Global ETD Search
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Showing 1 to 2 of 2 for “"c-myc translocation"”.
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The Role of Activation-Induced Cytidine Deaminase in Antibody Diversification and B Cell Malignancies
… Aberrant AID activity, however, can lead to c-myc/IgH chromosomal translocations and ultimately to B cell lymphomas and plasmocytomas in mice. Such translocations can also be detected in B cells stimulated to switch in vitro. I showed that switching B cells also upregulate Rae-1, a ligand for …
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Role of AID and microRNA-155 in c-myc-IgH Translocations
<p>Chromosome translocations between oncogenes and the immunoglobulin (Ig) region spanning the variable (V), diversity (D) and joining (J) genes (Ig V-JH region) are found in a number of mature B cell lymphomas in humans and mice. The breakpoints are frequently adjacent to the recombination signal …