Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 62 for “"cachexia"”.
-
Insulin resistance in cancer cachexia and metabolic syndrome
… incidence of metabolic-related diseases. Cancer cachexia (CC) and Metabolic syndrome (MetS) are both multifactorial highly complex metabolism related syndromes, whose etiology is not fully understood, as the mechanisms underlying their development are not completely unveiled. Nevertheless, …
-
Purification and characterisation of two cancer cachexia factors
Cachexia is a wasting phenomenon that often accompanies malignant disease. Its manifestation is associated with shortened survival and reduced responsiveness to anti-tumour therapy and as yet there is no established, effective amelioratory treatment. The MAC 16 model of cancer cachexia has been …
-
The host response to cancer and cancer-associated cachexia
Cachexia, a severe wasting syndrome, affects up to 90% of patients with cancer and causes significant morbidity and mortality worldwide. Patients with cachexia suffer from weight loss, anorexia, sarcopenia, and behavioural changes that eventually lead to death. Given its incidence and prevalence, …
-
Characterizing PDK4 and PKC-Theta in Pancreatic Cancer and Cachexia
Cachexia is an involuntary wasting syndrome that cannot be reversed by nutritional support. It affects most patients with pancreatic ductal adenocarcinoma (PDAC) and is believed to cause 20% of cancer-associated deaths. Cachectic patients exhibit both metabolic abnormalities and systemic …
-
Cellular signalling pathways involved in muscle atrophy in cancer cachexia
Cancer cachexia encompases severe weight loss, characterised by the debilitating atrophy of adipose and skeletal muscle mass. Skeletal muscle proteolysis in cancer cachexia is mediated by a sulphated glycoprotein with a relative molecular mass of 24kDa, termed Proteolysis-Inducing Factor (PIF). PIF …
-
Investigation into the mechanisms responsible for muscle atrophy in cancer cachexia
Cachexia inducing tumours are known to produce a glycoprotein called proteolysis inducing factor (PIF), which induces skeletal muscle atrophy via increased protein degradation and decreased protein synthesis. The objective of this study was to investigate the signalling pathway by which PIF reduces …
-
To assess the effectiveness of tailored food recipe in attenuating the progression of cancer cachexia to refractory cachexia in adult female patients undergoing palliative care in India
Cancer cachexia negatively impacts patients’ capability to undergo chemotherapy and fight infection. Increased energy expenditure and anorexia are key clinical features among cachexia patients leading to body weight loss. Therefore, it is imperative to assess all cancer patients for early signs of …
-
The Potential of Non-Steroidal Anti-Inflammatory Drugs (NSAIDS) in Cancer Cachexia
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
-
The mode of action of a lipid mobilising factor in cancer cachexia
Cachexia is characterised by a progressive weight loss due to depletion of both skeletal muscle and adipose tissue. The loss of adipose tissue is due to the production of a tumour-derived lipid mobilising factor (LMF), which has been shown to directly induce lipolysis in isolated epididymal murine …
-
Comparative Plasma Proteomics in Muscle Atrophy Induced by Cancer Cachexia and Hindlimb Unloading
… into the right hind-flank to induce cancer cachexia. Tumors developed for approximately 4 weeks. Age-matched mice were humanely euthanized after experimental intervention. Muscle and plasma were collected for analysis. Plasma was analyzed by tandem mass tag (TMT) proteomics. Results: Raw …
-
The role of Protein Degradation in Cancer Cachexia in Female Tumor Bearing Mice
… by this disease die from its effects. Cancer-cachexia is a syndrome associated with the significant loss of skeletal muscle mass and function, which cannot be fully reversed by nutritional intervention alone and in turn, impairs the host. Cancer-cachexia affects 50-80% of cancer patients and …
-
Skeletal Muscle Protein Turnover During Cancer Cachexia In the Apc<sup>min/+</sup> Mouse
<p>Cancer cachexia is a complex wasting condition associated with the loss of skeletal muscle and fat mass. Muscle wasting exhibits an imbalance in the rate at which proteins are synthesized and degraded, referred to as protein turnover. Our laboratory has shown the ApcMin/+ mouse, a model of …
-
The role of stress-derived vesicles in the bystander effect and cancer related cachexia
… also been implicated in the induction of cancer-cachexia, a muscle wasting disease. This disease is common in patients with cancer and is often linked to poor prognosis. In this project the ability of EVs released from heat shocked cells to induce bystander effects has been assessed. EVs released …
-
The nature of cachexia in patients with heart failure and stable coronary artery disease
Cachexia is a prognostically important development in patients with heart failure. The most commonly used definition of cardiac cachexia is loss of a percentage of body weight over time. Muscle wasting has been assumed to be the major contributor to this weight loss, and cytokine activation is …
-
Differential BCAA Metabolism in Tissues of Tumor-Bearing Mice: A Path to Understanding Cancer Cachexia
Cancer cachexia is a complex syndrome marked by muscle and fat loss, often resistant to nutritional support. While branched-chain amino acids (BCAAs) stimulate muscle protein synthesis, BCAA-targeted therapies have shown inconsistent results. In this study, a C26 colon cancer mouse model was used …
-
The Effect of Cancer Cachexia Progression on the Feeding Regulation of Skeletal Muscle Protein Turnover
<p>Cancer cachexia is defined as the unintentional loss of skeletal muscle mass with or without fat loss that cannot be reversed by conventional nutritional support. Cachexia occurs in ~20% of cancer patients. More specifically, 50% of lung cancer patients, the most common cancer worldwide, develop …
Page 1 of 4