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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 115 for “"cGMP"”.
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The roles of nitric oxide,cGMP, and cGMP-dependent protein kinase in generation and modulation of circadian rhythms by the suprachiasmatic nucleus
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Identifizierung und Funktion von Effektorproteinen der NO/cGMP Signalkaskade
… die lösliche Guanylylzyklase und führen über den cGMP/cGMP-Kinase abhängigen Signalweg zur Erschlaffung der glatten Muskulatur. Wie die Kinase dieses Signal vermittelt ist noch weitgehend unklar, wobei schon einige Substrate der cGMP-Kinase I bekannt sind. In der Mikrosomenfraktion glatter Muskeln …
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cGMP Training Programs: Understanding the Effects of Cognitive Load
… The current Good Manufacturing Practices (cGMP) regulations require that training be conducted on cGMPs on a periodic basis. However, the cGMPs are complex, comprehensive and tedious and the training on cGMPs is notoriously boring. Cognitive Load Theory has helped to improve instructional …
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Analyse Gewebe-spezifischer Deletionen der cGMP-abhängigen Proteinkinase Typ I in Mäusen
… dass NO die Synthese des "second Messengers" cGMP bewirkt, welcher die cGMP-abh?xE4;ngige Proteinkinase Typ I (cGKI) aktiviert. Um die in vivo-Funktion der cGKI aufzukl?xE4;ren, wurden bereits konventionelle cGKI Knockout M?xE4;use generiert und analysiert. Da diese Nullmutanten einen …
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Molecular Characterisation of the Brassinosteroid, Phytosulfokine and cGMP-dependent Responses in Arabidopsis thaliana
… that these molecules can convert GTP to cGMP in vitro. Secondly, we show that exogenous application of both Phytosulfokine and Brassinosteroid increase changes of intracellular cGMP levels in Arabidopsis mesophyll protoplast demonstrating that these molecules have GC activity in vivo and …
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Modulation of innate immunity by the cGMP signalling pathway in the drosophila malpighian tubule
… effect is mediated through activation of the cGMP signalling pathway, via interaction with one of its upstream components, soluble guanylate cyclase (sGC), the main intracellular target for NO (Marletta and Spiering 2003). Therefore, the aim of this study was to determine the potential role of …
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cGMP -Dependent Protein Kinase, Behavioral Plasticity, and Foraging in Honey Bees and Fruit Flies
… phenotype that is affected by a gene encoding a cGMP-dependent protein kinase (PKG, foraging). I accomplish this by using a traditional genetic model---the fruit fly, Drosophila melanogaster , and a traditional behavioral model---the honey bee, Apis mellifera. Variation in the for gene results in …
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Die Regulation aktivierender und hemmender Signalwege in humanen neutrophilen Granulozyten durch cAMP- und cGMP-erhöhende Vasodilatatoren
… charakterisiertes Substrat der cAMP-PK und der cGMP-PK. Phosphorylierungsversuche mit cAMP-erhöhenden Substanzen ergaben eine rasche, reversible Phosphorylierung dieses Proteins an Ser-157 und Ser-239 in intakten humanen Neutrophilen Granulozyten. Versuche mit cGMP-erhöhenden Substanzen zeigten …
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Genetic analysis of cGMP-dependent chemosensory signal transduction pathways in the detection of bacterial metabolites by C. elegans
… genetic approaches, we identified several cGMP-related components that are essential for the pathway, including a subunit for cyclic nucleotide-gated channels, CNG-2, and a cGMP-dependent kinase, EGL-4. We show that while CNG-2 induces daf-7 expression in a calcium-dependent manner, EGL-4 …
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Design, synthesis, and structure-activity relationship studies of dual Plasmodium falciparum phosphatidylinositol 4-kinase and cGMP-dependent protein kinase inhibitors
… phosphatidylinositol 4-kinase (PI4K) and the cGMP-dependent protein kinase (PKG) inhibitors, based on two distinct chemotypes. Plasmodium PI4K and PKG are validated targets, each with the potential to deliver pan-stage active compounds with potentially moderate to low risk of resistance. Part …
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Regulation of mammalian photoreceptor phosphodiesterase (PDE) by its noncatalytic GAF domains and its two small subunits, gamma and delta
<p>cGMP phosphodiesterase (PDE) is the central effector of visual transduction in retinal rod photoreceptors. The overall goal of this work was to investigate the possible regulatory mechanisms of PDE in mammalian rod photoreceptors by its noncatalytic cGMP binding sites on the PDE catalytic dimer …
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Biochemische Charakterisierung des ADP-Rezeptors P2Y12 und pharmakologische Therapiekontrolle von Thrombozytenfunktionshemmern
Die Bedeutung der cAMP- und cGMP-abhängigen Proteinkinase für die Hemmung der Plättchenaktivierung und -aggregation ist gut beschrieben. Zahlreiche fundamentale Plättchenantworten wie die Erhöhung der intrazellulären Calciumkonzentration, die Exposition von Adhäsionsrezeptoren und die …
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Fluid retention in congestive heart failure-the role of natriuretic peptides and arginine vasopressin
… ANF measurement. Urine was collected for cAMP, cGMP and creatinine measurement. In vitro cGMP accumulation studies were done in inner medullary duct cells (IMCD) cells upon stimulation by ANF, and in glomeruli upon stimulation by ANF, BNP and CNP. cAMP accumulation studies were done in IMCD …
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Untersuchung der funktionellen Interaktion zwischen der sarkolemmalen Calcium-ATPase und der neuronalen NO-Synthase
… zeigen ex vivo eine signifikant höhere cGMP-Konzentration als wildtypische Rattenherzen. Das Ergebnis kann in mit PMCA4b und nNOS transfizierten wildtypischen und PMCA4b-überexprimierenden Kardiomyozyten bestätigt werden. Je höher die PMCA-Konzentration während der Transfektion ist, …
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The role of reactive nitrogen species and aged garlic extract on platelet function
… nucleotide, cyclic guanosine monophosphate (cGMP) is currently unknown. The aims therefore of this project are to identify the effect of AGE upon platelet cGMP, as well as associated signaling molecules including nitric oxide (NO) and cAMP.It was found that the NO donor …
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The effects of the tubulin-binding drug, colchicine, on the electrophysiological aspects of phototransduction in toad rod photoreceptors
… guanosine monophosphate, cGMP (the physiologic activator of the light-sensitive conductance, g$\sb{\rm h\nu}$), either physiologically or exogenously. It was concluded that colchicine blocks the light-sensitive current, probably by lowering (cGMP) $\sb{\rm i}$ rather than …
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An investigation into the synaptic conditions and celluar mechanisms underlying cerebellar synaptic plasticity
… (NO) donor, a cyclic guanosine monophosphate (cGMP) analogue or a phosphodiesterase (PDE) type V inhibitor to prevent cGMP breakdown paired with IF stimulation produced an acute depression, Raised frequency (RF) molecular layer stimulation produced a slowly emerging LTD of N2 in sagittal slices …
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