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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 20 of 33 for “"c5a"”.

  1. The Role of The C5A Receptor In Host Defense Against Listeria Monocytogenes

    Calame, Daniel2014

    … it is unknown how its cleavage fragment C5a participates. Here we show in a model of systemic Lm<em> </em>infection that the C5a receptor is essential for host defense. C5aR-/- mice have reduced survival and increased bacterial burden in the liver and spleen in comparison to WT mice. …

    uthsc Repository record

  2. Measurement and mechanisms of complement-induced neutrophil dysfunction

    Wood, Alexander James TelferUniversity of Cambridge2019

    … factors are influenced by the complement protein C5a, released by unbridled activation of the complement system during critical illness. C5a suppresses antimicrobial functions of key immune cells, in particular the neutrophil, and this suppression has been shown to be associated with poorer …

    cambridge Repository record

  3. The role of anaphylatoxins in asthma and airway remodelling

    Khan, NazminKing's College London2012

    C3a and C5a anaphylatoxins are proinflammatory polypeptides released during complement activation. They exert their biological functions by interacting with the G protein-coupled receptors, C3aR and C5aR respectively. Activation of the complement system has been implicated in the pathogenesis of …

    kings Repository record

  4. ROLE OF P50 NF-KB IN MACROPHAGE MIGRATION

    TOTARO, MARIA GRAZIAUniversità degli Studi di Milano2010

    … their capacity to respond to the chemotactic C5a complement factor, in terms of both cell migration and ERK1/2 phosphorylation. In contrast, LPS-tolerant macrophages did not respond to the chemokines CCL2 and CCL5. By using the air pouch model in mice treated systemically with LPS (in vivo …

    milano Repository record

  5. Cervical Remodeling/ripening At Term And Preterm Delivery: The Same Mechanism Initiated By Different Mediators And Different Effector Cells

    Gonzalez Velez, Juan Miguel2014

    … infiltration and increased serum C3adesArg and C5adesArg levels were observed in both models when compared to gestational age matched controls. A significant increase in collagen degradation, matrix metalloproteinase 9 (MMP-9) activity and tissue distensibility was observed in the cervix in both …

    wayne-thes Repository record

  6. THE ABSENCE OF C3AR AND C5AR SIGNAL TRANSDUCTION PROMOTES T REGULATORY CELL DIFFERENTIATION AND REGULATES IMMUNOLOGIC TOLERANCE

    Strainic, Michael George, JrCase Western Reserve University School of Graduate Studies2013

    Here, we demonstrate that when C3aR and C5aR signals are not transduced into CD4+ T cells, PI-3K¿-AKT-mTOR signaling ceases, PKA activation increases, auto-inductive TGF-ß1 signaling initiates, and CD4+ T cells become Foxp3+ T regulatory cells (iTregs). Endogenous TGF-ß1 suppresses C3aR and C5aR …

    ohiolink Repository record

  7. Sphingosine-1-phosphate in mast cell-mediated allergic responses

    Price, Megan2016

    … (MCTC), also express CD88, the receptor for C5a, and are activated by anaphylatoxin C5a and the secretagogue compound 48/80. S1P induced release of IL-6, a cytokine known to promote development of functionally mature MCTC, from cord blood cultures containing adherent macrophages, and from …

    vcu Repository record

  8. Mapping the microbiota in hidradenitis suppurativa

    McCarthy, SiobhánUniversity College Cork2022

    … (CALPROLAB™ Calprotectin ELISA (HRP). Complement C5a levels were assessed using enzyme-linked immunosorbent assay (Abcam ab193695 Complement C5a Human ELISA Kit). Pain was widely reported in 134 responders to the visual analog scale questionnaire. 82.1% reported some level of pain and 35.8% …

    cork Repository record

  9. Analysis of the molecular interplay between Streptococcus pyogenes and its human host

    Johansson, BjörnDepartment of Clinical Sciences, Lund University2006

    … its important virulence factors, M1 protein and C5a peptidase, when exposed to plasma. The function of modified M1 protein and C5a peptidase is not yet elucidated but is suggested to have important implications for the pathogenicity of S. pyogenes. Opsonizing IgG recognizes and mediates the …

    lund Repository record

  10. Ligand induzierte Phosphorylierung des Chemokin Rezeptors CCR5: strukturelle Analyse und Funktion

    Hüttenrauch, Friederike2012

    … neben Homodimeren auch Heterodimere mit dem C5a Rezeptor (C5aR) und zu einem geringeren Maße mit dem Angiotensin Rezeptor II Typ 1a (AT1aR). Durch Coexpression von CCR5 mit C5aR oder AT1aR konnte eine signifikante CCR5-Cointernalisierung nach heterologer C5a-Stimulation beobachtet werden, die …

    goettingen Repository record

  11. Interaction Between the Metalloprotease ADAMTS-13 and the Proteins of the Alternative Pathway of the Complement System

