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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"cGAS-STING"”.
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Regulation of the cGAS-STING Pathway in Health and Disease
Pages v-xiii are misnumbered as pages vi-xiv.
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The Role of the cGAS-STING Pathway in Cancer and Autoimmunity
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
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Regulation of the cGAS-STING Pathway: Non-Agonist Activation and Cellular Trafficking
The cGAS-STING pathway in the innate immune system plays an important role in infection and cancer. Exogenous or endogenous DNA and cyclic dinucleotides acutely activate cGAS-STING, leading to type I interferon (IFN) signaling. STING-mediated IFN signaling is dynamically regulated by STING …
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STING safeguards epithelial genome integrity and protects from carcinogenesis via mitotic checkpoint control
The cGAS-STING pathway is widely recognized as a central mediator of innate immune responses to cytosolic DNA. However, whether cGAS-STING directly coordinates DNA damage response in non-immune cells and thereby contributes to cell-intrinsic prevention of oncogenesis is not known. The present work …
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The Role of STING-Mediated Neuroinflammation in Traumatic Brain Injury
… Synthase- Stimulator of Interferon Genes (cGAS-STING) pathway is one of the primary methods of producing Type I IFNs; therefore, this work sought to evaluate the role of the cGAS-STING pathway in a murine controlled cortical impact (CCI) model of TBI. Using cGAS knockout (KO) or STING KO …
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SMYD3: A PLAYER IN STEMNESS AND CHROMOSOME INSTABILITY IN TRIPLE NEGATIVE BREAST CANCER
… possibile coinvolgimento di SMYD3 nel pathway di cGAS-STING. Le cellule cancerose sono caratterizzate da un alto livello di CIN, il quale porta al rilascio di DNA genomico nel citoplasma, che viene riconosciuto dal pathway di cGAS-STING, che viene a sua volta attivato nel suo ramo …
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The Mechanism of cGAMP Induced Antitumor Effect and Its Application in Treating Cancer and Antibody Generation
… yet most patients remain unresponsive to existing therapies. The cGAS-cGAMP-STING pathway, a notable target, primarily activates the innate immune system, inducing strong antitumor responses. Direct cGAMP delivery into tumors has demonstrated significant antitumor effects in vivo. Despite …
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Mechanisms of cytosolic DNA sensing and neuroinflammation in ataxia-telangiectasia
… cytosol, activating the cytosolic DNA sensing cGAS-STING pathway. Utilising genetic knockout of ATM or selective kinase inhibition in human microglial cell models, this thesis demonstrates that DNA damage associated with ATM deficiency drives chronic inflammation in a cGAS-STING-dependent …
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Investigating The Role of Abro1 In Dna Damage-Induced Immune Response
… been shown that genomic instability can trigger cGAS/STING pathway , inducing activation of the innate immune response and inflammatory gene expression through cGAS binding to cytoplasmic DNA or localizing to micronuclei in response to DNA damage. Here, I found that replication stress induced by …
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An examination of the role of IFI16 in detecting viral DNA in human immortalised keratinocytes
… of the DNA sensor cyclic GMP-AMP synthase (cGAS). cGAS produces the second messenger cyclic GMP-AMP (cGAMP) which binds to and activates the endoplasmic reticulum adapter STimulator of INterferon Genes (STING). Activated STING initiates transcription of the anti-viral cytokine interferon-b, …
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Disruption of Dna Polymerase Zeta Promotes An Innate Immune Response
… stress, can activate the cytosolic DNA sensor cGAS which promotes an interferon response with its signaling partner, STING. Knockdown of cGAS and STING in <em>Rev3l </em>KO MEFs significantly reduced expression of interferon-stimulated genes indicating that loss of pol ζ promotes activation of …
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Mechanism and Functions of STING-Induced Noncanonical Autophagy
The cGAS-STING pathway is a vital component of innate immunity. In addition to its well-established role in inducing proinflammatory cytokines, activation of the pathway also induces noncanonical autophagy. Despite an increasing body of research on STING-induced noncanonical autophagy, our …
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Dissecting the Role of ATRX in Soft Tissue Sarcoma Development and Therapeutic Response
… We find that Atrx deleted tumors have impaired cGAS-STING signaling, with accompanying sensitivity to the novel clinical therapy oncolytic herpesvirus. Translation of these results to patients with ATRX mutant cancers could enable genomically-guided cancer therapeutic approaches that improve …
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Counteracting Neuroinvasive RNA Viruses: Antiviral and Immune Modulation Strategies Against SARS-CoV-2 and VEEV
… during VEEV infection, but little is known about cGAS-STING involvement. The rationale in pursuing this pathway is mechanism studies can lead to discovery of possible targets of therapeutic intervention. cGAS-STING signaling has been proposed to regulate or activate in response to VEEV infection …
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MECHANO-CHEMICAL FEEDBACK VIA CONTACT PERCOLATION REGULATES PHASE TRANSITION AND TRANSCRIPTIONAL STATE IN HETEROGENEOUS BREAST CANCER
… and triggers an inflammatory gene response via cGAS/STING pathway and the acquisition of malignant traits. While prior studies used genetically homogeneous models, BC exhibits mechanical and genetic heterogeneity, which role in PT and BC progression is poorly understood. Here, we reveal that …
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Ancient Immune Systems: Sensing and Signaling in Bacterial-Phage Conflict
… Since CBASS and Thoeris are orthologous to cGAS-STING and Toll-like receptors (TLRs), respectively, in mammalian innate immunity, these findings highlight conserved mechanisms for the activation of antiviral defense pathways across evolutionary domains [1].</p>
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Engineering Intratumoral Cytokine Therapies for Cancer
Immunotherapies enable effective, long-lasting anti-tumor immunity for some cancer patients. Cytokines are key signaling proteins that help activate and sustain critical immune cells during this process. Unfortunately, traditional cytokine therapies suffer from low efficacy and high systemic …
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Interactions Between Host Cells And Merkel Cell Polyomavirus In The Context Of Infection And In Merkel Cell Carcinoma
… This innate gene induction was mediated by the cGAS-STING and NF-κB pathways and has the potential to restrict MCPyV replication. We also screened natural compounds for their activity against the MCPyV promoter and for specific cytotoxicity in MCPyV-positive MCC cell lines. We determined the …
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Toward the Rational Design of Better Antivirals: The Development of cGAMP as an HIV-1 Anti-Retroviral and the Genetic Surveillance of WNV Evolution
… mechanisms to evade immune detection by the cGAS-STING cytosolic DNA sensing pathway. A small cyclic di-nucleotide, cGAMP, activates the same pathway by directly binding STING. Treatment with cGAMP, delivered by ultra-pH sensitive nanoparticles or by liposomes, in human peripheral blood …
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Harnessing DNA nanoarchitecture to overcome immunoevasion in cancer
… of activating the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway; and (2) deliver epigenetic modifiers to reprogram immunosuppressive cues in tumor cells. This solution exploits the modularity, programmability, and ease of control over DNA synthesis to generate …
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