Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 5 of 5 for “"cIAP1"”.
-
Investigating the Role of the Inhibitor of Apoptosis Proteins (IAPs) in Metastasis Formation
… is promoted specifically by cellular IAP1 (cIAP1), and not by other IAPs, and that SM83-dependent down-regulation of SNAI2 reduces cancer cell motility. Accordingly, cIAP1 depletion blocks epidermal growth factor receptor (EGFR)-dependent activation of the mitogen-activated protein kinase …
-
Novel Role of CHK2 in the Intrinsic and Extrinsic Apoptosis Pathway
… In response to DNA damage, CHK2 inhibits both cIAP1 and cIAP2 to relieve their anti-apoptotic effects and drive cells into apoptosis. CHK2 inhibits the E3 ubiquitin ligase activity of cIAP2 in a phosphorylation dependent manner and potentially regulates cIAP1 through its interaction with cIAP2. …
-
Finding NEMO by the molluscum contagiosum virus MC159 protein and its effect on viral pathogenesis in vivo
… Briefly, I found that MC159 antagonizes cIAP1-NEMO interactions to inhibit NEMO polyubiquitination and thus NF-kB activation. This is a novel finding of a viral protein to disrupt NEMO-cIAP1 interactions to strategically suppress IKK activation (Chapter II). I also found that MC159 can …
-
Existence of Inhibitor of Apoptosis in Tumor Exosomes
… Both protein and mRNA of the IAP Survivin, cIAP1, cIAP2 and XIAP are released into the extracellular space by not only the pancreatic cancer cell line PANC-1, but also from other cancer and non-cancer cell lines. IAP release may play an important role in pancreatic cancer’s lack of response …
-
Characterization of a Small Molecule Smac Mimetic's Role in Inducing Apoptosis in Human Cancer Cells
… the target of Smac mimetic to be XIAP, cIAP1, and cIAP2 in both Smac mimetic induced and TNF/Smac mimetic induced apoptosis. Moreover, we were able to mimic the Smac mimetic effect by triple knockdown experiments of IAPs in TNF induced cell death. Furthermore, we identified the target of …