Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 4 of 4 for “"cDC1s"”.
-
Stat3 Inhibits Type I Interferon Signaling In Type I Conventional Dendritic Cells
… immunity and tolerance. Recently, type I cDCs (cDC1s) have been delineated as a distinct cDC subset, uniquely responsible for coordinating T cell-mediated immunity against pathogens and tumors. Although the importance of cDC1s is now well established, the mechanisms that regulate cDC1 function …
-
The Role and Regulation of Id2 In Dendritic Cells
… including the DC progenitor compartment and cDC1s. Therefore, we hypothesize TLR agonist signaling regulates Id2 induction, affecting both DC lineage development and the unique effector functions of pDCs and cDC1s. Herein, we found Id2 expression correlates with pDC maturation upon TLR …
-
Dendritic Cells Suppress Pathogen-Induced Inflammasome Activation to Prime Naïve T Cells
… T cells. Transcription factors IRF8 and IRF4, in cDC1s and cDC2s respectively, mediate this suppression of inflammasome activation by limiting the expression of inflammasome-associated genes. Additionally, overexpression of either of IRF4 or IRF8 is sufficient to inhibit inflammasome activation in …
-
Engineered Type 1 Conventional Dendritic Cell–Based Therapies for In Situ Cancer Immunization
… efficacy. Type 1 conventional dendritic cells (cDC1s) are dendritic cell subsets specialized for cross-presentation and CD8+ T cell activation and have shown promise in initiating inflammatory antitumor immunity while maintaining and activating precursor exhausted T cells. In this thesis, we …