Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 6 of 6 for “"calcineurin signaling"”.
-
Investigating the Role of the PGF2 Alpha/Calcineurin-Signaling Pathway in the Regulation of Adipogenesis
… of the calcium-regulated protein phosphatase, calcineurin. In this current study, we have now extended these findings to identify the IL-11 cytokine and the Nurr1 orphan nuclear hormone receptor as functionally important downstream transcriptional targets of the PGF2α/calcineurin-pathway …
-
Sexual Reproduction and Signal Transduction in the Candida Species Complex
… the second and third chapters we examine the calcineurin signaling pathway, which is crucial for mediated tolerance to cellular stresses including cations, azole antifungals, and passage through the host bloodstream. First, we show that clinical use of calcineurin inhibitors in combination …
-
Roles of Class II Histone Deacetylases in the Cardiovascular System
… heart becomes profoundly enlarged in response to calcineurin signaling and pressure overload. The cardiac phenotype of HDAC5 mutant mice is remarkably similar to that of HDAC9 mutant mice, strongly suggesting that these two HDACs play comparable roles in the control of cardiac growth. HDAC 5 and 9 …
-
FHL2 Inhibits Calcineurin and Represses Pathological Cardiac Hypertrophy
… hypertrophy relies on activation of the calcineurin-NFAT pathway, and inhibition of calcineurin is sufficient to block growth in response to isoproterenol. I also observed that FHL2 is up-regulated in mouse hearts after isoproterenol treatment. Based on this, we hypothesized that FHL2 …
-
Endosomal Trafficking as a Determinant of Antifungal Tolerance in the Pathogenic Fungus Candida albicans
… levels of intracellular calcium and enhanced calcineurin activity, as evidenced by increased expression of a calcineurin responsive RTA2-GFP reporter construct in response to fluconazole. Furthermore, the azole tolerant phenotype of the vps21Δ/Δ mutant is dependent upon both calcium and …
-
Dissecting Synaptic Vesicle Endocytosis
… for the Ca<sup>2+</sup> dependent phosphatase, calcineurin. Removal of the F-Bar domain protein syndapin 1, a dynamin 1 binding partner that requires dynamin 1s dephosphorylation, also distorted the acceleration. We examined the setpoint of synaptic vesicle endocytosis between boutons, between …