Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"c6 cells"”.
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Roles of the P2X7 receptor in C6 astroglioma: in vitro and in vivo studies
… studied and in this work, I have used the rat C6 glioma as an experimental model system to investigate expression and function of the P2X7R in vitro and in vivo. The in vitro study has examined expression of the P2X7R in C6 cells and the involvement of this receptor in mediating cell functional …
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The Role of a Membrane Androgen Receptron in the Brain
… ERK and Akt phosphorylation in rat glioma (C6) cells. The effect of DHT on the activation of these signaling pathways is AR dependent, since flutamide blocked this effect. In contrast to the intracellular receptor, we concluded that DHT-BSA (membrane impermeant form of DHT) binds to DHT …
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A Preclinical Model of Ionizing Radiation and TNF-alpha Gene Therapy for Cancer
… in an aggressive, rapidly growing glioma tumor (C6) model. Plasmid DNA is an attractive vector system for delivery of foreign genes into eukaryotic cells due to its advantages including low immunogenicity <em>in vivo</em>, lesser toxicity and relatively low cost. We have constructed a …
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The Unfolded Protein Response Increases Production of Pro-Angiogenic Factors by Tumor Cell Lines
<p>The rapid growth and proliferation of tumor cells will be limited at a stage when they encounter inadequate levels of oxygen and nutrient supply within the poorly vascularized tumor mass. These severe conditions negatively affect the proper folding of nascent proteins in the endoplasmic …
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The effect of heavy metals on differentiated neuronal and glial cells
… and morphology on differentiating N2a and C6 cells. Initial research revealed thimerosal, methylmercury and cadmium to be the most toxic compounds tested, in terms of their ability to inhibit the outgrowth of neurites in both cell lines at sub-lethal concentrations. Although cadmium …
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Zinc ion homeostasis in cellular physiology and experimental models of traumatic brain injury
… and differentiated rat pheochromocytoma (PC12) cells and in rat glioma (C6) cells. When PC12 cells proliferate, [Zn2+]i undergoes precisely controlled fluctuations with two peaks within one cell cycle. These results demonstrate that the already established requirement for zinc in the cell cycle …
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Glioma produced periostin attracts human neural stem cells
"Stem cells from various lineages have been well known for their migration tendency toward glioma and become attractive vehicles to deliver therapeutic genes to brain tumors. However, which factors and mechanisms in these processes are not yet known. In the present study, I aimed at identifying the …
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Einfluss des Tyrosinkinaseninhibitors PTK 787/ZK 222584 auf Vaskularisation und Wachstum intracerebraler Gliome der Ratte
… in einem Tiermodell. Verwendet wurden hierbei C6-Rattengliomzellen aus denen durch retrovirale Transfektion von VEGF cDNA in sense Richtung ein stark VEGF exprimierender Zellklon generiert wurde.
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Chitosan/Ellagic Acid Composite Materials for Local Cancer Therapy
… its biological properties against cancer cells including human WM115 melanoma, human U87 glioblastoma, and rat C6 glioma cells <em>in vitro</em> and<em>in vivo</em>.</p> <p> In this study, a natural chitosan polymer was employed as a drug vehicle and ellagic acid (EA), a naturally …