Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"cJUN"”.
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In vitro exploration of interactions between junctin and the Ryanodine receptor from skeletal and cardiac muscle
… and bulky, highly charged C-terminal domain (Cjun), that are exposed to the cytoplasm and SR lumen respectively. Although originally thought to function as a linker between the SR calcium binding protein (calsequestrin) and RyRs, recent studies suggest the junctin may have a more complex role …
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In vitro exploration of interactions between junctin and the Ryanodine receptor from skeletal and cardiac muscle
… and bulky, highly charged C-terminal domain (Cjun), that are exposed to the cytoplasm and SR lumen respectively. Although originally thought to function as a linker between the SR calcium binding protein (calsequestrin) and RyRs, recent studies suggest the junctin may have a more complex role …
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A single molecule approach to investigate how AP1 transcriptional regulators find their target sites on DNA
… to the initiation of cancer. Regulating cFos and cJun interactions with AP1 binding sites is a potential cancer therapy strategy. How the proteins find their target sites and whether non-specific DNA binding occurs will be investigated. The Protein Fragment Complementation Assay (PCA) derived …
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Régulation de l'expression du gène Gja1 impliqué dans la formation de jonctions communicantes au niveau du testicules de souris
… Sox (Sox4, Sox8 e tSox9) ainsi qu’AP-1(cJun et cFos) avec des 5 plasmides rapporteurs de la luciférase portant différentes longueurs du promoteur Gja1. Enfin, le recrutement des facteurs de transcription à leurs éléments de régulation sur le promoteur Gja1 fut mesuré par …
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Characterizing the role of p21-Activated Kinase 3 (PAK3) in AP-1-induced transformation
… of PAK3 expression and the role of PAK3 in cJun/AP-1-associated cellular transformation. Our results showed elevated PAK3 expression at both the mRNA and protein level in cJun-over-expressing Rat1a fibroblasts, as well as in transformed human fibroblasts. Elevated PAK3 protein levels were …
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Transient Metabolic Alterations Induced by Chemotherapeutics in Cancer Persisters
… and western blotting, we identified that the cJUN pathway was transiently upregulated in cultures treated with chemotherapeutic agents. We further show that co-treatment with a cJUN inhibitor, JNK-In-8, resulted in an increased survival rate in cancer cells in the presence of chemotherapeutic …
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The scaffold protein POSH regulates T lymphocyte function
… immune response. T cell receptor (TCR) mediated cJUN NH2-terminal kinase (JNK) activation is required for mounting proper T cell mediated immune responses. However, little is know as to how JNK activation is coupled to the TCR. This dissertation shows that the scaffold protein Plenty of SH3s …
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Microglial Modulation of Neuronal Autophagy: Uncovering Cytokine-Mediated Pathways
… of the JNK pathway, as shown by increased cJUN phosphorylation, and this effect was reversed by JNK inhibition. These findings highlight the significance of CXCR5 and CXCR3 signalling in modulating autophagy and suggest potential therapeutic targets for neurodegenerative diseases.
