Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"cMet"”.
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Molecular Insights and Physiological Consequences of Aryl Hydrocarbon Receptor Regulated Plasminogen Activator Inhibitor-1 Expression
… activated, HGF signalling through its receptor cMet is a crucial component early in regeneration. Recent studies identified a sequence distinct from the canonical AhR binding site, the ncXRE, which confers TCDD-inducible expression to the PAI-1 promoter. Since the ncXRE shares partial sequence …
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Basis For Targeting Met Activation Mediated Resistance to Pi3K Inhibition In Breast Cancer
… acquisition of resistance.</p> <p>We analyzed cMET and phospho-cMET levels in 257 breast cancer samples and found that high levels of both the proteins were seen in all breast cancer subtypes, which correlated with poor prognosis.(<a …
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Regulation of hepatocyte growth factor receptor endocytic trafficking
The Hepatocyte Growth Factor Receptor (HGFR/cMet) is a receptor tyrosine kinase that is essential for multiple cell responses, including cell proliferation, survival, motility and branching morphogenesis. Normal HGFR signaling regulates embryonic development, organ regeneration and wound healing, …
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The Role of Ribosomal Maturation Proteins WBSCR22 and EMG1 Methyltransferase Activity in Cancer
… drivers of metastatic uveal melanoma such as cMET. Finally, the therapeutic potential of WBSCR22 catalytic inactivation was explored for the first time as a putative anti-metastatic combination therapy with crizotinib. Preliminary data show that sub lethal concentrations of crizotinib are …