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Showing 1 to 12 of 12 for “"cDNA array"”.
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Entwicklung und Evaluierung eines Verfahrens zur Genexpressionsanalyse bei individuellen präimplantatorischen Säugerembryonen über die cDNA-Array-Technologie
… präimplantatorischer Embryonalstadien über die cDNA-Array-Technologie ermöglicht. Dazu wurde die Strategie gewählt, zwei bereits etablierte Amplifikationsverfahren, Polymerasekettenreaktion und In vitro-Transkription, zu kombinieren, um so synergistische Effekte beider Verfahren zu nutzen. Die …
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The Quantitative Assessment of Osteoinductivity of Human Demineralized Bone Matrix and cDNA Array Analysis of Osteogenic Differentiation in Human Periosteal Cells
… potential of human DBM and the use of cDNA gene expression array technology for examining gene expression profiles during osteoblast differentiation in human periosteal cells.</p> <p>BMP-4 is one of the most osteoinductive factors and has been investigated for clinical applications. For …
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Functional genomics of nodulins in the model legume Lotus japonicus
… functionally characterise them. An existing 5.6K cDNA array (Colebatch et al., 2004) was extended to produce the 9.6K LjNEST array, while a second array, the 11.6K LjKDRI array, was also produced. Furthermore, the protocol for array hybridisation was substantially improved (Ott et al., in press). …
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Vitamin E : elucidation of the mechanism of side chain degradation and gene regulatory functions
… liver RNA was prepared for hybridization using cDNA array and oligonucleotide array technology. A significant change in gene expression was observed by alpha-tocopherol but not by gamma-tocotrienol and only using the oligonucleotide array but not using the cDNA array. The latter effect is most …
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The Role Of The Sparc Acidic Domain And Egf-Like Module In Glioma Migration, Invasion, And Signaling
… confirm, at the protein level, our previous cDNA array results, that SPARC increases expression of the matrix metalloproteases (MMPs) MT1-MMP and MMP-2. We also demonstrate that SPARC increases MMP-2 activation and the secretion and processing of galectin-3, a known target of MMPs. To …
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Comparative Genome Analysis of Three Brucella spp. and a Data Model for Automated Multiple Genome Comparison
… to be used in design of a discriminatory genomic cDNA array for comparative functional genomics experiments. Comparisons were made of coding regions from the public, annotated sequence of B. melitensis (GenBank) to the annotated sequence of B. suis (TIGR) and to the newly-sequenced B. abortus …
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Recombinant Equine Interleukin-1 Induced Models of Equine Joint Disease
… modeling of early joint disease. A customized cDNA array was used to profile changes in mRNA levels resulting from EqIL-1 treatments of cultured articular cartilage chondrocytes. EqIL-1a induced elevated mRNA levels corresponding to six genes after 1 hour relative to media control chondrocytes …
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Metadherin Functions As A Laminin Receptor That Is Essential For Metastasis and Is Associated With Poor Survival In Osteosarcoma
… lesions of osteosarcoma, two tissue microarrays containing patient-derived primary and metastatic tumor specimens were examined by immunohistochemical staining with anti-MTDH antibody. We also examined MTDH in a cDNA array expression database made from pretreatment diagnostic biopsies of …
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Cyclooxygenase-2 and prostaglandins in human endometrial function
… in regulation of endometrial angiogenesis, cDNA array technology was employed to identify differentially expressed genes that may be involved in vascular function. Using this technique, a total of 81 genes were differentially regulated including cathepsin D. Cathepsin D mRNA and protein …
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Untersuchungen zur Funktion der Rezeptortyrosinkinase FGFR4 in der Tumorentwicklung
… Wildtyprezeptor exprimierten. Daneben ergab die cDNA Array Analyse in den oben genannten Brustkrebszelllininen unterschiedliche Expressionsstärken für eine Reihe von Genen, die in der Tumorentwicklung eine bedeutende Rolle spielen. Des weiteren gelang es mit einem Fusionsprotein zwischen der …
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Isolation and functional analysis of differentially expressed genes in human prostate cancer
… von IGFBP-3 mittels eines cancer profiling arrays in folgenden Karzinomen bestimmt: Nieren-, Lungen-, Mastdarm-, Dickdarm-, Magen und Schilddrüsenkrebs. Im Gegensatz dazu wurde eine Herunterregulierung in Brust-, Uterus- und Ovarialkrebs festgestellt. Diese Ergebnisse deuten auf eine …
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Autonome Parvoviren
… cellular gene expression. For this purpose, the cDNA array technique was used. It was previously shown that parvovirus H1 infection leads to the activation of caspase 3 and apoptotic cell death of the human monocytic U937 cell, in a way similar to the apoptotic cell death induced by TNFα. …