcitonin receptor (CALCR) gene expression is differentially regulated by estradiol (E2) and the selective estrogen receptor modulators (SERMs) tamoxifen and raloxifene. KRT13 is a cytoskeleton protein while CALCR mediates the biological effects of calcitonin. These two genes …
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Sites of interaction between calcitonin-family peptides and their receptors
The calcitonin-family of peptides comprises calcitonin, amylin, calcitonin gene-related peptides (CGRPs), adrenomedullin (AM) and AM2. Their receptors are calcitonin receptorlike receptor (CLR) or calcitonin receptor (CTR) and receptor activity-modifying protein (RAMP) complexes. RAMP1 with CLR …
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CGRP family of G protein-coupled receptors and their signalling in human cardiovascular cells
… properties of a unique family of cell surface receptors known as G protein-coupled receptors (GPCRs), and one of their subclasses: The CGRP receptor family. These receptors are crucial for transducing information from the extracellular to intracellular space. While much pharmacological research …
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Computational and experimental investigation of G protein-coupled receptor signalling mechanisms
G Protein-Coupled Receptors (GPCRs) are 7-transmembrane domain proteins. These receptors translate extracellular stimuli into cellular responses through heterotrimeric G proteins and β-arrestin proteins. These receptors are of considerable therapeutic interest, targeted by over 500 drugs approved …
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Regulation Mechanisms of Peptide Hormones in Neuroendocrine Cancers
… These methods were used to detect and quantify calcitonin (CT) and its prohormones glycyllysyllysine-extended CT (CTGKK), glycyllysine-extended CT (CTGK) and glycine-extended CT (CT-G) for the first time, in DMS53 small cell lung carcinoma (SCLC) cell culture medium and lysate. Additionally, …
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Regulation Mechanisms of Peptide Hormones in Neuroendocrine Cancers
… These methods were used to detect and quantify calcitonin (CT) and its prohormones glycyllysyllysine-extended CT (CTGKK), glycyllysine-extended CT (CTGK) and glycine-extended CT (CT-G) for the first time, in DMS53 small cell lung carcinoma (SCLC) cell culture medium and lysate. Additionally, …