Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"cAMP response element binding protein (CREB)"”.
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Untersuchungen zur Funktion von cAMP Response Element Binding Protein (CREB) und Activating Transcription Factor 1 (ATF1) während der Embryonalentwicklung der Maus
Die Transkriptionsfaktoren cAMP Response Element Binding Protein (CREB), cAMP Response Modulatory Protein (CREM) und Activating Transcription Factor 1 (ATF1) werden innerhalb der Leucinzipperproteine in der CREB/ATF-Unterfamilie zusammengefaßt. Verschiedene Hormone, Wachstumsfaktoren und …
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EPIGENETIC REGULATION OF MICROGLIAL PHOSPHATIDYLINOSITOL 3-KINASE PATHWAY INVOLVED IN SYNAPTIC PLASTICITY IN RODENTS
… expression, the phosphorylation of AKT and the cAMP response element binding protein (CREB) and ultimately brain-derived neurotrophic factor (BDNF) expression, shown to be involved in neuronal LTP. Microglial PI3K was also found to be post-translationally regulated through sumoylation. …
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THE EFFECT OF SKELETAL MUSCLE-SYNTHESIZED BDNF ON MOTOR NEURON SOMA SIZE AND BDNF PROTEIN ABUNDANCE
… signaling cascade that recruits dynein motor proteins for retrograde transport of the BDNF/TrkB endosome to the motor neuron soma. At the motor neuron soma, the BDNF/TrkB complex activates cyclic Adenosine Monophosphate (cAMP) response element binding protein (CREB), leading to transcriptional …
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Profiling the activity of GPR55 antagonists against recombinant and endogenous GPR55
… novel GPR55 antagonists on LPI-mediated GPR55 responses, in a HEK293 cell line stably expressing GPR55 (hGPR55-HEK293) and also in a prostate cancer cell line that expresses GPR55 endogenously at high levels (DU145). Antagonist effectiveness was also examined in a neuronal model of Alzheimer’s …
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Temporal evolution of intracellular signaling and gene expression following patterns of membrane depolarization in the pheochromocytoma cell line, PC 12
… pheochromocytoma (PC 12) cells. In response to chronic depolarization, cytoplasmic free Ca2+ ([Ca2+]i) levels increased transiently, then decreased to intermediate levels that were maintained for more than 90 minutes. Short pulses of depolarization, from 1 to 5 minutes in length, …
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Mrp4 Is a Crucial Regulator of Testosterone Biosynthesis
<p>The physiological role of multidrug resistance protein 4 (Mrp4) in the testes is unknown. It was discovered that Mrp4 is expressed primarily in mouse and human Leydig cells; however, there is no current evidence that Mrp4 regulates testosterone biosynthesis. The role of Mrp4 was investigated in …
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Characterization of Rapid Nongenomic Cortisol Signalling in Rainbow Trout Liver
… and nongenomic signalling pathways. The genomic response to cortisol is characterized by activation of the corticosteroid receptors, glucocorticoid receptor (GR) and mineralocorticoid receptor (MR), whereas the nongenomic cortisol response involves rapid changes to downstream second-messenger …
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Overexpression of Serum Response Factor in Astrocytes Improves Neuronal Plasticity in a Model of Fetal Alcohol Spectrum Disorders
… deprivation. PDE1 inhibition can increase cAMP and cGMP levels, activating transcription factors such as the cAMP response element binding protein (CREB) and the Serum response factor (SRF). SRF is important for many plasticity processes such as LTP, LTD, spine motility and axonal …
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Metabolic and endocrine adaptations to heat stress in lactating dairy cows
Heat stress (HS), a stress response in homeotherms mainly due to elevated ambient temperature and failure of effective heat dissipation, causes a substantial negative economic impact to livestock industry worldwide. Reduced feed intake, a typical phenomenon observed during HS, was thought to be the …
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Novel Mechanisms of Β-Adrenergic Signaling In Prostate Cancer Progression
… eventually leading to increased activation of cAMP response element-binding protein (CREB). Downstream targets of CREB activation in neuroendocrine differentiation as well as in neoangiogenesis are largely unknown, indicating that the underlying mechanisms of β-adrenergic signaling in prostate …
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Molecular mechanisms of radiation-induced brain injury
… transcription factors (e.g., activator protein-1 (AP-1),nuclear factor-κB (NF-κB), and cAMP response element-binding protein (CREB)) and overexpression of pro-inflammatory mediators (e.g., tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and monocyte chemoattractant protein-1 …
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Age-related impairments in memory and in cholinergic signaling due to reduced blood glucose responses to epinephrine
… indicates that increases in blood glucose in response to endogenous epinephrine release are important for regulating memory formation and durability. In old rats, glucose is less responsive to epinephrine and becomes severely depleted in the extracellular fluid of the hippocampus during a …
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The Addicted Phenotype: Protein Phosphorylation Status and Dopamine Receptor Responsiveness
Up-regulation of cAMP/PKA signaling by drugs of abuse may contribute to escalation and relapse, possibly by differentially altering dopamine receptor-responsiveness in the mesolimbic dopamine system. To investigate this hypothesis, our initial studies measured alterations in cAMP-dependent and …