Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 32 for “"c-Met"”.
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Targeting c-Met for therapy
c-Met is a tyrosine receptor kinase which is activated by its only ligand, the hepatocyte growth factor (HGF). Activation of c-Met leads to a wide spectrum of biological activities such as motility, angiogenesis, morphogenesis, cell survival and cell regeneration. c-Met and HGF knock-out mice are …
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Targeting c-met in sonic hedgehog medulloblastomas
… roles in medulloblastoma tumorigenesis. Active c-MET kinase has been detected as a marker of SHH-driven MB and several inhibitors provided pre-clinical evidence for an effective therapy for SHH-MB patients.In this PhD project, we firstly confirmed that c-MET is highly expressed in SHH MBs; next, …
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Matriptase Mediated C-Met Signaling In Breast Cancer
<p>MATRIPTASE MEDIATED c-MET SIGNALING IN CRITICAL FOR BREAST CANCER PROGRESSION </p> <p>by</p> <p>GINA ZORATTI</p> <p> Historically proteases have been associated with tumor progression and metastasis through degradation of the basement membrane. However, in recent years these enzymes have also …
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A mechanism of activation of c-MET receptor tyrosine kinase
c-MET receptor tyrosine kinase-mediated signaling governs numerous important cellular responses including cellular proliferation, differentiation, migration and apoptosis. Deregulation of these signals result in malignant behaviors, often leading to cancers. While the identity of the many signaling …
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Regulation of Hgf Expression By Δegfr-Mediated C-Met Activation In Glioblastoma Cells
… of the hepatocyte growth factor receptor (c-Met) and its ligand, the hepatocyte growth factor (HGF), and a constitutively active mutant of the epidermal growth factor receptor (∆EGFR/EGFRvIII), occur frequently in glioblastoma. c-Met is activated in a ligand-dependent manner by HGF or in a …
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Response to treatment with chemical and biological inhibitors of c-met mutated form
c-MET is a receptor tyrosine kinase that, after binding with its ligand, hepatocyte growth factor (HGF), activates many signaling pathways, driving proliferation, motility, migration and invasion. Although c-MET is important in the control of tissue homeostasis under normal physiological …
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A Novel Function For 12-Lipoxygenase In C-Met And Integrin β4 Axis Crosstalk
<p>Cancer cell metastasis is the single most threatening occurrence of tumor progression and predicts patient prognosis as well as survival. Invasion can be regulated by the Met receptor tyrosine kinase (c-Met), integrin beta4, and the lipid enzyme, 12-Lipoxygenase (12-LOX). Therefore we sought to …
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REGULATION OF C-MET RECEPTOR TYROSINE KINASE SIGNALING BY ANGIOTENSIN-(1-7) IN TRIPLE NEGATIVE BREAST CANCER
Breast cancer remains a devastating disease, negatively impacting the lives of many women worldwide. In the United States, 40,450 women succumbed to breast cancer in 2015, with an estimated 247,000 new cases being diagnosed in 2016. Approximately 15% of all breast cancer cases will be classified as …
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Role of C-Met and Egfr In Acquired Resistance to Parp Inhibitors In Triple-Negative Breast Cancer
… and talazoparib, were recently approved for metastatic breast cancer (including triple-negative breast cancer) in patients with a germline <em>BRCA1/2</em> mutation. Despite impressive response rates of ~60%, the prolongation in median progression-free survival with PARP inhibitors is modest, …
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Up-modulation of Hepatocyte Growth Factor/ c-Met Signaling by Protein Kinase C-g and its Mechanism
… down-modulate the tyrosine kinase activity of c-Met, the receptor for hepaotcyte growth factor (HGF). However, specified roles by PKC isoenzymes on the regulation of HGF/c-Met signaling have never been addressed yet. In this study, attempts have been made to investigate the effect of PKC-γ, an …
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The functional motifs for nucleocytoplasmic shuttling of C-terminal fragment of c-Met : A novel "pH-dependent' nuclear localization signal
The C-terminal fragment of the c-Met receptor tyrosine kinase is present in the nuclei of various cells irrespective of ligand stimulation, but neither the specific amino acid motif nor the responsible nuclear localization signal (NLS) has not been previously reported. Here, we report that two …
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Correlación entre los datos clínico-patológicos y la expresión de los marcadores inmunohistoquímicos c-MET, IGF-1R y VEGFR-2 como factores pronósticos en el adenocarcinoma gástrico
… tumoral. HIPÓTESIS La expresión de c-MET, IGF-1R y VEGFR-2 en el tejido gástrico tumoral puede tener un valor pronóstico de recurrencia en adenocarcinoma gástrico y podría relacionarse con variables clínicas y patológicas. OBJETIVOS Determinar mediante inmunohistoquímica el grado de …
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Development of Rational Combination Therapy With Parp Inhibitors and Kinase Inhibitors In Tnbc
… clinical trials. In this study, we identified c-Met, a tyrosine kinase, phosphorylates PARP1 at Y907 and that the phosphorylation increases PARP1 activity, thereby rendering cancer cells resistant to PARPi. The combination of c-Met inhibitors (METi) and PARPi has a synergistic effect for c-Met …
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Exploring potential inhibitors of the HGF-Met signalling pathway as a prospective treatment for paediatric medulloblastoma
Understanding the function of the HGF-Met signalling axis could present opportunities for new therapeutic treatments for cancer patients. The brain tumour Medulloblastoma is the leading cause of cancer-related death in children and infants meaning research into better treatment of this cancer is …
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The roles of hepatocyte growth factor family members in androgen-regulation of human hair growth. A comparison of the expression of hepatocyte growth factor family members, HGF and MSP, and their receptors, c-Met and RON, in isolated hair follicles from normal and androgenetic alopecia (balding) scalp.
… isolated and analysed by molecular biological methods (reverse transcriptase-polymerase chain reaction (RT-PCR), quantitative PCR and DNA microarray analysis), cell culture and immunohistochemistry. Scalp follicles expressed a range of paracrine messenger genes. The dermal papilla, cultured …
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Quantitative analysis of the EGFRvIII mutant receptor signaling networks in Glioblastoma
… EGFRvIII acts, we have employed a mass spectrometry-based phosphoproteomic approach to quantitatively map cellular signaling events activated by this receptor. Using this approach, we have determined the major downstream pathways activated as a function of titrated EGFRvIII receptor levels. …
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Differential mechanisms by which the aryl hydrocarbon receptor attenuates liver regeneration
… potent mitogenic activity of two proteins, the c-Met transmembrane receptor and urokinase plasminogen activator (uPA). However, this growth response is limited by the expression of plasminogen activator inhibitor-1 (PAI-1) and TGF-?, which terminates hepatocyte proliferation. The goal of these …
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MICRORNAs AS PREDICTIVE AND THERAPEUTIC TOOLS IN PROSTATE CANCER AND BONE METASTASIS
… tra forme indolenti, androgeno insensibili e metastatiche, si rende necessaria per guidare le decisioni terapeutiche e conseguentemente migliorare la prognosi del paziente. in questo studio sono stati valutati gli effetti del recettore c-Met, noto per avere un ruolo significativo nello …
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