Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"cAMP pathway"”.
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The regulation of the CAMP signalling pathway in the human pathogenic fungus, Paracoccidioides brasiliensis
… of a human host (Nemecek et al., 2006). The cAMP pathway controls this morphological transformation in several fungi (Borges-Walmsley and Walmsley, 2000; Kronstad et al., 1998). G proteins are guanine-nucleotide (GDP or GTP) binding proteins that are generally associated with the cytoplasmic …
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The Effects of Host-like Environmental Signals and Gene Expression on Capsule Growth in Cryptococcus neoformans
… (30°C or 37°C), CO<sub>2</sub> (room air or 5%), cAMP (0 mM or 20 mM), and pH buffer (HEPES/no HEPES). We explore the effects of exogenous cAMP at a range of concentrations and of deletions of cAMP pathway genes <em>PKR1</em>, <em>PDE1</em>, and <em>PDE2</em>. We present a computational framework …
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Progesterone control of human endometrial cells
… the ability to activate the protein kinase A/cAMP pathway, such as Prostaglandin E₂ (PGE₂) and relaxin, are potent inducers of decidualisation when administered alongside progesterone in endometrial stromal cells (ESCs) in vitro. Uterine Natural Killer (uNK) cells increase in number in …
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Regulation of synaptic function and plasticity by cyclin-dependent kinase 5
… synaptic plasticity. Loss of Cdk5 in the hippocampus disrupts the cAMP pathway due to increased phosphodiesterase proteins. This dysregulation of cAMP signaling can be attenuated by a phosphodiesterase inhibitor to restore levels of protein phosphorylation, synaptic plasticity, and memory. …
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Potassium channels for high-frequency action potential generation in GABAergic interneurons of Rat Hippocampus
… in orien-alveus (OA) interneurons in the hippocampal CA1 region, a major class of dendritic inhibitory interneuron. The main results are as follows. First, the macroscopic K+ current in OA interneurons consists mainly of a fast delayed rectifier (57 ± 5), a slow delayed rectifier (25 ± 6), and …
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Cyclic AMP and the Induction of Reactive Astrogliosis
… cyclase. Here I tested the hypothesis that a cAMP-mediated intracellular pathway is involved in eliciting forskolin-induced reactivity in F98 cells, and I attempted to elucidate that pathway using inhibitors of known cAMP-dependent downstream signaling molecules and fluorescent Ca+2 indicators …
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Exploring Synaptic Vesicle Exocytosis
… show that at each bouton in a cultured rat hippocampal neuron there are four primed vesicles per synapses, each of which has a 10% chance of fusing with the membrane in response to a stimulus. These values only represent averages; both Pv and n vary widely between neurons and between synapses …
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Investigating in vitro Alpha-Synuclein Aggregation of Parkinson's Disease
… was established, supplement elevated levels of cAMP to the neurons, generating cell death, alterations in cellular signalling, and evidence of the presence of cytoplasmic phosphorylated α-syn. Once this model was established, further investigation into its biological mechanism was explored, by …
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MOLECULAR MECHANISMS UNDERLYING CLINICAL BEHAVIOR OF NEUROENDOCRINE TUMORS: STUDY OF NEW POSSIBLE BIOMARKERS PREDICTABLE OF PHARMACOLOGICAL RESISTANCE AND TARGETS
… and β-arrestins DRD2-mediated signaling pathways in PitNETs and on somatostatin/cortistatin system in novel PanNENs cell models. Briefly, β-arrestin 2 has been highlighted as novel potential biomarker of pharmacological responsiveness to DAs, and that combined therapy with DAs avoids …
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Biphasic neurogenic vasodilatation in the bovine intraocular long posterior ciliary artery
… PKG and the soluble guanylate cyclase/cGMP/NO pathway had no effect on the second component of vasodilatation. 8.Furthermore, various K+ channel blockers, or inhibitors of the PKA/cAMP pathway did not inhibit the second component of neurogenic vasodilatation. Therefore, neither the identity of …