Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"cGMP-Dependent Protein Kinase"”.
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cGMP -Dependent Protein Kinase, Behavioral Plasticity, and Foraging in Honey Bees and Fruit Flies
… phenotype that is affected by a gene encoding a cGMP-dependent protein kinase (PKG, foraging). I accomplish this by using a traditional genetic model---the fruit fly, Drosophila melanogaster , and a traditional behavioral model---the honey bee, Apis mellifera. Variation in the for gene results in …
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Design, synthesis, and structure-activity relationship studies of dual Plasmodium falciparum phosphatidylinositol 4-kinase and cGMP-dependent protein kinase inhibitors
… efforts. Considering the success of human kinase inhibitors as anti-cancer drugs and the identification of Plasmodium kinases as promising targets for malaria chemotherapy, this study aimed to optimize anti-plasmodium phosphatidylinositol 4-kinase (PI4K) and the cGMP-dependent protein …
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The roles of nitric oxide,cGMP, and cGMP-dependent protein kinase in generation and modulation of circadian rhythms by the suprachiasmatic nucleus
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Interaction between Adrenergic and Nitric Oxide-releasing Nerves in Cerebral Arteries
… in part to a decline in the expression of nNOS protein.</p> <p>The mechanism by which NO modulates adrenergic nerve function has been proposed to involve a cascade of reactions leading to the mobilization of intracellular free calcium within adrenergic nerve terminals. Recall that the release of …
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PATHOGENIC ROLE OF PHOSPHODIESTERASE TYPE 5 UPREGULATION IN CARDIAC ISCHEMIA/REPERFUSION INJURY
… Expression and activity of PDE5, pPDE5, and cGMP-dependent protein kinase (PKG) were measured by Western blots and spectrophotometric assay. The results show that ischemia and I/R significantly increased expression of PDE5. H2O2 had no effect on PDE5 expression and activity but significantly …
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Defining Molecular Mechanism of Egress in Cryptosporidium
… Here we tested the hypothesis that calcium-dependent protein kinase 5 (CDPK5), subtilisin-like serine protease (SUB1), and cGMP-dependent protein kinase G (PKG) are essential for egress of Cryptosporidium parvum merozoites from host cells. Our results demonstrated that PKG and SUB1 are …
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Investigation of the SCN 2.2 Cell Line as a Model of the Central Mammalian Circadian Pacemaker
… These rhythms were blocked by inhibition of cGMP-dependent protein kinase (PKG), a known element of several circadian regulatory pathways. As with the SCN, synchronized SCN 2.2 cultures expressed a gated response to glutamate stimulus in both induction of ser-133 phosphorylated cAMP response …
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Ischemic Preconditioning Protects Adult Rat Cardiomyocytes Against Necrosis but not Apoptosis, via Activation of PKG
The role of cyclic guanosine monophosphate (cGMP) dependent protein kinase (PKG) in necrotic and apoptotic pathways of many cell types is well established; however its role in the ischemic preconditioning (IPC) of cardiomyocytes is not clearly defined. In the current study, we assessed the …
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Role of Protein Kinase G in Regulating Vascular Tone in Hypoxic Ovine Cerebral Arteries
… the role of cyclic guanidine monophosphate (cGMP)-dependent protein kinase (PKG) has been shown to be the main mediator of NO-induced vasorelaxation. Less well understood is the behavior of this pathway in conditions of long term hypoxia (LTH). It was later shown that LTH attenuates the …
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Characterisation of Guanylin and Uroguanylin in the Digestive System
… of the intracellular secondary messenger cGMP. Subsequently cGMP stimulates both cGMP- dependent protein kinase II (PKGII) and protein kinase A (PKA). Both PKGII and PKA phosphorylate the cystic fibrosis transmembrane conductance regulator (CFTR), leading to an efflux of chloride in the …
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Design of Selective Plasmodium falciparum Kinase Inhibitors using Computer-Aided Drug Discovery
… campaign is based on the following Plasmodium kinases: Plasmodium falciparum phosphatidylinositol 4-kinase (PfPI4K) and Plasmodium falciparum cyclic guanosine monophosphate (cGMP)-dependent Protein Kinase (PfPKG). The aim of this study was to use computer-aided drug design (CADD) methods to …