Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"calcitonin gene related peptide"”.
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Calcitonin Gene-Related Peptide Promotes Wound Healing of Cornea
… are implicated in the wound healing process. Calcitonin gene-related peptide (CGRP), a 37-amino acid neuropeptide, is a biologically active protein that has many functions throughout the nervous system including promoting vasodilation and cell proliferation. Based on the expression of CGRP and …
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Calcitonin Gene-Related Peptide Promotes Peripheral and Central Trigeminal Sensitization
… goal of my study was to investigate the role of calcitonin gene-related peptide (CGRP) on the initiation and maintenance of a nocifensive withdrawal response to mechanical stimulation following activation of primary trigeminal sensory neurons. For my studies, I used adult male Sprague Dawley rats …
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Design, Synthesis and Pharmacological Characterization of Novel Calcitonin Gene-Related Peptide Receptor Antagonists
ABSTRACT|Human-a-calcitonin gene-related peptide (CGRP) is a 37 amino acid residue neuropeptide produced from tissue-specific alternative splicing of the primary RNA transcript of the calcitonin gene. CGRP is widely distributed throughout the central and peripheral nervous systems and is involved …
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Modulation of the vascular function by cannabinoids, calcitonin gene related peptide and connexin hemichannels
… we characterized the targets of cannabinoid- and calcitonin gene related peptide (CGRP)-triggered vasodilation and the role of connexin channels in the modulation of blood vessel tone. Additionally, we investigated connexin channels as a putative target to protect blood vessels against cell death …
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Serum calcitonin gene-related peptide concentrations in the horse and their relationship to the Systemic Inflammatory response
… continues. The serum concentration of both procalcitonin and its related molecule CGRP have been documented to increase in humans with SIRS, yet no literature exists as to the production or role of CGRP in equine patients with SIRS. This study showed that equine CGRP was produced in detectable …
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Genetic Dissection of DH31 Signaling in Drosophila
Dh31, which is homologous to the mammalian Calcitonin Gene-Related Peptide, is a multifunctional neuropeptide in Drosophila. To evaluate the roles of Dh31 signaling in Drosophila, we took advantage of the KG09001 line because it has a transposable element inserted in the third intron of the Dh31 …
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Central Role Of CGRP And Protein Kinase A In Promoting Trigeminal Sensitization In An In Vivo Model Of Temporomandibular Joint Disorder
… and hyperalgesia. Elevated levels of the neuropeptide calcitonin gene-related peptide (CGRP) in the joint capsule and upper spinal cord are implicated in the underlying pathology of TMJD. The cellular effects of CGRP are mediated by increases in the activity of the protein kinase A (PKA), a …
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Using knockout mice to study the molecular mechanisms that shape auditory nerve responses
The ease of targeted genetic modification makes the mouse a valuable model to study hearing and deafness. A powerful window into cochlear function can be obtained by recording from single auditory (AN) fibers, primary afferents connecting cochlear inner hair cells to the brain. This thesis provides …
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The gastrointestinal effects of calcitonin and related peptides
… the anti-ulcerogenic properties of the hormone calcitonin and some related peptides have been investigated. The hypocalcaemic actions and the actions on indomethacin-induced gastric erosions of calcitonin, icatacalcin and calcitonin gene-related peptide (CGRP) were found to be very different. …
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Functional Roles of A1-adrenergic Receptors in the Bovine Inferior Alveolar Artery: Regulation of Contraction and Activation of Extracellular Signal Regulated Kinase
… 5-hydroxytryptamine (5-HT), acetylcholine (ACH), calcitonin gene-related peptide (CGRP) and norepinephrine (NE) on vascular tone in the BIAA using functional measurements of contraction. 5-HT potently contracted BIAA rings with an BC50 = 0,81 ± 0.28 pM and was used to pre-contract rings …
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CGRP family of G protein-coupled receptors and their signalling in human cardiovascular cells
… of the pharmacology of endogenous human calcitonin receptor-like receptor (CLR) in its native cellular environment. Therefore, primary human cardiovascular cells, gene editing techniques, and a host of intracellular assays were used to study the signalling properties of this GPCR family, …
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Molecular imaging with engineered physiology
… their own technical constraints and so far lack generality. Here, we introduce a conceptually novel molecular imaging technique based on artificially induced physiological perturbations, enabling molecular MRI with nanomolar sensitivity. In this imaging strategy, we take advantage of blood as an …
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Effects of Neurotrophic Factors on Osteoblast Growth and Differentiation
… of osteogenic growth factors in the form of neuropeptides. These neuropeptides could act locally on osteoblasts to increase bone formation and/or mineralization. Since calcitonin gene-related peptide (CGRP) and Substance P (SP) are the most abundant neuropeptides present in sensory nerves in bone, …
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Role of CGRP in the amygdala in pain-related synaptic plasticity and behavior
… In particular, arthritic pain is closely related to affective disorders such as anxiety and depression. A key player in the emotional evaluation of sensory stimuli, the amygdala has been suggested as a neural substrate of the reciprocal relationship between pain and affect. Nociceptive …
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Distribution and function of TRP ion channels in primary sensory neurons
… and HU210 also fail to inhibit TRPV1-mediated calcitonin gene-related peptide (CGRP) release from primary sensory neurons in rat hindpaw skin and mesenteric artery. Therefore, this study do not support the general view that the analgesic and anti-inflammatory effects of CB1 receptor agonists …
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Osteoneogenese und Innervation des interfragmentären Raumes durch neuropeptidpositive Fasern am Beispiel des Distanzosteosynthesemodells der Kaninchentibia
… neuropeptidpositive Nervenfasern, vor allem das Calcitonin gene-related peptide (CGRP). Daten und Fakten zu Vorkommen, Verteilung, Struktur, Sequenz und Biochemie des Peptids, wie sie die aktuelle internationale Literatur dokumentiert, ergänzen den experimentellen Teil der Arbeit. An der Tibia …
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Biphasic neurogenic vasodilatation in the bovine intraocular long posterior ciliary artery
… by the neurotransmitters nitric oxide (NO) and calcitonin gene related-peptide (CGRP). 2.This study of the bovine intraocular LPCA, where a short period of EFS (10 s) was employed, demonstrated that the vasodilator response to EFS was in fact biphasic. The first and second components of the …
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SEX DIFFERENCES IN GENE EXPRESSION AND PAIN-RELATED BEHAVIORS IN A PRECLINICAL MODEL OF MIGRAINE
… symptoms with changes in the activity of pain-related neurotransmitters and neuromodulators, such as calcitonin gene related peptide (CGRP). A vasoactive neuropeptide, CGRP might contribute to the vasodilatory component of migraine, and to the pain associated with this condition as it is …
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