    Bettoni, SerenaThe Open University2017

    … formation of the terminal complement products, C5a and C5b-9. Finally, this work documented that in condition of ADAMTS13 deficiency, VWF-mediated formation of terminal complement products, particularly C5a, alters the endothelial anti-thrombogenic properties and induces microvascular thrombosis …

    the-open-u Repository record

  12. Complement evasion strategies of human pathogens - the evolutionary arms race

    Jusko, MonikaProtein Chemistry, Lund University2014

    … C5 to release biologically active anaphylatoxins C5a, activity of which has been largely implicated in pathogenesis of periodontitis. Further, we showed that another important periopathogen, Prevotella intermedia, acquires resistance towards complement by binding complement inhibitor found in …

    lund Repository record

  13. Effekte von oxidativem Stress auf humane retinale Pigmentepithelzellen und deren Komplementaktivierung

    Zimmerling, RomyUniversität Leipzig

    … zunehmender Freisetzung der Komplementkomponente C5a reagieren. Diese Ergebnisse erlauben den Schluss, dass oxidativer Stress des RPE eine Komplementaktivierung begünstigt, die ihrerseits den zytolytischen Untergang von RPE-Zellen vorantreibt. Sowohl antioxidativ wirksame als auch …

    qucosa-diss

  14. The role of complement FH and apoE interactions in the regulation of Aβ1-42 and C1q-mediated complement activation

    Hyypiä, MareenaHelsingin yliopisto2023

    … activation, the subsequent formation of C5a and activation of C5a receptor (C5aR) expressed on Human embryonic kidney (HEK) 293 cells. The presence of all apoE isoforms on Aβ1-42/C1q complexes led to reduced C5aR activation. Surprisingly, however, the reduction was the largest with apoE4, …

    helsinki Repository record

  15. Staphylococcus aureus virulence factors dictate host signaling pathways and immune responses

    Ortiz Marty, Rebecca JosefinaVirginia Tech2011

    … chemotaxis. We hypothesized that CHIPS inhibited C5a receptor (C5aR) signaling. Monocytes pretreated with CHIPS did not inhibit C5aR signaling. Nevertheless, signaling pathways can reduce PMN function in models such as glucocorticoid treatment. Immunosuppressive effects of glucocorticoids on PMN …

    vt Repository record

  16. On the induction of inflammatory reactions by Streptococcus pyogenes

    Påhlman, LisaLund University, Faculty of Medicine, Institution for Clinical Sciences Lund2007

    … by cleaving inflammatory mediators such as C5a, fibrinopeptides and bradykinin. Here we find that TAFI binds to Streptococcal collagen-like surface protein A and B on S. pyogenes. These bacteria can also recruit the two TAFI activators thrombin and plasmin to the bacterial surface, leading …

    lund Repository record

  17. The regulation of allergic airway disease by type V collagen-induced tolerance

    Lott, Jeremy M.2013

    … Bronchoalveolar lavage levels of C3a¸ C5a and OVA-specific IgE were measured; and immunohistochemistry utilized to detect expression of complement regulatory proteins, expression, CD46/Crry and CD55, in lung tissue. Results: Compared to normal subjects, anti-col(V) antibodies were …

    iupui Repository record

  18. Cardioprotective treatment strategies

    vanderPals, JesperDepartment of Cardiology, Clinical sciences, Lund University2011

    … the receptor to the activated complement factor C5a. Hypothermia has been shown to suppress the development of I/R injury. In this thesis, the cardioprotective effects of ADC-1004 (paper I), apyrase (paper II) and hy- pothermia (paper III) were investigated. The effects of hypothermia on coronary …

    lund Repository record

  19. The effect of RAN inhibition on human colorectal cancer cells (CRC)

    Elrewey, Hussein A.S.University of Bradford2020

    … an effect on immune response by down regulating C5a, IL-1ß and IL-1α analysed at mRNA level. When treated with MBZ, the migration, invasion and colony formation abilities of HCT-116 K-Ras Mt., DLD-1 K-Ras Mt. and HCT-116 Pten-/- were significantly reduced compared to a control treated cell line. …

    bradford Repository record

  20. Immune Modulation of The Mycobacterium Tuberculosis Granulomatous Response

    Welsh, Kerry J2011

    … of the granulomatous response, complement factor C5a generates granuloma cohesiveness, and IL-6 is necessary for maintenance of an established granulomatous responses. Studies were next performed to determine the ability of lactoferrin to modulate the immune response and pathology to mycobacterial …

    uthsc Repository record

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