Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"c-Src"”.
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Implication de la c-SRC kinase dans le métabolisme et la morphologie des mitochondries
… ont montré que dans la mitochondrie, la c-Src kinase (tyrosine-kinase) cible des protéines mitochondriales et régule leurs fonctions.
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A Role For Lipid Rafts In Egfr Tki Resistance In Breast Cancer
… shown that the non-receptor tyrosine kinase c-Src, which is co-over-expressed with EGFR in a subset of breast tumors, also localizes to lipid rafts in the SUM159 breast cancer cell line. In this model system, c-Src kinase inhibition results in synergistically decreased cell viability in …
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Hepatitis C Virus-Induced Hepatocellular Carcinoma: Cancer Stem Cell and Gene Therapy
… of a-fetoprotein, cytokeratin-19, c-Myc, and c-Src, and activation of b-catenin pathway in the absence of Wnt ligand. The result presented here implicates a novel cellular internal ribosome entry site (IRES) element in the c-Src mRNA responsible for the overexpression of c-Src proto-oncogene …
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TIS21 inhibits cell migration and invasion
… site was not influenced by TIS21 expression. c-Src phosphorylation which was upstream of FAK was not influenced by TIS21, however, c-Src kinase activity was significantly decreased by TIS21. When we measured Src oxidized state in the cells, TIS21 increased Src reduction state and TIS21 inhibited …
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Targeting Opioid Receptor Signal Transduction to Produce Sustained Analgesia
… neurones for morphine analgesic tolerance; c-Src (a tyrosine kinase), thought to couple to MOP receptors through BAR2 has<br/>also been implicated.<br/><br/>To investigate opioid receptor signalling in response to morphine we used a variety of different techniques that included behavioural …
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Integrinaktivierung und Formation des "fokalen Adhäsionskomplexes" im Hypertrophieprozess adulter Mäuseherzen
… „focal adhesion kinase“(Fak) und c-Src, identifizieren, welche beide zum sogenannten Integrin-abhängigen fokalen Adhäsionskomplex gehören. Weitere Analysen zeigten Phosphorylierungen von Fak bei Tyr-397 und Tyr-925, c-Src bei Tyr-418. Dies lässt darauf schließen, dass beide Kinasen …
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Ταυτοποίηση πρωτεϊνών που αλληλεπιδρούν με τον αυξητικό παράγοντα πλειοτροπίνη και διερεύνηση του λειτουργικού τους ρόλου
… 773 μέσω ενεργοποίησης του RPTPβ/ζ και της c-src. Καθοδικά της ανβ3, η PI3K συμμετέχει σε αυτή τη δράση. Ο VEGF165 που επίσης επάγει το μεμβρανικό εντοπισμό της NCL, δρα μέσω δέσμευσης στον RPTPβ/ζ και ενεργοποίησης του σηματοδοτικού μονοπατιού RPTPβ/ζ/c-src/ανβ3. Η περιοχή δέσμευσης στους …
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Identification of novel biomarkers for clinical prognosis in breast cancer
… factors e.g. c-RAF-1, ERK-1/2, AKT, LYN, SRC family kinases (SFKs) and NFκB (p50 RelA) were analysed in combination with SK1 and S1P receptors to discover novel prognostic interactions that drive cancer progression in ERα positive breast cancer patients. High tumour SK1 expression in …
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Fragmented maternal care programs altered pain vulnerability and aberrant responses to opioids
… receptors (DOP), β-arrestin 2 (Barr2) and c-Src kinase are all components of the opioid signalling system, which to differing degrees have been implicated in pain sensitivity and the behavioural effects of opioids including analgesia, tolerance, hyperalgesia, locomotor function and …
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KGF-1 and KGF receptor expression in human periodontal disease and in vitro microwounding-associated-ligand-independent KGFR activation
… of ROS reduced KGFR phosphorylation. The c-Src family inhibitor, PP1, significantly inhibited KGFR phosphorylation. Functionally cell migration was reduced by PP1 (82.7%), SU5402(70%) and PD98059 (57%). Conclusions: KGF-1 and KGFR proteins are expressed in health but significantly induced in …
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Regulation of STAT-3 and STAT-6 by Transient Oxidative Stress in Rat Brain Astrocytes
… that H2O2 induced rapid STAT-6 activation via c-Src/JAK pathway contributed to the COX-2 dependet PGE2 production in brain astrocytes. I showed that H2O2 induced STAT6 phosphorylation was accompanied by it’s nuclear translocation and DNA binding activity. Experiments using pharmacological …
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"Funcionalidad de los microdominios de membrana en la señalización durante la maduración meiótica de anfibios"
… significativamente con las moléculas señales, c-Src y H-Ras. En estas membranas se encontró una banda proteica que, por espectrometría de masa, se identificó como la cadena pesada de la miosina no muscular planteando la posibilidad de una relación con el citoesqueleto. La depleción de colesterol, …
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Tyrosine Phosphorylation of Villin: Effects on Actin Dynamics, Cell Morphology and Cell Migration
… that tyrosine phosphorylation of villin by c-src is required for villin-induced cell migration. Previously, we identified four tyrosine phosphorylation sites in the amino-terminal domain of villin. I further identified six new sites in the carboxylterminal region of the villin core. …
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A study of keratinocyte differentiation and adhesion in vitro
… an investigation of the role played by the Src-family of protein tyrosine kinases at calcium-induced cadherin-mediated adherens junctions. The ubiquitously expressed members of this family, c-Src, Fyn and c-Yes were localised to the cadherin-mediated adhesions formed in response to high …
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Untersuchungen zur Funktion der Protein-Tyrosin-Phosphatase PTPRR
… der nachgewiesen wurde, ist die Inhibition der c-Src-induzierten Phosphorylierung des KIF1C, welcher am retrograden Transport vom Golgi-Apparat zum Endoplasmatischen Retikulium beteiligt ist. Damit wurde PTPRR als erste PTPase mit einer Dephosphorylierung des KIF1C in Verbindung gebracht. Über in …
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Mechanisms of increased microvascular permeability during acute Rickettsiosis
… kinase activity in the form of protein kinase C, Src, and focal adhesion kinase. Inhibition of Src during R. rickettsii infection led to a decreased rate of endothelial permeability however this did not prevent rickettsiae-mediated cell death. Finally, we have identified several novel pathways …
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Involvement of Histone Deacetylase 4 (HDAC4) in Osteoclast Function
… and migration. Moreover, I demonstrated that c-Src activation in osteoclasts is regulated by HDAC4. The results of this thesis have identified HDAC4 as an essential regulator of osteoclast bone resorption activity both in vivo and in vitro.
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MOLECULAR PHYSIOLOGY OF THROMBOXANE A2 GENERATION IN PLATELETS
… role of three potential tyrosine kinases; c-Src, Syk and FAK (Focal Adhesion Kinase) that are known to be activated by integrins. Our results showed that c-Src and Syk kinase did not play a role in ADP-induced functional responses in platelets. We observed differential activation of FAK …
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