Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"caged compounds"”.
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Caged phosphopeptides and phosphoproteins : agents in unraveling complex biological pathways
… the roles of phosphoproteins include photolabile caged analogs of bioactive species. Caged compounds are ideal chemical probes for studying cellular signaling because they afford researchers spatial and temporal control over the release of targeted effector molecules. Ligands or proteins involved …
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Femtosecond pulse shaping for enhanced optical imaging and control of cells
… of optical probes: fluorescent molecules, caged compounds, and opsins.
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Von der Form zur Richtung
… and release of cAMP from biological inactive caged compounds the directional response of neuronal growth cones was investigated. Intracellular gradients were induced by asymmetric release of cAMP on one side of the growth cone. Using a new method, which released the same amount cAMP …
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Triggerable ligand presentation using caged-RGD
… engineer biomaterials that present a UV-labile caged-Arginine-Glycine-Aspartic Acid (RGD) ligand and evaluate the effects on cell activities. RGD is the minimal adhesive sequence of fibronectin. By dynamically modulating adhesive ligand presentation, the effects of temporal control on cell …
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ALPHA4BETA2 NEURONAL NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS: FROM SUBTYPE SELECTIVE TO STOICHIOMETRIC ISOPHORM SELECTIVE PARTIAL AGONISM.
… design, synthesis, and biological evaluation of compounds selective for the orthosteric and unorthodox binding sites of the α4β2 nAChRs. In the second part, attention is paid to the study of a photoactivatable α4β2 nAChRs full agonist. Part 1 The first goal of Part 1 was the mutational studies of …
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Synthese und Photochemie von photoaktivierbaren Biomolekülen
… photoaktivierbarer Biomoleküle, sogenannter caged Verbindungen, möglich geworden. Bei den caged Verbindungen handelt es sich um photolabile inaktive Derivate von biologisch aktiven Molekülen, aus denen durch ultraviolettes Licht mit Hilfe einer photochemischen Reaktion die natürliche, …
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SYNTHESIS, CHARACTERIZATION AND EVALUATION OF BIOACTIVE MOLECULES LINKED TO PHOTOREMOVABLE PROTECTING GROUPS FOR SPATIO-TEMPORAL CONTROL OF THEIR ACTIVITY THROUGH PHOTOACTIVATION
… generally referred to as photo-prodrugs or caged compounds, are able to release the native drug upon light irradiation at a specific wavelength, which cleaves the bond between the PPG and the bioactive molecule. In the literature, several classes of PPGs have been described, including …