Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 159 for “"c-myc"”.
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Regulation von Teilungswahrscheinlichkeit und Zellzyklusdauer durch das Onkoprotein c-Myc
… die Rolle des onkogenen Transkriptionsfaktors c-Myc für eine schnelle Zellzyklusprogression untersucht. Der Stand der Forschung zu Beginn der Arbeit legte nahe, dass ohne die Expression von c-Myc eine Zelle nur verzögert den Teilungszyklus durchlaufen kann (Mateyak et al., 1997). Mit Hilfe eines …
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Role of AID and microRNA-155 in c-myc-IgH Translocations
… SHM. To determine whether SHM might induce c-myc to Ig V-JH translocations, we searched for such events in both IL6 transgenic (IL6 tg) and AID-/- IL6 tg mice. Our experiments demonstrate that AID is required for c-myc to Ig V-JH translocations induced by IL6. We also investigated the …
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Investigating the role of mRNA capping enzyme in C-MYC function
C-MYC is a transcription factor and a potent driver of many human cancers. In addition to regulating transcription, C-MYC promotes formation of the mRNA cap which is important for transcript maturation and translation. However, the mechanistic details of C-MYC-dependent mRNA capping are not fully …
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The c-Myc/TBX3/nucleolin/Hsc70 signalling axis in breast cancer
… oncogenic transcription factor c-Myc has been widely reported in breast cancer progression and c-Myc-driven pathways are elevated in aggressive drug resistant breast cancer cells and tumours. Our laboratory has previously shown that c-Myc directly binds and activates the TBX3 …
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INTERACTION OF PTEN DELETION AND C-MYC GAIN IN PROSTATE CANCER PROGRESSION
Prostate cancer is of significant public health importance since it is the most common non-cutaneous cancer and the second leading cause of cancer death among men in the United States. While the majority of prostate cancer patients will not die of the disease and some may not even need treatment, …
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Pharmacological regulation of c-myc gene expression in human breast cancer cells
… was to understand the molecular mechanisms of c-myc gene regulation by quinidine. C-myc is one of the most common oncogene aberrations in breast cancers (Deming, S. L. et al., 2000). C-myc functions include regulation of cell cycle, proliferation, differentiation, and apoptosis. The results of …
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c-Myc regulates transcriptional pause release and is a global amplifier of transcription
Elevated expression of the c-Myc transcription factor occurs frequently in human cancers and is associated with tumor aggression and poor clinical outcome. However, the predominant mechanism by which c-Myc regulates global transcription in both healthy and tumor cells is poorly understood. In this …
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Novel Cellular Targets of Aspirin in Chemoprevention studies on P53, G6PD and c-MYC
… glucose 6-phosphate dehydrogenase (G6PD), and c-Myc, all of which are known to play a major role in cancer development. p53 is a tumor suppressor protein, often mutated in cancers causing its inactivation. Expression of G6PD is elevated in many cancers, and this significantly contributes to …
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BRIDGING TRANSCRIPTION AND SIGNALING TO STUDY C-MYC FUNCTION AND REGULATION IN CANCER CELLS
The transcription factor c-MYC (MYC) is a master regulator of gene expression and is frequently deregulated in human cancers. Despite the prevalent role of MYC in cancers, no MYC inhibitors are currently available for clinical use. In this work, we investigated the molecular mechanisms underlying …
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Investigations into the role of RNA modification in the function of the c-Myc IRES
… (FBLL1) as binding to the IRES of c-Myc. This protein, largely unstudied, shares homology with Fibrillarin; a well characterised 2’O-methyltransferase ubiquitously expressed and located in the nucleolus, consistent with its role in ribosomal RNA modification and, ribosomal biogenesis. …
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Predictive Computational Modelling of the c-myc Gene Regulatory Network for Combinatorial Treatments of Breast Cancer
… network in breast cancer focused on the c-myc oncogene and the differences between sub-clones. I model the system as a discrete, qualitative network, which can reproduce the conditions in heterogeneous tumours, as well as predict the effect of perturbations mimicking mutations or …
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Discovery and characterization of a small molecule that modulates c-Myc mediated transcription via max homodimer stabilization
The transcription factor Myc is a basic helix-loop-helix leucine zipper (bHLHLZ) protein with crucial roles in regulating normal cellular processes, but its transcriptional activity is deregulated in a majority of human cancers. Myc transcriptional activity is dependent on dimerization with its …
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Local or Systemic Antibody-Targeted Sting Activation Drives Pro- Inflammatory Stromal Metabolic Changes and Downregulates c-MYC Oncoprotein
… by which STING-mediated inhibition of the c-Myc oncogene contributes to the immune repolarization and metabolic reprogramming of tumor myeloid stroma. Additionally, we explore how STING signaling modulates myeloid cell metabolism, inducing a hypometabolic state that may be central to the …
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Gcn5 Impacts Fgf Signaling At Multiple Levels and Activates C-Myc Target Genes During Early Differentiation of Embryoid Bodies
… and most interestingly, 4 of them are c-MYC targets. These findings established a novel link between GCN5 and FGF signaling pathway, and highlighted the GCN5-MYC partnership in gene regulation during early differentiation.</p>
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Identification of proteins interacting with the human mismatch repair protein MLH1
… other genes identified was the proto-oncogene c-MYC, a gene previously implicated in genetic instability and apoptosis. Using in vitro derived mutants of c-MYC, it has been shown that hMLH1 interacts with the leucine-zipper domain of c-MYC. The effect of elevated c-MYC expression on functional …
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Investigating the functional significance of the upregulation of Cyclin D2 and p21 following Apc loss in vivo
… This project focuses on the proto-oncogene c-Myc as it is a key Wnt target gene which is activated following loss of Apc in vivo. This upregulation is noteworthy as c-Myc is implicated in stem cell survival, proliferation, apoptosis and tumourigenesis. Previous studies have shown c-Myc …
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Glucose-6-Phosphatase in Metabolic Disease and Cancer
… show that the oncogenic transcription factor c-Myc potentiates metabolic rewiring and drives lactic acidosis and hyperuricemia in a mouse model of GSD1a. Using metabolic profiling and isotope labeling strategies in both in vivo and cultured cell models of GSD1a, we found enhanced use of both …
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Transcriptional functions of the corepressor Sin3A in skin
… in epidermal stem cells, the proto-oncogene c-Myc triggers their exit from the stem cell compartment resulting in an increase in progenitor cell proliferation and an induction in terminal differentiation. Whether c-Myc plays a direct transcriptional role in epidermal stem cell differentiation …
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Molekulární mechanismy indukce programované buněčné smrti v nádorových buňkách.
… protoonkogenů v nádorových buňkách je C-MYC, což ho předurčuje jako efektivní cíl léčby. Vývoj takovýchto cílených účinných látek je ale velmi nákladný, proto jsou v této práci zkoumány přírodní látky, které byly používány pro léčbu nádorových onemocnění už ve starověké Číně. V této práci …
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