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Investigating the role of histone H3 lysine 9 dimethylation in regulating disease-associated vascular smooth muscle cell gene expression
… binding of the AP-1 transcription factor cJUN to the MMP3 promoter. Collectively, these findings suggest that H3K9me2 plays a role in maintaining the contractile VSMC state and prevents binding of both NFkB and AP-1 transcription factors at specific IL-1α-regulated genes to possibly block …
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Molecular Regulation of Opioid Receptor Signaling
… of action resulting from selective activation of cJun kinase (JNK). In this thesis, I compared the signaling events initiated by agonist stimulation of hKOR and rKOR. Although a partial agonist at both hKOR and rKOR, pentazocine was more potent at activating p38 MAPK in hKOR than rKOR expressed in …
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The Influence of a Single Nucleotide Polymorphism In The Matrix Metalloproteinase-1 Promoter on Glioma Biology
… ERK pathway. AP-1 transcription factor proteins, cJun and cFos were increased in response to HGF treatment but not Ets-1 and ETV-1. HGF/SF treatment of glioma cell lines differing in their MMP-1 genotype affected binding of ETS and AP-1 proteins to the endogenous MMP-1 distal promoter. Using …
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THC-MEDIATED INDUCTION OF ΔFOSB AND ITS MODULATION OF CB1R SIGNALING AND ADAPTATION
… of ΔFosB, or its dominant negative ∆cJun, determined that ΔFosB regulates CB1R signaling and reduces CB1R desensitization. Based on this regional profile, studies determined the role of dopamine signaling in THC-mediated ∆FosB induction. Results showed that THC-mediated induction of …
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Endogenous retroviral proteins as potential drug targets for merlin-deficient tumours
… elevated expression of the transcription factor cJun. Env o/e also increased pERK1/2 activity and upregulated S phase cyclin A2. I have also revealed that HERV-K Env overexpression is regulated by TEAD-mediated transcription both in Merlin-deficient schwannoma and grade I meningioma. Furthermore, …
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Molecular Mechanisms Governing Persistent Induction of Pro-Inflammatory Genes by Lipopolysaccharide
… At this dose, only the persistent activation of cJun N-terminal kinase (JNK) and C/ebpδ was observed. IL-6 transcription requires the transient recruitment of activating transcription factor 2 (ATF2) and the persistent recruitment of C/ebpδ to the IL-6 promoter. In the third study, the molecular …
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Natural product derivative activates autophagy in cancer cells
… cells with EXP57EA stimulated phosphorylation of cjun and resulted in elevated levels of total c-jun. These results suggested the JNK pathway might also be involved in EXP57EA-induced cell death. However, the proposed involvement of the PERK/eIF2α pathway and the JNK pathway in EXP57EA-mediated …
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Identifizierung und funktionelle Analyse der humanen Xylosyltransferase I- und II-Promotoren
… involved. The findings of my thesis were that cJun/AP-1 and Sp1 proteins essentially participate in the regulation of the XYLT1 gene. This was confirmed by using specific antibodies and sequence specific siRNA targeting Sp1 and Sp3. Additionally, a crucial role of Sp1 transcription factors in …
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The control of Schwann cell myelination during development and after nerve injury
… On the other hand, transcription factors cJun, Pax3, Id2 and signalling pathways Notch and p38 mitogen activated protein (MAP) kinases (MAPK) have been identified as negative regulators of Schwann cell differentiation and myelin formation. Recently, the HMG transcription factor Sox2 was …
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Expression and regulation of N-Myc Downstream- Regulated gene 1 in squamous cell carcinoma of the oesphagus
… (ChIP) assays, we showed that both EGR-1 and cJun/AP-1 are capable of driving transcription of NDRG1 in response to 12-o-tetradecanoylphorbol- 13-acetate (TPA) through activation of PKC/MEK/ERK1/2 and JNK MAPK pathways. Taken together, we describe the regulation of NDRG1 expression by EGR-1 …
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Implication des voies de signalisation associées au calcium dans la régulation des jonctions communicantes au niveau testiculaire
… les facteurs AP-1, notamment les facteurs cJUN et cFOS, semblent être des facteurs clés qui sont importants pour la régulation du gène Cx43 en collaboration avec CaMKI dans les cellules de Leydig. Ainsi, la caractérisation de la voie de signalisation des CaMKs comme régulateur du promoteur …
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Role of N6-Methyladenosine (m6A) epitranscriptomic mechanisms in manganese-induced astrocyte inflammation
… reduce the downstream activation of JNK and cJUN phosphorylation of Mn exposed astrocytes, and thus, attenuating their pro-inflammatory, proliferative, and survival signaling responses. Collectively, the exploration of this dissertation suggests astrocytes have multiple mechanisms that are …
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