Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"c-REL"”.
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C-Rel Is A Transcriptional Target of Mesoderm Inducer In Xenopus Like 1 (Mixl1)
… putative targets. Of these, the proto-oncogene c-REL was an important target. Both ectopically expressed and endogenous MIXL1 bound <em>REL</em> promoters in myelogenous leukemia cells. Furthermore, cREL was induced under MIXL1 over-expression conditions in the leukemic cell line U937. Targeted …
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Expression des Transkriptionsfaktors NF-kappaB in Zellen des Hodgkin-Lymphoms und des großzelligen anaplastischen Lymphoms
… fand sich zusätzlich konstitutives c-Rel, in den LCAL-Zelllinien dagegen konstitutives RelB. Diese vier Faktoren zeigten auch in den jeweiligen Zellen konstitutive Bindungsaktivität. Die NF-kappaB-Faktoren können als Marker für verschiedene Entwicklungsstufen hämatopoetischer Zellen …
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Roles of NF-kB in spinal cord injury pathophysiology
… Immunohistochemical co-staining with NeuN and c-Rel antibodies demonstrated decreased neuronal c-Rel up to 24 hours after SCI. We also observed significant decreases in the protein levels NF-kB c-Rel up to 12 hours after SCI, signifying its inability to activate genes involved in anti-apoptotic …
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Genetic Subclones Identify Phenotypic Variation in Diffuse Large B-Cell Lymphoma
… A key observation was that amplification of REL (which encodes c-REL, a NF-κB transcription factor subunit), is negatively associated with expression of the memory B cell theme in the discovery dataset (t-test, p = 1×10<sup>−11</sup>) and this was validated in scRNA of genetic subclones …
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Is there a role for NF-κB in the suprachiasmatic circadian clock?
… NF-κB is composed of dimers of members of the Rel family, including p65 (RelA), p50, p52, c-Rel and Rel B. NF-κB transcription factors are required for regulating cell survival and differentiation and also are important for inflammatory and immune responses. Dysregulation of this transcription …
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IL-1 activation of NF-kB contributes to perinatal hypoxia/ischemia induced cell death
… while Bcl-x decoys specifically inhibited c-Rel/p50 (p52) binding activity. RPAs showed that IgG-kB decoys significantly decreased IL-1alpha, TNF-alpha and TNF-beta mRNA levels compared to minimal changes after Bcl-x or scrambled decoy treatment, indicating a specific IgG-kB decoy effect on …
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Repression of Protein Kinase C Delta in Human Squamous Cell Carcinomas by Ras, Fyn and NF-Kappa B Signaling
… in human SCCs, and that the PKC-delta gene is rarely deleted suggesting that the mechanism of down-regulation of PKC-delta in SCCs is likely to be primarily at the level of gene transcription. To further explore the mechanism of PKC-delta down-regulation, we studied Ras-transformed immortalized …
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Transcriptional and Post-transcriptional Control of Nhlh2 with Differing Energy Status
… Stat3 and the NFκB subunits P50, P65, and c-Rel demonstrated that all of these antibodies were able to pull down the part of the Nhlh2 promoter containing the binding sites of Stat3 and NFκB. The EMSA results not only demonstrated that NFκB and Stat3 binding site motifs are real binding …
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Role of NF-κB p65 subunit phosphorylation by ATM in DNA damage-regulated gene expression
… NF-κB. NF-κB family is composed of 5 proteins (RelA/p65, RelB, c-Rel, p105/p50 and p100/p52) which assemble in dimers to form active NF-κB transcription factor. In resting cells, NF-κB complexes are bound to inhibitor proteins such as IκBα, and maintained inactive in the cytoplasm. Classical …