Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"c-Maf"”.
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IDENTIFYING, CHARACTERIZING AND VERIFYING NOVEL C-MAF FUNCTIONS IN T CELL DEVELOPMENT AND APOPTOSIS
… is to investigate the mechanisms underlying c-Maf mediated control of developing and mature T cells. c-Maf, a basic leucine zipper transcription factor, is well known for its ability to promote T helper 2 (Th2) differentiation by direct transactivation of IL-4 following interaction with a …
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Understanding T cells in type 1 diabetes: a role for c-Maf and characterization of intracellular signaling following engagement of transgenic Ly49A.
… the mechanisms underlying defective c-Maf binding to the IL-4 promoter in T cells from diabetes prone mice and identify the mechanisms responsible for suppression of T cells by the inhibitory receptor Ly49A. It is not clear why development of protective Th2 cells is poor in T1D. c-Maf …
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Identification and analysis of Il-2 induced Stat5 Target genes in Human CD4 and CD8 T cells
… lineage-specification factors, c-MAF and RORA. Given the importance of IL-2 in<br/>facilitating CD4 Th2 cell differentiation, the regulation of c-MAF by STAT5 was<br/>functionally characterised further using biochemical and molecular techniques. These<br/>studies revealed that the …
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Transcription factor modulation in T-cells to improve cancer immunotherapy
… T-cells, and upregulated expression of AhR and c-MAF, driving heightened production of IL-22, IL-10 and Granzyme B upon tumor encounter. NOTCH1-agonized CD4+ CAR-T demonstrated enhanced antigen responsiveness and proliferated to strikingly higher frequencies in mice bearing human lymphoma …