Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 31 for “"cAMP-signaling"”.
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The G protein-coupled receptor GPR30 signalosome - A novel G protein-independent mechanism regulating cAMP signaling and receptor trafficking
… The aim of this thesis was to elucidate the signaling and membrane trafficking of GPR30 in addition to look for any binding partners. My primary findings were: (1) GPR30 constitutively internalizes without any need for ligand binding. (2) GPR30 associates with cytokeratin filaments (3) GPR30 …
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Testing Whether MRP4 (a cAMP Efflux Pump) and the Beta 2 Andrenergic Receptor (an Upstream Regulator of cAMP Signaling Pathways
… that can efflux the second-messenger, cAMP, from cells. MRP4 has a PDZ interacting motif at its carboxy terminal end through which it binds to scaffolding proteins NHERF1 and PDZK1. Previous studies have shown that PDZK1 serves as a scaffold physically coupling MRP4 with the cystic …
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Molecular Signaling and Agonist Discovery for GPR52
… work herein describes the investigation of GPR52 signaling mechanisms, molecular determinants for GPR52 activation, and discovery of biased GPR52 agonists. GPR52 was determined to couple to both Gs and Golf to increase cAMP signaling, with constitutive activity driven by Gs. GPR52 is co-expressed …
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Crosstalk Signaling Between cAMP and Calcium on the Leading Edge of Migrating Human Arterial Vascular Smooth Muscle Cells
… nucleotide phosphodiesterase, PDE1C, a dual cAMP/cGMP hydrolyzing PDE, is exclusively expressed by synthetic VSMCs and regulates their synthetic, migratory and proliferative actions, it may represent a valid synthetic VSMC specific therapeutic target. Store operated calcium entry (SOCE) …
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Effect of Melatonin on Differentiation of Human Mesenchymal Stem Cells and a Study on C-Terminal Domains of MT1 and MT2 Melatonin Receptors
… and desensitized receptors with respect to cAMP signaling, signifying two distinct mechanisms of melatonin's action. Unlike the parathyroid hormone which is administered in intermittent doses to increase bone mass, a continuous melatonin treatment may be effective in having an anabolic …
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Characterisation of cyclic adenosine monophosphate/protein kinase A signalling networks in blood platelets
… beyond the triggering of cyclic nucleotides signaling pathways. The aim of this study was to improve our understanding of platelet regulation by cAMP signaling networks.We observed differences in cAMP signaling depending on the agonists used. Using phosphorylation of PKA substrates as a …
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Regulation of glycogen phosphorylase genes in Dictyostelium discoideum
… gp-1 and gp-2 genes is regulated by exogenous cAMP. Exogenous cAMP enhances the level of gp-1 mRNA, apparently through a mechanism that requires intracellular cAMP signaling. Specific DNA sequence elements appear to be required for maximal vegetative and late developmental expression of gp-1. …
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CD151 Reinforces Vascular Stability by Balancing Endothelial Cell Adhesion and Cytoskeletal Tension
… intrinsic contraction by upregulating RhoA signaling and downregulating of Rac1 activity. CD151 balances RhoA and Rac1 activities and stabilizes the membrane-cytoskeleton connection. In the absence of CD151 expression, the inhibition of RhoA signaling axis enhances the diminished cell-cell …
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Role of an Adenylyl Cyclase Isoform in Alcohol's Effect on Cyclic AMP Regulated Gene Expression in Mammalian Cells
Research suggests that the cyclic AMP (cAMP) signaling pathway including CREB-CRE regulated expression of various genes is implicated in the predisposition to and development of alcoholism in humans. Alcohol also induces changes in inflammatory and immune responses; these changes increase the …
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Biologically Interpretable Representation Learning for Mechanistic Insights into Cancer Immunotherapy Resistance
… aligned with immune regulation, tumorintrinsic signaling, metabolism, and neuroimmune interactions. SHAP-based interpretation and pathway analysis highlight key resistance-associated programs, including immunosuppressive cytokine signaling, metabolic signaling, and neuroactive pathways such as …
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Adenylyl Cyclase 2 Selectively Regulates IL-6 Expression in Human Bronchial Smooth Muscle Cells
… the formation of the ubiquitous second messenger cAMP. AC isoforms differ in their tissue distribution, cellular localization, regulation, and protein interactions, and most cells express multiple isoforms. We hypothesized that cAMP produced by different AC isoforms regulates unique cellular …
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Sensory Primary Cilium is a Distinct Signaling Compartment
… of fluid-shear stress into intracellular signaling. Over recent years, studies in primary cilia have intensified after determining a causal relationship between dysfunctional primary cilia and cystic diseases. Along with its mechanosensory function, the primary cilium houses a variety of …
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Odor intensity learning in Drosophila
… been proposed that mainly relies on the known cAMP signaling pathway. Mushroom bodies (MB) have been shown to be necessary and sufficient for this type of memory, and the MB-model of odor learning and short-term memory was established. Yet, theoretically, based on the MB-model, flies should not …
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Regulation of synaptic function and plasticity by cyclin-dependent kinase 5
… synaptic plasticity. Loss of Cdk5 in the hippocampus disrupts the cAMP pathway due to increased phosphodiesterase proteins. This dysregulation of cAMP signaling can be attenuated by a phosphodiesterase inhibitor to restore levels of protein phosphorylation, synaptic plasticity, and memory. …
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Regulation of biochemical pathways involved in neurodegeneration
… by the prostaglandin EP2 receptor and the cAMP signaling cascade. Therefore, EP2 receptor antagonists may constitute an additional target for prevention of AD following brain injury.
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Protein Kinase A Regulates Hyphal Growth by Relieving the Interaction of MoSfl1 with the Cyc8-Tup1 Co-repressor in Magnaporthe oryzae
The cAMP-dependent protein kinase A (PKA) signal transduction pathway plays an important role in morphogenesis and virulence in plant pathogenic fungi. In the rice blast fungus Magnaporthe oryzae, it regulates surface recognition, appressorium turgor generation, and invasive growth. Two genes in M. …
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EPAC1 AS A THERAPEUTIC TARGET FOR PANCREATIC DUCTAL ADENOCARCINOMA
The recent discovery of a new family of cAMP sensor proteins, exchange protein activated by cAMP (EPAC), ushered in a new era in cAMP signaling. EPAC is composed of two main isoforms, EPAC1 and EPAC2, whose roles in mediating cAMP effects in various cellular contexts remains relatively unclear, and …
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Analysis of the Role of the Transcription Factor-C/ebpbeta in Implantation
… in response to serum and steroid hormone and cAMP signaling, respectively, my research uncovered that C/EBPbeta controls the G1/S transition of the proliferating HESCs by regulating the expression of specific cell cycle regulators such as cyclin E and E2F1. My studies, using a siRNA strategy, …
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Post-translational modifications regulate β2-Adrenoceptor signaling in cardiac myocytes
… cyclase-cyclic adenosine monophosphate (cAMP)-protein kinase A (PKA) signaling pathway. In the mammalian heart, increasing cAMP-PKA activity leads to phosphorylation of an array of proteins involved in increasing heart contractility and rate. β2AR also has a cardiac protective role …
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Analysis of the role of the transcription factor-C/EBPβ in implantation
… in response to serum and steroid hormone and cAMP signaling, respectively, my research uncovered that C/EBPβ controls the G1/S transition of the proliferating HESCs by regulating the expression of specific cell cycle regulators such as cyclin E and E2F1. My studies, using a siRNA strategy, …
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