Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"cFLIP"”.
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Characterization of the anti-type I interferon effects of the cellular flice-like inhibitory protein (CFLIP)
The cellular FLICE-like inhibitory protein (cFLIP) is well known as a major immunomodulatory protein. Various works have described its role in major cellular pathways such as apoptosis, autophagy, necroptosis, NF-KB regulation and more recently, modulation of interferon responses. Interferon alpha …
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Direct Regulation of Apoptosis By Linear Ubiqutin Chain Assembly Complex (Lubac) and Feedback Regulation of Lubac Function By Caspases
… cellular FLICE-like inhibitory protein (cFLIP). Finally, I determined the negative feedback to regulate function of LUBAC from apoptosis. Effector caspases induce RNF31 cleavage in apoptotic condition, which suppresses its role in NF-kB activation. This study is the first to demonstrate …
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The Role of Alternative Splicing and Alternative Polyadenylation in Regulating Activated T cell Biology
… may regulate T cell survival by controlling cFLIP levels through promoting proximal PAS usage within the 3'UTR tail. In summary, this dissertation demonstrates broad alternative splicing and polyadenylation changes are fine-tuned to specific T cell stimuli and exert biological impact on cell …
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In vivo and in vitro studies of immunodeficiency in Ataxia-telangiectasia
… for a role of ATM in regulating either CD95 or cFLIP expression. Consistent with this was the increased sensitivity to CD95-mediated apoptosis of T cell prolymphocytic leukaemia (T-PLL) cells. The cause of the tumour is primary loss of ATM activity (either germline loss similar to A-T LCLs or …
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Papel de YAP/TAZ en la respuesta de células tumorales a estímulos activadores de receptores de TRAIL
… oligomerización TRAIL-R2, y mantiene niveles de cFLIP suficientes para dificultar la activación de la caspasa-8; esto favorece la supervivencia de la célula tumoral a la UPR. Las células tumorales también deben sobrevivir a la escasez de aminoácidos. La glutamina es el primer aminoácido en …
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Papel del metabolismo de la glutamina en el control de la sensibilidad a trail de células tumorales de mama.
… demuestran que la reducción de los niveles de cFLIP es el evento responsable de la marcada sensibilización de las células TNBC a la apoptosis inducida por TRAIL tras privación de glutamina. Además, nuestros resultados demuestran que la inhibición farmacológica de las transaminasas aumenta los …